No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism

Vehviläinen, Mari; Salem, Abdelhakim; Asghar, Muhammad; Salo, Tuula; Siponen, Maria

doi:10.1080/00016357.2020.1720798

Cited by 3 publications

(7 citation statements)

References 28 publications

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“…A basic overview of parameters of these eligible publications is discussed here. Study characteristics of the 14 studies [18][19][20][21][22][23][24][25][26][27][28][29][30][31], including the type of study, population, intervention, control, outcomes (PICO), biomarkers, assay methodology, and specimen types, are presented in Table 1. The final 14 studies were then eligible for inclusion in this scoping review.…”

Section: Overview Of Search Resultsmentioning

confidence: 99%

“…It is hypothesized that thyroid disease could result in the development of OLP. This is attributed to the similar molecular mimicry seen in both hypothyroidism and OLP, where there could be similar antigens and human autoantigens involved [30]. Vehviläinen et al [30] reported that there were studies on antithyroid antibodies contributing to the initiation of an autoimmune response in the oral cavity.…”

Section: Discussionmentioning

confidence: 99%

Section: Tsh and Antithyroid Antibody Expression In Olp Patientsmentioning

confidence: 99%

“…Two studies [28,30] looked at the expression of thyroid-stimulating hormone (TSH) and antithyroid antibodies in oral lichen planus (OLP) patients. Vehviläinen et al [30] obtained negative results from both qRT-PCR and ddPCR for TSH from OLP lesions from both patients with hypothyroidism and without. However, Robledo-Sierra et al [28] found that more patients in the OLP+/LT4+ group had low levels of FT3 (p = 0.0.387), while more patients from the OLP-/LT4+ group had high levels of FT4 (p = 0.142).…”

Section: Tsh and Antithyroid Antibody Expression In Olp Patientsmentioning

confidence: 99%

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The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review

Yang

et al. 2022

IJMS

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The hypothalamic–pituitary–thyroid (HPT) axis is crucial in regulating thyroid hormone levels that contribute to the development and homeostasis of the human body. Current literature supports the presence of a local HPT axis equivalent within keratinocytes of the skin, with thyroid hormones playing a potential role in cancer progression. However, this remains to be seen within oral tissue cells. An electronic search of Scopus and PubMed/Medline databases was conducted to identify all original publications that reported data on the production or effects of HPT axis components in normal or malignant cells of the oral cavity. The search identified 221 studies, of which 14 were eligible. Eight studies were retrospective analyses of clinical samples, one study involved both in vivo and in vitro experiments, and the remaining five studies were conducted in vitro using cell lines. The search identified evidence of effects of HPT components on oral cancer cells. However, there were limited data for the production of HPT axis components by oral tissues. We conclude that a possible role of the local HPT axis equivalent in the oral mucosa may not be established at present. The gaps in knowledge identified in this scoping review, particularly regarding the production of HPT components by oral tissues, warrant further investigation.

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Section: Overview Of Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tsh and Antithyroid Antibody Expression In Olp Patientsmentioning

confidence: 99%

Section: Tsh and Antithyroid Antibody Expression In Olp Patientsmentioning

confidence: 99%

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The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review

Yang

et al. 2022

IJMS

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“…The study included 38 patients out of whom 14 had OLP and HT, 14 had only OLP, and 10 were healthy controls. However, both stains were found negative [102], and a larger exploration of this potential link is mandatory.…”

Section: Connecting the Dots Between Lp/olp And Thyroid Anomalies 421...mentioning

