No Evidence of Accelerated Loss of Kidney Function in Living Kidney Donors: Results From a Cross-Sectional Follow-Up1

Fehrman-Ekholm, Ingela; Dunér, Fredrik; Brink, Bo; Tydén, G; Elinder, Carl‐Gustaf

doi:10.1097/00007890-200108150-00015

Cited by 249 publications

(152 citation statements)

References 25 publications

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“…Outcome data from transplantation studies (20)(21)(22) have long supported that CKD after total nephrectomy is not a major concern in patients with two equivalent functioning kidneys and normal preoperative concentration of serum creatinine, since donors submitted to nephrectomy do not show decrease of their kidney function, kidney failure needing dialysis, or death. However, this is not observed in patients submitted to RN for cortical renal tumors.…”

Section: Discussionmentioning

confidence: 99%

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

et al. 2012

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ARTICLE INFO _________________________________________________________ ___________________Introduction: While some studies show that patients submitted to radical nephrectomy have a higher risk of developing chronic kidney disease (CKD), some studies report that carefully selected living kidney donors do not present a higher risk for CKD. Here, we aim to study predictive factors of CKD after radical nephrectomy. Materials and Methods: Between January 2006 to January 2010, 107 patients submitted to radical nephrectomy for cortical renal tumors at our institution were enrolled in this study. Demographic data were recorded, modified Charlson-Romano Index was calculated, and creatinine clearance was estimated using abbreviated Modification of Diet in Renal Disease (MDRD) study equation. Pathological characteristics, surgical access and surgical complications were also reviewed. The end-point of the current study was new onset estimated glomerular filtration rate (eGFR) less than 60 and less than 45 mL/minute/1.73 m 2 . Results: Age, preoperative eGFR, Charlson-Romano Index and hypertension were predictive factors of renal function loss, when the end-point considered was eGFR lower than 60 mL/minute/1.73 m

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Section: Discussionmentioning

confidence: 99%

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

et al. 2012

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“…In a Swedish study, the average estimated GFR (12 years after donation) was 72±18% of the age-predicted value. The ratio of the estimated to the predicted GFR showed no correlation to the time since donation, indicating that there is no accelerated loss of renal function after donation (Fehrman-Ekholm I, et al 2001 ). These results demonstrated that although living kidney donor lose GFR by 15-25%, they usually do not show the accelerated loss of renal function if they do not have risk factor for chronic renal disease (CKD).…”

Section: Renal Function Following Living Kidney Donationmentioning

confidence: 98%

“…Another study showed, in a live kidney donor cohort with a 93% retrieval rate of the 152 donors, fifty six percent of donors developed proteinuria (>150 mg/day), but only 10% had albuminuria (Gossmann J, et al 2005). By analysis of 402 outcome after donor nephrectomy in Sweden, significant proteinuria (> or =1.0 g/L) was found in 3% and slight proteinuria (<1.0 g/L) in 9% of the donors and proteinuria was associated with hypertension and a lower GFR (Fehrman-Ekholm I, et al 2001). One Meta-analysis, which analyzed a total of 5048 donors from forty-eight studies with an average follow-up of 7 years after donation (range 1-25 years), demonstrated that the average 24-h urine protein was 154 mg/day and concluded that kidney donation results in small increases in urinary protein.…”

Section: Proteinuria Following Living Kidney Donationmentioning

confidence: 99%

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Perioperative and Long-Term Safety of Living Kidney Donors

Okamoto¹

2011

Understanding the Complexities of Kidney Transplantation

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“…Az MDK-és IDK-betegcsoportok közötti különbség ellenére a folyamatosan bővülő transzplantációs várólis-ták szükségessé teszik a donorkritériumok kiterjesztését, és így a transzplantáció lehetőségét [12][13][14][15][16]. A dialízis-kezelésben részesülő betegek életminősége és hosszú távú túlélése rosszabb, mint a marginális donorokból származó vesével transzplantált betegeké.…”

Section: Megbeszélésunclassified

Banff-score-változások a marginális donorokból származó veséknél

et al. 2016

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Bevezetés: A transzplantációs várólistán szereplő betegek számának folyamatos növekedése miatt az ideális donor kritériumainak kibővítésére van szükség. Célkitűzés: A szerzők azt a kérdést vizsgálták, hogy vesetranszplantáció után egy és öt évvel van-e szignifikáns különbség a vesefunkcióban és/vagy -morfológiában a marginális és ideális donorból származó vesével rendelkező betegek között. Módszer: A vizsgálatba 275 beteget vontak be, közülük 97 marginális és 178 "ideális" veserecipiens volt. A marginális és az "ideális" veserecipiensek körében vizsgálták a donoralapadatokat és elemezték a transzplantáció után egy és öt évvel a funkcionális és hisztopatológiai változásokat. Eredmények: A graft funkcióját vizsgálva a transzplantáció után egy évvel nem volt különbség a két betegcsoport között, míg az ötödik évben a szérumkreatinin szignifikánsan magasabb (p = 0,0001) és a glomeruláris filtrációs ráta szignifikánsan alacsonyabb volt (p = 0,003) a marginális veserecipiensek csoportjában az ideális veserecipiensek csoportjához képest. A vese morfológiai elváltozásait vizsgálva már egy évvel a transzplantáció után a tubulitis (p = 0,014), valamint az interstitialis gyulladás (p = 0,025) szignifikánsan gyakoribb volt a marginális veserecipiensek csoportjában. Következ-tetés: A vesetranszplantáció után egy évvel a vese funkciójában még nincs szignifikáns különbség a marginális és "ideális" veserecipiensek között, de a szövettani elváltozásokban már szignifikáns különbség mutatkozik. Orv. Hetil., 2016, 157(8), 298-301. Kulcsszavak: marginális donor, ideális donor, vesetranszplantáció, Banff-score Banff score changes in kidneys from marginal donorsIntroduction: Despite an increase in the number of cadaver donors and the number of overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. Aim: The authors examined whether differences could exist in the function and/or morphology of transplanted kidneys originated from marginal and ideal donors one and five years after transplantation. Method: Kidney function and histopathologic findings were analysed and compared one and 5 years after transplantation in 97 patients having marginal donor kidneys and 178 patients who received ideal donor kidneys. Results: Serum creatinine level was significantly higher (p = 0.0001) and estimated glomerular filtration rate was significantly lower (p = 0.003) in patients having marginal donor kidneys as compared to those with ideal donor kidneys 5 years after transplantation. Morphological changes in the transplated kidneys such as tubulitis (p = 0.014) and interstitial inflammation (p = 0.025) were significantly more frequently present in patients with marginal donor kidneys than in those with ideal donor kidneys one year after transplantation. Conclusion: Despite an absence of differences in kidney function one year after kidney transplantation between patients having marginal and ideal donor kidneys, morphologic differences in the transplanted kidneys can be detected between t...

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No Evidence of Accelerated Loss of Kidney Function in Living Kidney Donors: Results From a Cross-Sectional Follow-Up1

Cited by 249 publications

References 25 publications

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

Can we predict which patients will evolve to chronic kidney disease after nephrectomy for cortical renal tumors?

Perioperative and Long-Term Safety of Living Kidney Donors

Banff-score-változások a marginális donorokból származó veséknél

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