No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis

Muratore, Francesco; Croci, Stefania; Tamagnini, Ione; Zerbini, Alessandro; Bellafiore, Salvatore; Belloni, Lucia; Boiardi, Luigi; Bisagni, Alessandra; Pipitone, Nicolò; Parmeggiani, Maria; Cavazza, Alberto; Salvarani, Carlo

doi:10.1016/j.semarthrit.2017.02.005

Cited by 36 publications

(17 citation statements)

References 28 publications

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“… 3 – 5 , 15 However, with the exception of Mitchell and Font, 16 other investigators have not found substantial VZV in the arterial specimens of biopsy-proven GCA or clinically diagnosed GCA. 17 – 22 False positive immunohistochemistry from antibody cross-reactivity to shared epitopes between VZV proteins and arterial smooth muscle elements suggest caution when interpreting pathology findings. 23 Gilden and Nagel acknowledge that “the presence of VZV in about 20% of temporal artery biopsies from non-GCA post-mortem controls also suggests that VZV alone is not sufficient to produce disease”.…”

Section: Discussionmentioning

confidence: 99%

Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Ing

Ing²,

Liu

et al. 2018

OPTH

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PurposeGiant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by vaccination, has been proposed as a possible immune trigger for GCA, but this is controversial. The incidence of GCA varies widely by country. If VZ virus contributes to the immunopathogenesis of GCA we hypothesized that nations with increased incidence of GCA would also have increased incidence of herpes zoster (HZ). We conducted an ecologic analysis to determine the relationship between the incidence of HZ and GCA in different countries.MethodsA literature search for the incidence rates (IRs) of GCA and HZ from different countries was conducted. Correlation and linear regression was performed comparing the disease IR of each country for subjects 50 years of age or older.ResultsWe found the IR for GCA and HZ from 14 countries. Comparing the IRs for GCA and HZ in 50-year-olds, the Pearson product-moment correlation (r) was −0.51, with linear regression coefficient (β) −2.92 (95% CI −5.41, −0.43; p=0.025) using robust standard errors. Comparing the IRs for GCA and HZ in 70-year-olds, r was −0.40, with β −1.78, which was not statistically significant (95% CI −4.10, 0.53; p=0.12).ConclusionAlthough this geo-epidemiologic study has potential for aggregation and selection biases, there was no positive biologic gradient between the incidence of clinically evident HZ and GCA.

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Section: Discussionmentioning

confidence: 99%

Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Ing

Ing²,

Liu

et al. 2018

OPTH

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“…Activation of these cells by pathogen‐associated molecular patterns or damage‐associated molecular patterns, including ligands for Toll‐like receptors, may trigger the initial inflammatory response, resulting in chemokine‐mediated migration of immune cells via the vasa vasorum . Although it has been suggested that varicella zoster virus might be directly involved in the development of GCA , a growing number of studies strongly dispute this notion . DCs stimulate T cells with their cognate peptides bound to class II major histocompatibility molecules, costimulatory molecules (i.e., CD80/CD86), and cytokines.…”

Section: Evidence For Distinct Gca Subsets Based On Immunologic Featuresmentioning

confidence: 99%

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Geest

Sandovici

Sleen

et al. 2018

Arthritis & Rheumatology

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Giant cell arteritis (GCA) is an autoimmune vasculitis affecting large and medium‐sized arteries. Ample evidence indicates that GCA is a heterogeneous disease in terms of symptoms, immune pathology, and response to treatment. In the current review, we discuss the evidence for disease subsets in GCA. We describe clinical and immunologic characteristics that may impact the risk of cranial ischemic symptoms, relapse rates, and long‐term glucocorticoid requirements in patients with GCA. In addition, we discuss both proven and putative immunologic targets for therapy in patients with GCA who have an unfavorable prognosis. Finally, we provide recommendations for further research on disease subsets in GCA.

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“…Arch Rheumatol 2018;33(4):494-495. support the hypothesis of the GCA development after VZV reactivation. 4,5 Contrary to these studies, VZV antigen was detected in temporal arteries of patients with GCA in a study. 6 Another study reported that VZV is a risk factor for the development of GCA.…”

Section: Citationmentioning

confidence: 63%

Polymyalgia Rheumatica After Herpes Zoster

et al. 2018

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No detection of varicella-zoster virus in temporal arteries of patients with giant cell arteritis

Cited by 36 publications

References 28 publications

Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

Polymyalgia Rheumatica After Herpes Zoster

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