No effects of probiotics on atopic dermatitis in infancy: a randomized placebo‐controlled trial

Abstract

We found no clinical or immunological effect of the probiotic bacteria used in infants with AD. Our results indicate that oral supplementation with these probiotic bacterial strains will not have a significant impact on the symptoms of infantile AD.

Probiotics and immunity

“…133 Cytokine production by PBMCs in response to polyclonal stimuli was not affected in participants of trials where probiotic supplementation did not show a significant effect. 134,135 In contrast, improvements in SCORAD scores were associated with increased IFN-γ production in studies where probiotic supplementation was beneficial at least in certain subgroups of patients. 136,137 In addition, the induction of low-grade infl ammation, as indicated by increased serum CRP and IL-6 levels, has been proposed as a mechanism.…”

Microbiota and Allergy: From Dysbiosis to Probiotics

“…Moreover, the heat-inactivated LGG used in Kirjavainen's study induced adverse gastrointestinal symptoms and diarrhea leading to the recruitment of patients being stopped after the pilot phase (Kirjavainen et al, 2003). Six other studies, similar in terms of subjects included and protocol, did not find any improvement in SCORAD scores following LGG supplementation (Folster-Holst et al, 2006;Brouwer et al, 2006;Gruber et al, 2007;Viljanen et al, 2005b;Nermes et al, 2011;Rose et al, 2010). Other probiotic strains have been studied, and Bifidobacterium lactis Bb12 (Isolauri et al, 2000), L. sakei KCTC 10755B0 and L. fermentum VRI-003 (Weston et al, 2005) induced significant decreases in SCORAD scores.…”

“…In the last of these studies, the effects of L. fermentum VRI-003 were found to persist two months after the end of supplementation. Four studies used a L. rhamnosus strain (not LGG) alone (Brouwer et al, 2006) or mixed with L. reuteri (Rosenfeldt et al, 2003) or with other Lactobacillus sp. and Bifidobacterium sp.…”

“…The age range of subjects included varies between studies: around weaning (median 5 months old) (Brouwer et al, 2006;Isolauri et al, 2000;Kirjavainen et al, 2003;Viljanen et al, 2005b;Gruber et al, 2007), around 1 year old (Weston et al, 2005;Folster-Holst et al, 2006), and around 5 years old (Rosenfeldt et al, 2003(Rosenfeldt et al, , 2004Sistek et al, 2006;Woo et al, 2010). Seven of these publications describe effects of Lactobacillus rhamnosus GG LGG in infants but report contradictory results (Brouwer et al, 2006;Isolauri et al, 2000;Kirjavainen et al, 2003;Viljanen et al, 2005b;Gruber et al, 2007;Folster-Holst et al, 2006;Nermes et al, 2011). Two of them (Isolauri et al, 2000;Kirjavainen et al, 2003) showed a significant decrease of the SCORAD score, but both these studies included only small groups of infants (27 and 35).…”

Trends in dairy and non-dairy probiotic products - a review

“…However, these studies did attract criticisms regarding their favored design towards desired outcome and interpretation of the data (Matricardi 2002). In addition to this, some studies demonstrated that the probiotic supplementation has no significant impact on the symptoms associated with infantile AD (Brouwer et al 2006) and hence, increased the risk of allergen sensitization in children with a high-risk of atopic diseases (Taylor et al 2007). It could be potentially unsafe in people sensitive to cow's milk allergy (Moneret-Vautrin et al 2006;Lee et al 2007).…”