No Evidence for Increased Risk of Cutaneous Squamous Cell Carcinoma in Patients With Rheumatoid Arthritis Receiving Etanercept for Up to 5 Years

Lebwohl, Mark; Blum, Robin R.; Berkowitz, Eric; Kim, Dennis; Zitnik, Ralph; Osteen, Cheri; Wallis, Wayne J.

doi:10.1001/archderm.141.7.861

Cited by 50 publications

(29 citation statements)

References 12 publications

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“…146 Controversy remains with regard to whether the observed higher incidences indicate additional risk due to TNF treatment, or whether they are in line with the increased risk of lymphoma observed in RA patients with high inflammatory activity. [147][148][149][150][151] In general, the incidence of other types of malignancies in TNF inhibitor-treated patients was found to be similar to, or lower than that observed in the general population 146,152,153 and other RA populations.…”

Section: Malignancies Including Lymphomasmentioning

confidence: 79%

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness

Chen

Jobanputra

Barton

et al. 2006

Health Technol Assess

325

261

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email.Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. Declared competing interests of authors: P Jobanputra is a Consultant Rheumatologist and a member of the British Society for Rheumatology. He has received funding for educational purposes from Abbott and Wyeth and has been entertained by manufacturers of all three TNF inhibitors. He has been involved in research studies of adalimumab and etanercept for rheumatoid arthritis and his department has received funding from Wyeth and Abbott for these studies. HTA Published November 2006This report should be referenced as follows:Chen Y-F, Jobanputra P, Barton P, Jowett S, Bryan S, Clark W, et al. A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness. Health Technol Assess 2006;10(42). Health Technology Assessment is indexed and abstracted in Index Medicus/MEDLINE, Excerpta Medica/EMBASE and Science Citation Index Expanded (SciSearch ® ) and Current Contents® /Clinical Medicine. NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of ...

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Section: Malignancies Including Lymphomasmentioning

confidence: 79%

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness

Chen

Jobanputra

Barton

et al. 2006

Health Technol Assess

325

261

View full text Add to dashboard Cite

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“…In patients with RA, etanercept use for as long as 5 years did not seem to be associated with an increase in the incidence of SCC. 20 Adverse events of interest that occurred in the study included 1 occurrence of B-cell chronic lymphocytic leukemia/small cell lymphocytic lymphoma, 1 occurrence of lymphocyte predominance type Hodgkin's disease, and 2 occurrences of worsening of congestive heart failure. There were no reports of demyelination, tuberculosis, or opportunistic infection.…”

Section: Commentmentioning

confidence: 99%

Long-term Safety and Efficacy of 50 mg of Etanercept Twice Weekly in Patients With Psoriasis

Tyring

Gordon²,

Poulin³

et al. 2007

Arch Dermatol

299

281

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“…Other studies based on retrospective analysis of clinical trials of etanercept and post marketing surveillance databases have supported these findings, showing a comparable incidence of SCC in etanercept-treated patients and in the general population. 135 Moreover, experimental studies in animal models showed that the inhibition of TNF does not promote skin carcinogenesis, but, instead, may impede tumorigenesis and have a protective action. 124,136,137 In a large US cohort of 15,789 patients with RA, compared with 3639 patients with osteoarthritis, a small but significant increased hazard (hazard ratio [HR],1.19) of developing NMSC was noted in RA patients compared with those with osteoarthritis, suggesting that the underlying disease itself and the degree of associated inflammation may predispose to skin cancer.…”

Section: Non-melanoma Skin Cancersmentioning

confidence: 99%

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

Moustou

Matekovits

Dessinioti

et al. 2009

Journal of the American Academy of Dermatology

172

108

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No Evidence for Increased Risk of Cutaneous Squamous Cell Carcinoma in Patients With Rheumatoid Arthritis Receiving Etanercept for Up to 5 Years

Cited by 50 publications

References 12 publications

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness

Long-term Safety and Efficacy of 50 mg of Etanercept Twice Weekly in Patients With Psoriasis

Cutaneous side effects of anti–tumor necrosis factor biologic therapy: A clinical review

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