No Difference of Serum Il-6 Level Among Dipper and Non Dipper Hypertensive Patients

Ayukusuma, Anggita Rahma; Rohman, Muhammad Saifur; Lukitasari, Mifetika; Supono, Supono; Yunita, Lowry; Setyasari, Arinta; Karolina, Wella; Valerina, Y. S. P.; Madjidi, Arina; Kurniawan, Aditya; Widodo, Nashi

doi:10.1097/01.hjh.0000469858.46811.f4

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“…Performed on forty-eight hypertensive patients, study concluded that IL-6 serum level did not differ among dipper and nondipper hypertensive patients. [41] Diabetes mellitus and metabolic syndrome Decline of physiological mechanisms in hypertensive patients with diabetes mellitus or metabolic syndrome (MS), are considered to be also responsible for the non-dipper hypertension pattern: insulin resistance (anti-diuretic action of insulin), exaggerated response to internal vasoconstrictors, surge of SNS activity, damage endothelium-vasodilatation dependant and results of thickening in vascular smooth muscle. [10] Duggal and colab.…”

Section: Autonomic Nervous Systemmentioning

confidence: 99%

Clinical Conditions and Predictive Markers of Non-Dipper Profile in Hypertensive Patients

Ţilea

Petra

Ardeleanu

et al. 2018

Acta Medica Marisiensis

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Hypertension remains one of the primary causes of premature cardiovascular mortality representing a major independent risk factor.The importance of ambulatory blood pressure monitoring in clinical evaluation of hypertensive patients, beyond diagnosis, is the identification of circadian dipping/non-dipping profile. The non-dipper pattern in hypertensive and normotensive patients is associated with significant target organ damage and worse outcomes, as an increased cardiovascular risk condition. Non-dipping pattern has been found to be associated with specific clinical conditions. Obesity, diabetes mellitus, metabolic syndrome, obstructive sleep apnea syndrome, chronic kidney disease, autonomic and baroreflex dysfunctions, salt sensitivity, hormonal changes, gender and age were extensively studied. Research efforts are focused on recognizing and exploring predictive markers of abnormal blood pressure circadian pattern. Previous studies acknowledge that red cell distribution width, mean platelet volume, fibrinogen level, C-reactive protein, serum uric acid and gamma-glutamyltransferase, are independently significant and positive associated to non-dipping pattern. Moreover, research on new biomarkers are conducted: Chitinase 3-Like-Protein 1, atrial and B-type natriuretic peptide, brain-derived neurotrophic factor, chemerin, sphingomyelin and the G972R polymorphism of the insulin receptor substrate-1 gene. This review summarizes the current knowledge of different clinical conditions and biomarkers associated with the non-dipper profile in hypertensive patients.

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Section: Autonomic Nervous Systemmentioning

confidence: 99%