No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris

Parys, Anthea Van; Lysne, Vegard; Øyen, Jannike; Dierkes, Jutta; Nygård, Ottar

doi:10.1016/j.hnm.2020.200112

Cited by 2 publications

(1 citation statement)

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“…In addition, the number of studies focusing on TMAO and CVD is increasing, but it remains unclear whether TMAO is a causative factor or a biomarker for CVD ( 64 ). In an earlier study, we found that TMAO did not mediate the association between dietary choline intake and risk of acute myocardial infarction in patients with stable angina pectoris ( 65 ). Furthermore, a recent review by Thomas and Fernandez ( 66 ) investigating the role of diet and TMAO in CVD concluded that further evaluation of how TMAO precursors influence CVD and plasma TMAO concentrations is needed.…”

Section: Discussionmentioning

confidence: 85%

Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study

Parys

Brække

Karlsson

et al. 2022

The Journal of Nutrition

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Background Choline is an essential nutrient for humans and is involved in various physiological functions. Through its metabolite betaine, it is closely connected to the one-carbon metabolism and the fat-soluble choline form phosphatidylcholine is essential for very-low-density-lipoprotein synthesis and secretion in the liver connecting choline to the lipid metabolism. Dietary recommendations for choline are not available in the Nordic countries primarily due to data scarcity. Objective The aim of this study was to investigate the dietary intake of total choline and individual choline forms, dietary sources, and the association of total choline intake with circulating one-carbon metabolites and lipids. Methods We included 5746 participants in the Hordaland Health Study (HUSK), a survey including community-dwelling adults born in 1925–1927 (mean age 72 years, 55% women) and 1950–1951 (mean age 48 years, 57% women). Dietary data was obtained using a 169-item food frequency questionnaire and choline content was calculated using the USDA Database for Choline Content of Common Foods, release 2. Metabolites of the one-carbon and lipid metabolism were measured in a non-fasting blood sample obtained at baseline and association with total choline intake were assessed using polynomial splines. Results The geometric mean (95% prediction interval) energy-adjusted total choline intake was 260 (170, 389) mg/d with phosphatidylcholine being the main form (44%). The major food items providing dietary choline were eggs, low-fat milk, potatoes, and leafy vegetables. Dietary total choline was inversely associated with circulating concentrations of total homocysteine, glycine and serine and positively associated with choline, methionine, cystathionine, cysteine, trimethyllysine, trimethylamine-N-oxide and dimethylglycine. A weak association was observed between choline intake and serum lipids. Conclusion Phosphatidylcholine was the most consumed choline form in community-dwelling adults in Norway. Our findings suggest that choline intake is associated with the concentration of most metabolites involved in the one-carbon and lipid metabolism.

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Section: Discussionmentioning

confidence: 85%

Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study

Parys

Brække

Karlsson

et al. 2022

The Journal of Nutrition

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Microbiome Medicine: Microbiota in Development and Management of Cardiovascular Diseases

Garg

Kanwar

Dodiya

et al. 2022

EMIDDT

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The gut microbiome consists of the trillions of bacteria and other microbes whose metabolic activities and interactions with the immune system go beyond the gut itself. We are all aware that bacteria and other microorganisms have a significant impact on our health. Also, health of the bacteria directly reflects the health status of the body where they reside. Eventually, alterations in the microbiome at different sites of a body is associated with many different diseases such as obesity, IBD, malnutrition, CVD, etc. Microbiota directly or indirectly affects the heart with formation of plaques in the blood vessels and cell wall become prone to the lesion development. This ultimately leads to heighten the overall inflammatory status via increased bacterial translocation. Metabolites derived from the gut microbial metabolism of choline, phosphatidylcholine, and L-carnitine directly contribute to CVD pathology. These dietary nutrients have trimethylamine (TMA) moiety, which participates in the development of atherosclerotic heart disease. The objective of this review was to examine various metabolic pathways regulated by the gut microbiome that appear to alter heart function and lead to the development and progression of cardiovascular diseases, as well as how to target the gut microbiome for a healthier heart. In this review, we had also discussed about various clinical drugs having crosstalk between microbiota and heart and clinical trials for gut-heart microbiome.

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No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris

Cited by 2 publications

References 8 publications

Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study

Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health Study

Microbiome Medicine: Microbiota in Development and Management of Cardiovascular Diseases

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