No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women

Abstract

Background: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women. Methods: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure were measured. Body mass index (BMI) was calculated. Fat mass and visceral adipose tissue mass were assessed using dual X-ray absorptiometry scan. Fasting glucose, insulin, lipid profile, high sensitivity C-reactive protein (hs-CRP) and lactoferrin levels were determined. Results: Lactoferrin levels did not differ between MHO and MUHO subjects (median (interquartile range): 1639 (1055–2396) vs. 1622 (1009–23345) ng/mL). However, in the total population insulin (r = 0.131, p = 0.0234) and hs-CRP (r = 0.165, p = 0.0045) levels were correlated with lactoferrin concentrations. In addition, a weak positive association between serum lactoferrin concentrations and anthropometric parameters was also detected, and predominantly referred to MHO group (body weight: r = 0.231, p = 0.0201; BMI: r = 0.286, p = 0.0037; waist circumference: r = 0.258, p = 0.0092). In addition, serum lactoferrin concentrations were negatively correlated with fasting glucose (r = −0.250, p = 0.0115) and HDL-C levels (r = −0.203, p = 0.0411) in MHO subjects. Conclusions: Lactoferrin levels did not differ between MHO and MUHO women. However, some mild correlations between lactoferrin concentrations and anthropometric and metabolic parameters were observed mostly in MHO subjects.

Bioinformatic methods for stratification of obese patients and identification of cancer susceptibility biomarkers based on the analysis of the gut microbiome

“…Individuals in the MU and MH groups had significant differences in their anthropometric parameters. These differences are due to the MU/MH classification criteria, which introduces a bias so that MU patients have increased metabolic indicators in general, and are consistent with the findings of previous studies [22,76,77]. We also found the MHNO individuals to be younger than their unhealthy pairs, consistently with the fact that the prevalence of metabolic disease increases with age [78].…”

Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study

“…We found similar hsCRP levels between MHO and MUO group, which differed significantly to MHNO, and the association of numbers of MetS components with serum hsCRP began no more significant in the model additionally adjusted for obesity indicators. Studies conducted in Mitchelstown cohort participants, 43 Wielkopolska general population 44 and a large sample of Brazilian population 23 all reported a similar level of CRP between MHO and MUO group. A study using six sets of criteria to define MHO found no significant difference of CRP with MUO subjects after multivariate analysis.…”

Associations of Obesity-metabolic Status With Insulin Resistance and Chronic Inflammation Level: Results From the CNTR Study

“…We found similar hsCRP levels between MHO and MUO group, which differed signi cantly to MHNO, and the association of numbers of MetS components with serum hsCRP began no more signi cant in the model additionally adjusted for obesity indicators. Studies conducted in Mitchelstown cohort participants (41), Wielkopolska general population (42) and a large sample of Brazilian population (22) all reported a similar level of CRP between MHO and MUO group. A study using six sets of criteria to de ne MHO found no signi cant difference of CRP with MUO subjects after multivariate analysis (43).…”