No effects of MRI scan on male reproduction hormones

Abstract

This is an accepted version of a paper published in Reproductive Toxicology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination.Citation for the published paper: Møllerløkken, O., Moen, B., Baste, V., Magerøy, N., Oftedal, G. et al. (2012) "No effects of MRI scan on male reproduction hormones." Reproductive Toxicology URL: http://dx.doi.org/10. 1016/j.reprotox.2012.04.003 Access to the published version may require subscription. A prospective randomized balanced cross-over study using a head scan in real MRI with whole-body transmitting coil and sham MRI among 24 healthy male volunteers was conducted. Serum-blood samples of inhibin B, testosterone, prolactine, thyreotropine, luteinizing hormone, follicle stimulating hormone, sex-hormone binding globuline and estradiol were taken before and after the different scans. Neither immediately after, nor after 11 days were there seen any differences in the hormone levels comparing real and sham MRI. The lack of effects of EMF on male reproductive hormones should be reassuring to the public and especially for men examined in MRI. Adverse effects on other endpoints than male reproduction or possible chronic effect of multiple MRI scans have not been investigated in this study. Abstract (150 words)The use of mMagnetic resonance imaging (MRI) is increasing around the world and the possible adverse effects on reproductive health of electromagnetic fields (EMF) in MRI are not previously studied. We conducted aA prospective randomized balanced cross-over study using a head scan in real MRI with whole-body transmitting coil and sham MRI scan among 24 healthy male volunteers was conducted. Serum-blood samples of inhibin B, testosterone, prolactine, thyreotropine, luteinizing hormone, follicle stimulating hormone, sex-hormone binding globuline and estradiol were taken before and after the different scans. Neither immediately after, nor after 11 days were there seen any differences in the hormone levels comparing real and sham MRI. The lack of effects of EMF on male reproductive hormones should be reassuring to the public and especially for men examined in MRI. Adverse effects on other endpoints than male reproduction or possible chronic effect of multiple MRI scans have not been investigated in this study. Your reviewers have given us valuable comments which my coauthors and I hope to have addressed properly in this letter and in the revised manuscript. We have described our response in the letter and given reference to where in the revised manuscript the changes are. We have also highlighted the changed text in the revised manuscript.We hope you will consider this revised manuscript. Do not hesitate to contact me if anything is unclear. Thank you. Yours sincerelyOle Jacob Møllerløkken Institute of Public Health and Primary Health CareUniversity of Bergen Bergen -Norway *Response to Reviewer CommentsReviewer #1:This is an interesting manuscript with relevance to human patients. The authors conducted a randomized...

Occupational exposure to electromagnetic fields in magnetic resonance environment: an update on regulation, exposure assessment techniques, health risk evaluation, and surveillance

“…The effects on male reproductive hormones were investigated in 24 healthy, male volunteers exposed to 1.5 T MRI. No differences were observed in the serum blood level of a series of key hormones neither immediately after, nor after 11 days of MRI and sham exposure [103].…”

The Influence of Vitamin E and Omega-3 Fatty Acids on Reproductive Health Indices Among Male Workers Exposed to Electromagnetic Fields

“…As it was stated earlier, the numerous studies conducted on humans and animals regarding the effects of EMFs on reproductive indices have controversial and contradictory reports ( Wang et al, 2016 ). Certain studies on humans report that exposure to EMFs does not cause any changes to male reproductive indices ( Hjollund et al, 1998 ; Møllerløkken et al, 2012 ). Many animal studies report that exposure to EMFs can cause reductions in reproductive indices such as testosterone ( Kesari & Behari, 2012 ; Sepehrimanesh et al, 2014 ; Shahin et al, 2014 ) but can in some cases increase testosterone ( Forgács et al, 2004 ).…”

Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers

“…20 The results of human and animal studies have differed on the effects of EMF radiation on reproductive hormones. 21 While a number of human and animal studies have reported no change in male reproductive hormones at exposure to EMF, 11,[22][23][24][25][26][27][28][29][30] others have claimed that exposure to EMF can decrease testosterone levels. 18,20,[31][32][33][34][35] Even in some cases, increases in testosterone, LH, and FSH have been reported.…”