No Evidence of HSV Presence in the Serum of Vitiligo Patients

Liu, Zhe; Qi, Ruomei

doi:10.4172/2376-0427.1000105

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…failed to detect anti-IgG antibodies against the HSV-1/2 in 90 patients with vitiligo compared to 150 pregnant women who served as controls. [ 18 ] However, more recently, Lan et al . provided evidence that HSV-1 enters the melanocytes and induces apoptosis, leading to their hypothesis that HSV-1 infection might be a trigger for vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Serum Immunoglobulin G (IgG) Levels against Toxoplasma Gondii, Herpes Simplex Virus Types 1 and 2, Cytomegalovirus and Hepatitis C Virus in Vitiligo

Ribeiro,

Lacerda,

Guillo

2023

Indian Journal of Dermatology

View full text Add to dashboard Cite

Background: Pathogen infections have been associated with autoimmunity, which in turn has been implicated in the pathogenesis of vitiligo. However, the association between pathogen infections and vitiligo remains elusive. Aims: This study aimed to assess the proportion of individuals who tested positive for specific IgG antibodies against selected pathogens in patients with vitiligo and control subjects. Materials and Methods: Plasma from 51 patients with vitiligo and 51 age- and gender-matched controls were tested for anti-Toxoplasma gondii (T. gondii) IgG, anti-herpes simplex types 1 and 2 (HSV-1/2) IgG, anti-cytomegalovirus (CMV) IgG and anti-hepatitis C virus IgG. Results: Among all participants (n = 102), 63%, 84% and 87% tested positive for anti-T. gondii, anti-HSV-1/2 and anti-CMV IgG antibodies, respectively. Anti-hepatitis C virus IgG was negative in all samples tested. Positive anti-T. gondii IgG was detected in plasma samples of 39 (78%) patients with vitiligo and 25 (49%) controls (odds ratio [OR] 3.68, 95% confidence interval [CI] 1.55–8.76, P = 0.0036). Anti-HSV-1/2 IgG was detected in samples of 47 (92%) patients with vitiligo and 38 (76%) controls (OR 3.71, 95% CI 1.11–12.44, P = 0.031). Differences in frequencies of positive results for anti-T. gondii IgG and anti-HSV-1/2 IgG were only significant in samples from female patients with vitiligo when compared with controls (P = 0.036 and 0.024, respectively). Anti-CMV IgG was detected in samples from 46 patients with vitiligo (90%) and 41 (84%) controls (P = 0.384). Conclusions: T. gondii IgG and HSV-1/2 IgG were significantly more frequent in patients with vitiligo, especially in women, when compared with age- and gender-matched controls. Since T. gondii and HSV-1/2 infections can trigger autoimmune events, past exposure to these pathogens may be a risk factor for the development of vitiligo.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of Serum Immunoglobulin G (IgG) Levels against Toxoplasma Gondii, Herpes Simplex Virus Types 1 and 2, Cytomegalovirus and Hepatitis C Virus in Vitiligo

Ribeiro,

Lacerda,

Guillo

2023

Indian Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…The virus can also attract leucocytes and macrophages leading in turn to the 'oxygen burst' via NADPH-oxidase concomitant with the production of ROS (such as superoxide radicals, H2O2), thus generating ROS pool in vitiligo. The association of vitiligo with such virus and/or viral diseases has been shown in Table 1 [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. However, few studies deny the involvement of virus in vitiligo pathogenesis [21,25].…”

mentioning

confidence: 99%

Viral causes of Vitiligo: A New Perspective for Vitiligo Pathogenesis

Dwivedi¹

2018

VIJ

View full text Add to dashboard Cite

Vitiligo is an acquired skin depigmenting disorder due to loss of functional melanocytes in the epidermis. Several hypotheses have been proposed to explain its etiopathogenesis; however autoimmune pathomechanisms have been suggested to play an important role in the disease development. Previously, the viral causes of vitiligo have been suggested to be involved in vitiligo pathogenesis, however at present there are no such studies available to elucidate the role of viruses in inducing autoimmune mechanisms in vitiligo. The current article briefly summarizes all previous and currently available such studies involving viruses in vitiligo pathogenesis. The vitiligo being a complex autoimmune disorder and an important disease of research opens a new way to look at the virus based autoimmune mechanisms to cause vitiligo. Short Communication Vitiligo is an acquired, progressive, multifactorial, depigmenting disorder characterized by the appearance of circumscribed white macules in the skin due to chronic, progressive loss of functional melanocytes in the epidermis [1] (Figure 1). The selective destruction of melanocytes results in the development of depigmented patches. As such vitiligo is hardly a disease of medical significance but there is more of a social stigma attached to it because of cosmetic reasons. Although it might be viewed as minor disorder, these patches gradually increase in size and cause lot of psychological stress in the patient, self esteem and social interactions, particularly in patients with deeply pigmented skin [2]. The prevalence studies revealed that the worldwide prevalence of vitiligo ranges between 0.5 and 2% [3]. Based on a few dermatological outpatient records the prevalence of vitiligo in India is found to be 0.46% to 8.8% [4].

show abstract