No Effects of Anti-Motion Sickness Drugs on Vestibular Evoked Myogenic Potentials Outcome Parameters

Vanspauwen, Robby; Weerts, A.; Hendrickx, Marilyn; Buytaert, K.I.; Blaivie, CathÃ©rine; Heyning, Paul Van de; Wuyts, Floris L.

doi:10.1097/mao.0b013e31820d94d0

Cited by 11 publications

(6 citation statements)

References 61 publications

(22 reference statements)

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“…This is perhaps not surprising given the ability to right per se is not dependent on the SC, only the ability to modulate righting by height is. Rather the vestibular system is responsible for overall righting [39] and there is evidence that amphetamine does not impact on this system [56]. In addition, there was no alteration to the plane in which righting occurred.…”

Section: Discussionmentioning

confidence: 97%

Chronic amphetamine treatment affects collicular-dependent behaviour

Turner

Stramek

Kraev

et al. 2018

Behavioural Brain Research

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Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. However, when amphetamine is used to treat distractibility, it is given chronically, yet no data exist on whether chronic amphetamine treatment affects the colliculus. Here, the effect of chronic amphetamine treatment was assessed in healthy hooded lister rats on two collicular dependent behaviours following a twenty-eight day treatment period: i) orienting to visual stimuli, and ii) height-dependent modulation of air-righting. We found no significant impact of amphetamine treatment on visual orienting despite showing dose-dependent decreases in orienting to repeated stimuli. However, we did find that treatment with amphetamine significantly reduced the ability to modulate righting according to the height the animal is dropped from - a function known to be dependent on the colliculus. We suggest that the results are in line with previous research showing acute amphetamine suppresses collicular activity and we speculate that the psychostimulant may increase receptive field size, altering time-to-impact calculations carried out by the colliculus during air-righting.

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Section: Discussionmentioning

confidence: 97%

Chronic amphetamine treatment affects collicular-dependent behaviour

Turner

Stramek

Kraev

et al. 2018

Behavioural Brain Research

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“…Additionally, we evaluated saccular function by performing c-VEMP testing. Details on the procedure have been published previously (Colebatch et al, 1994; Vanspauwen et al, 2011). In brief, a patient’s saccular function is quantified by the response of the ipsilateral sternocleidomastoid muscle to air-conducted 500 Hz tone bursts delivered monoaurally via insert phones.…”

Section: Methodsmentioning

confidence: 99%

Cognitive Function in Acquired Bilateral Vestibulopathy: A Cross-Sectional Study on Cognition, Hearing, and Vestibular Loss

et al. 2019

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Background Several studies have demonstrated cognitive deficits in patients with bilateral vestibulopathy (BVP). So far, little attention has been paid to the hearing status of vestibular patients when evaluating their cognition. Given the well-established link between sensorineural hearing loss (SNHL) and cognitive decline and the high prevalence of SNHL in BVP patients, it is therefore uncertain if the cognitive deficits in BVP patients are solely due to their vestibular loss or might be, partially, explained by a concomitant SNHL. Objective To evaluate the link between cognition, hearing, and vestibular loss in BVP patients. Design Prospective cross-sectional analysis of cognitive performance in patients with BVP and control participants without vestibular loss. Both groups included subjects with a variety of hearing (dys)function. Cognition was assessed by means of the Repeatable Battery for the Assessment of Neuropsychological Status for Hearing Impaired Individuals (RBANS-H). Results Sixty-four BVP patients were evaluated and compared with 83 control participants. For each subscale and the totale RBANS-H scale a multiple linear regression model was fitted with the following variables: vestibular loss, hearing loss, age, gender, and education. Hearing loss seemed to be associated with worse outcome on the total RBANS-H scale and subscales immediate memory and language. Vestibular loss, on the other hand, was linked to worse performance on the attention subscale of the RBANS-H. Furthermore, we did not observe a correlation between saccular function and cognition. Conclusion This study has found general cognitive deficits in a large sample size of BVP patients. Multiple linear regression models revealed that both vestibular and hearing dysfunction were associated with different subscales of the cognitive test battery, the RBANS-H. Whereas hearing loss was associated with worse performance on total RBANS-H score, immediate memory and language, vestibular loss was observed to negatively affect attention performance.

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“…Additionally, saccular function was evaluated by performing c-VEMP testing. Details on the procedure have been published previously [18,19]. In brief, a patient's saccular function was quantified by the response of the ipsilateral sternocleidomastoid muscle to air-conducted 500 Hz tone bursts delivered monoaurally via insert phones.…”

Section: Vestibular Testingmentioning

confidence: 99%