confidence: 94%

Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies

Radu,

Carsote,

Nistor

et al. 2023

Biomedicines

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In this narrative review, we aimed to overview the interplay between lichen planus (LP) and thyroid conditions (TCs) from a dual perspective (dermatologic and endocrine), since a current gap in understanding LP-TC connections is found so far and the topic is still a matter of debate. We searched PubMed from Inception to October 2023 by using the key terms “lichen planus” and “thyroid”, (alternatively, “endocrine” or “hormone”). We included original clinical studies in humans according to three sections: LP and TC in terms of dysfunction, autoimmunity, and neoplasia. Six studies confirmed an association between the thyroid dysfunction (exclusively hypothyroidism) and LP/OL (oral LP); of note, only one study addressed cutaneous LP. The sample size of LP/OLP groups varied from 12–14 to 1500 individuals. Hypothyroidism prevalence in OLP was of 30–50%. A higher rate of levothyroxine replacement was identified among OLP patients, at 10% versus 2.5% in controls. The highest OR (odd ratio) of treated hypothyroidism amid OLP was of 2.99 (p < 0.005). Hypothyroidism was confirmed to be associated with a milder OLP phenotype in two studies. A single cohort revealed a similar prevalence of hypothyroidism in LP versus non-LP. Non-confirmatory studies (only on OLP, not cutaneous LP) included five cohorts: a similar prevalence of hypothyroidism among OLP versus controls, and a single cohort showed that the subjects with OLP actually had a lower prevalence of hypothyroidism versus controls (1% versus 4%). Positive autoimmunity in LP/OLP was confirmed in eight studies; the size of the cohorts varied, for instance, with 619 persons with LP and with 76, 92, 105, 108, 192, 247, and 585 patients (a total of 1405) with OLP, respectively; notably, the largest control group was of 10,441 individuals. Four clusters of approaches with respect to the autoimmunity in LP/OLP were found: an analysis of HT/ATD (Hashimoto’s thyroiditis/autoimmune thyroid diseases) prevalence; considerations over the specific antibody levels; sex-related features since females are more prone to autoimmunity; and associations (if any) with the clinical aspects of LP/OLP. HT prevalence in OLP versus controls was statistically significantly higher, as follows: 19% versus 5%; 12% versus 6%; and 20% versus 9.8%. A single study addressing LP found a 12% rate of ATDs. One study did not confirm a correlation between OLP-associated clinical elements (and OLP severity) and antibody values against the thyroid, and another showed that positive TPOAb (anti-thyroperoxidase antibodies) was more often found in erosive than non-erosive OLP (68% versus 33%). Just the reverse, one cohort found that OLP subjects had a statistically significantly lower rate of positive TPOAb versus controls (9% versus 15%). Five case-control studies addressed the issue of levothyroxine replacement for prior hypothyroidism in patients that were diagnosed with OLP (no study on LP was identified); three of them confirmed a higher rate of this treatment in OLP (at 8.9%, 9.7%, and 10.6%) versus controls. In conclusion, with regard to LP/OLP-TC, we note several main aspects as practical points for multidisciplinary practitioners: OLP rather than LP requires thyroid awareness; when it comes to the type of thyroid dysfunction, mostly, hypothyroidism should be expected; female patients are more prone to be associated with ATDs; a potential higher ratio of OLP subjects taking levothyroxine was found, thus a good collaboration with an endocrinology team is mandatory; and so far, OLP individuals have not been confirmed to be associated with a higher risk of thyroid nodules/cancer.

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Oral lichen planus and systemic diseases: casual association or causal?

Porto,

Figueiredo,

Dos Anjos

et al. 2023

CLIUM

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Lichen planus (LP) is a chronic inflammatory disease, mediated by T cells, with a multifactorial etiology, being associated with various diseases and systemic conditions. The objectives of this study are to determine, through the analysis of the literature, the casuistic or causal relationship in the concomitant presentation of Oral Lichen Planus (OLP) and other systemic diseases, and to analyze a series of cases treated at the University Hospital of Brasília (HUB) between 2015 and 2020. Methodology: This study was developed through a review of the literature published between 2016 and 2022, relating systemic diseases with OLP and the analysis of series of OLP cases treated at the HUB. Results: The review showed evidence of the relationship between OLP and Thyroid Disease (TD), Psychiatric Disease (PD), HPV virus and oxidative stress. Furthermore, it was observed that alterations in the oral bacterial microbiota are associated with the progression of OLP. Analysis of the case series identified a relationship between TD and PD with OLP. Conclusion: It is observed that there is strong evidence of the relationship between OLP and DT, DP, HPV virus, oxidative stress and the presence of periodontal bacteria in the oral cavity.

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No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism

Cited by 3 publications

References 28 publications

The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review

The Hypothalamic–Pituitary–Thyroid Axis Equivalent in Normal and Cancerous Oral Tissues: A Scoping Review

Crossroads between Skin and Endocrine Glands: The Interplay of Lichen Planus with Thyroid Anomalies

Oral lichen planus and systemic diseases: casual association or causal?

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