No evidence for the involvement of the lipoxin A4 receptor (FPR2/ALX) gene in the susceptibility to coronary artery disease

Waechter, Vanessa; Marti-Jaun, Jacqueline; Weber, Angelika; Mádi, Z. L.; Hersberger, Martin

doi:10.1515/cclm.2011.738

Clinical Chemistry and Laboratory Medicine

2012

DOI: 10.1515/cclm.2011.738

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No evidence for the involvement of the lipoxin A4 receptor (FPR2/ALX) gene in the susceptibility to coronary artery disease

Vanessa Waechter¹,

Jacqueline Marti-Jaun²,

Angelika Weber³

et al.

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Polymorphisms Contributing to Calcium Status: A Systematic Review

Lopes

Abe²

2021

Nutrients

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This systematic review assessed genotypes and changes in calcium homeostasis. A literature search was performed in EMBASE, Medline and CENTRAL on 7 August 2020 identifying 1012 references. Studies were included with any human population related to the topic of interest, and genetic variations in genes related to calcium metabolism were considered. Two reviewers independently screened references, extracted relevant data and assessed study quality using the Q-Genie tool. Forty-one studies investigating Single Nucleotide Polymorphisms (SNPs) in relation to calcium status were identified. Almost half of the included studies were of good study quality according to the Q-Genie tool. Seventeen studies were cross-sectional, 14 case-control, seven association and three were Mendelian randomization studies. Included studies were conducted in over 18 countries. Participants were mainly adults, while six studies included children and adolescents. Ethnicity was described in 31 studies and half of these included Caucasian participants. Twenty-six independent studies examined the association between calcium and polymorphism in the calcium-sensing receptor (CASR) gene. Five studies assessed the association between polymorphisms of the Vitamin D receptor (VDR) gene and changes in calcium levels or renal excretion. The remaining ten studies investigated calcium homeostasis and other gene polymorphisms such as the CYP24A1 SNP or CLDN14. This study identified several CASR, VDR and other gene SNPs associated with calcium status. However, to provide evidence to guide dietary recommendations, further research is needed to explore the association between common polymorphisms and calcium requirements.

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Polymorphisms Contributing to Calcium Status: A Systematic Review

Lopes

Abe²

2021

Nutrients

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No evidence for the involvement of the lipoxin A4 receptor (FPR2/ALX) gene in the susceptibility to coronary artery disease

Cited by 1 publication

References 10 publications

Polymorphisms Contributing to Calcium Status: A Systematic Review

Polymorphisms Contributing to Calcium Status: A Systematic Review

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