No Evidence of Correlation between p53 Codon 72 Polymorphism and Risk of Bladder or Breast Carcinoma in Tunisian Patients

Mabrouk, Imed; Baccouche, Sami; El-Abed, Rym; Mokdad-Gargouri, Raja; Mosbah, A; Saïd, Salem; Daoud, J.; Frikha, M.; Jlidi, R.; Gargouri, Ali

doi:10.1196/annals.1299.137

Cited by 77 publications

(47 citation statements)

References 23 publications

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“…Association of Pro allele with increased risk of colorectal cancer has been reported in Japanese population (Hamajima et al, 2002), Korean population (Cao et al, 2009), in Chinese (Zhu et al, 2007) and in Malaysian population (Aizat et al, 2011). But for breast cancer risk no association of p.R72P polymorphism have been reported in Tunisian (Mabrouk et al, 2003) and Russian subjects (Suspitsin et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

Guleria¹,

Sharma²,

Manjari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 93%

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

Guleria¹,

Sharma²,

Manjari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…There was no association between the Arg/Arg genotype and breast carcinomas in patients from Russia (Suspitsin et al, 2003), Tunisia (Mabrouk et al, 2003) and Germany (Gohrke et al, 1998). Moreover, Pro/Pro genotype was more prevalent in Japanese (Noma et al, 2004) and in Swedish (Sjalander et al, 1996) women with breast cancer, as compared with normal controls (Damin et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

p53 Exon 4 (codon 72) Polymorphism and Exon 7 (codon 249) Mutation in Breast Cancer Patients in Southern Region(Madurai) of Tamil Nadu

Vijayaraman¹,

Veluchamy²,

Murugesan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: We investigated the association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk in women especially in the Southern part of India. Methods: Genotyping was performed for 50 breast cancer women and 50 controls to determine the status of p53 exon 4 codon 72 polymorphism and exon 7 codon 249 mutation and their possible role in breast cancer risk. Results: Frequency of Arg/Arg at codon 72 was 18% in controls and 28% in patients, Arg/Pro frequency was 56% and 66% , Pro/Pro genotype was 8% in controls and 8% in patients. No significance was observed for breast cancer risk with either Arg/Arg or Pro/ Pro genotype in codon 72 polymorphism. Similarly, mutation analysis of exon 7 codon 249 revealed that 72% of breast cancer patients have mutation, which is not statistically significant. However, there is a strong association between increase in exon 7 codon 249 mutation and exposure to pollution. Conclusion: The results suggested that there is no risk for exon 4 with Arg/Arg or Pro/Pro polymorphisms in the p53 gene and there is no strong correlation between breast cancer patients and mutation in exon 7 codon 249 in South Indian women.Keywords: Breast cancer -p53 -exon 4 codon 72 -exon 7 codon 249 -South India

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“…There were a few other studies addressing the role of p53 polymorphisms in other tobacco-related cancers. However, the associations were not consistent Mabrouk et al, 2003). p21: The association of p21 codon 31 (Ser31Arg) polymorphism with cancer risk has been examined in three lung cancer studies.…”

Section: Cell-cycle Checkpointmentioning

confidence: 99%

Genetic susceptibility to tobacco-related cancer

et al. 2004

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Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a small fraction of individuals with tobacco exposure develop cancer. The underlying hypothesis is that genetic factors may render certain smokers more susceptible to cancer than others. Genetic alterations in critical regulatory pathways may predispose cells to carcinogenesis. These pathways include regulation of xenobiotic metabolism; control of genomic stability, including DNA repair mechanisms, cell-cycle checkpoints, apoptosis and telomere length; and control of microenvironmental factors, such as matrix metalloproteinases, inflammation and growth factors. In addition, epigenetic events, such as promoter hypermethylation and loss of imprinting, are also involved in carcinogenesis. In this review, we will summarize recent advances in genetic susceptibility to tobacco-related cancer. Emphasizing on risk assessment, we will describe how genetic variations in the above-mentioned genetic pathways modify the tobacco-related cancer risk. In addition, we will discuss how genetic variations may assist in predicting clinical outcome, such as the natural history of cancer and treatment response. The measurements of genetic susceptibility by both genotypic and phenotypic assays are covered in the text. Finally, we present a number of current concerns that need to be addressed as the exciting field of molecular cancer epidemiology advances rapidly.

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No Evidence of Correlation between p53 Codon 72 Polymorphism and Risk of Bladder or Breast Carcinoma in Tunisian Patients

Cited by 77 publications

References 23 publications

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

p.R72P, PIN3 Ins16bp Polymorphisms of TP53 and CCR5Δ32 in North Indian Breast Cancer Patients

p53 Exon 4 (codon 72) Polymorphism and Exon 7 (codon 249) Mutation in Breast Cancer Patients in Southern Region(Madurai) of Tamil Nadu

Genetic susceptibility to tobacco-related cancer

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