No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach

Schumacher, Johannes; Otte, Andreas Cyrill Joachim; Becker, Tim; Sun, Yi; Wienker, Thomas F.; Wirth, Brunhilde; Franke, Petra; Jamra, Rami Abou; Propping, Peter; Deckert, Jürgen; Nöthen, Markus M.; Cichon, Sven

doi:10.1007/s00439-003-1022-5

Cited by 16 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, subsequent studies have not conWrmed this Wnding [31,32]. What is certain is that in clinical practice, the association between both phenomena is clear.…”

Section: Psychopathological Factors Associated With Jhsmentioning

confidence: 83%

Joint hypermobility syndrome: problems that require psychological intervention

et al. 2011

View full text Add to dashboard Cite

Joint hypermobility syndrome (JHS), also known as Ehlers-Danlos III, is an inherited disorder of connective tissue, characterised by an exceptional increase in the joint's mobility and the presence of musculoskeletal and other symptoms. It is a benign syndrome if compared with the other types of Ehlers-Danlos, but it can become disabling particularly because it is a significant source of pain and distress. The purpose of this work is to describe some common problems in JHS that render psychological intervention in their overall management relevant. Chronic pain, associated psychopathological factors such as anxiety, depression and somatosensory amplification, and problems arising from a lack of recognition and knowledge of the syndrome, are frequent among those affected, having a negative impact on their quality of life. We emphasise the relevance of addressing JHS from a biopsychosocial approach.

show abstract

“…However, subsequent studies have not conWrmed this Wnding [31,32]. What is certain is that in clinical practice, the association between both phenomena is clear.…”

Section: Psychopathological Factors Associated With Jhsmentioning

confidence: 83%

Joint hypermobility syndrome: problems that require psychological intervention

et al. 2011

View full text Add to dashboard Cite

show abstract

“…This hypothesis of a single genetic locus segregating with both gJHM and selected psychopathologic traits was initially suggested by the identification of an interstitial duplication in 15q24–26 (named “DUP15”) significantly associated with gJHM and various anxiety disorders (e.g., panic, agoraphobia, social phobia) in seven pedigrees and in a sample of sporadic cases [Gratacòs et al, ]. Nevertheless, several following studies did not confirm such association [Schumacher et al, ; Tabiner et al, ; Henrichsen et al, ; Vermeulen et al, ]. Pathogenic processes underlying gJHM and JHS/EDS‐HT and psychopathological symptoms might be complex and imply different loci affecting growth, as well as having a pleiotropic effect on connective tissue structures and brain development and activity.…”

Section: Discussionmentioning

confidence: 99%

Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised

Sinibaldi

Ursini

Castori

2015

American J of Med Genetics Pt C

View full text Add to dashboard Cite

Psychological distress is a known feature of generalized joint hypermobility (gJHM), as well as of its most common syndromic presentation, namely Ehlers-Danlos syndrome, hypermobility type (a.k.a. joint hypermobility syndrome - JHS/EDS-HT), and significantly contributes to the quality of life of affected individuals. Most published articles dealt with the link between gJHM (or JHS/EDS-HT) and anxiety-related conditions, and a novel generation of studies is emerging aimed at investigating the psychopathologic background of such an association. In this paper, literature review was carried out with a semi-systematic approach spanning the entire spectrum of psychopathological findings in gJHM and JHS/EDS-HT. Interestingly, in addition to the confirmation of a tight link between anxiety and gJHM, preliminary connections with depression, attention deficit (and hyperactivity) disorder, autism spectrum disorders, and obsessive-compulsive personality disorder were also found. Few papers investigated the relationship with schizophrenia with contrasting results. The mind-body connections hypothesized on the basis of available data were discussed with focus on somatotype, presumed psychopathology, and involvement of the extracellular matrix in the central nervous system. The hypothesis of positive Beighton score and alteration of interoceptive/proprioceptive/body awareness as possible endophenotypes in families with symptomatic gJHM or JHS/EDS-HT is also suggested. Concluding remarks addressed the implications of the psychopathological features of gJHM and JHS/EDS-HT in clinical practice.

show abstract

“…The authors went on to demonstrate in an independent sample that DUP25 was present in a remarkable 97% of 70 unrelated PD patients and only 7% of 189 control subjects [22]. However, over the past year, other investigators have failed to detect DUP25 in different populations using a variety of methods in samples consisting of an aggregate total of 92 patients with PD or social phobia and 190 control subjects [23][24][25][26], and in samples provided by the authors of the original study [24,25,27]. The lack of replication in multiple studies casts serious doubt regarding DUP25 as a genetic mechanism in the etiology of panic and other anxiety disorders.…”

Section: Candidate Gene Studies In Panic Disordersmentioning

confidence: 94%

Genetics of anxiety disorders

Arnold

Zai²,

Richter

2004

Curr Psychiatry Rep

View full text Add to dashboard Cite

There is considerable evidence that genetic determinants play a major role in the etiology of anxiety. Investigations into susceptibility genes for anxiety are well underway, particularly for panic disorder and obsessive-compulsive disorder and more broadly defined anxiety-related traits, such as neuroticism and harm avoidance. This review will discuss some of the core issues related to diagnosis and molecular genetic methodology, followed by a review of recent molecular genetic findings for anxiety. The authors will attempt to highlight the numerous convergent and exciting findings. Given the rapid acceleration in knowledge of the human genome, a more definitive understanding of the genetic roots of these complex conditions may be anticipated in the relatively near future.

show abstract

No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach

Cited by 16 publications

References 8 publications

Joint hypermobility syndrome: problems that require psychological intervention

Joint hypermobility syndrome: problems that require psychological intervention

Psychopathological manifestations of joint hypermobility and joint hypermobility syndrome/ Ehlers–Danlos syndrome, hypermobility type: The link between connective tissue and psychological distress revised

Genetics of anxiety disorders

Contact Info

Product

Resources

About