No evidence of West Nile virus infection in Dutch blood donors

Koppelman, Marco; Sjerps, Margret; Waal, Mirjam de; Reesink, H. W.; Cuypers, H. T. M.

doi:10.1111/j.1423-0410.2006.00754.x

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…This outcome is in accordance with the recent WNV-RNA screening results of more than 60,000 Dutch blood donors [Koppelman et al, 2006]. Regardless, blood donors who had just recently visited a WNV endemic country (e.g., the USA) are excluded from the actual donation as a precautionary measure in German blood banks.…”

Section: Wnv-rna Incidencesupporting

confidence: 52%

West Nile virus and blood product safety in Germany

Pfleiderer

Blümel

Schmidt

et al. 2008

Journal of Medical Virology

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West Nile Virus (WNV) is a mosquito-transmitted flavivirus, widely distributed throughout Africa, Asia and the Middle East. WNV may cause epidemics of human meningoencephalitis. The unexpected emergence of WNV (New York, 1999) and its rapid spread throughout North America during the following years caused a number of blood transfusion- and organ transplant-associated transmissions of WNV. In order to estimate the potential WNV threat for Central Europe, we analyzed the anti-WNV prevalence and WNV-RNA incidence among 14,437 and 9,976 blood donors from Germany. There was a high rate of initially anti-WNV reactives (5.9%), but only a few cases (0.03%) were confirmed as anti-WNV positive by neutralization assay. No WNV-RNA positive blood donor was identified in this study. Whereas WNV-RNA was frequently detected in manufacturing plasma pools from the US, none was detected in pools of European or Asian origin. Virus inactivation steps integrated into the manufacturing process of plasma derivatives were shown to be sufficient to assure the WNV safety of plasma derivatives. A well-characterized WNV reference material was prepared, showing 340 WNV-RNA copies per infectious dose.

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Section: Wnv-rna Incidencesupporting

confidence: 52%

West Nile virus and blood product safety in Germany

Pfleiderer

Blümel

Schmidt

et al. 2008

Journal of Medical Virology

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“…Evidence of WNV circulation among birds has been reported in the UK since 2003, and in 2006 the use of sentinel chickens corroborated the epidemiological data about WNV in the UK by demonstrating actual seroconversion [18,19]. As far as the remaining European countries are concerned, reports indicated that blood donors were seronegative for WNV in Tyrol, Austria [20] and in The Netherlands [21], whereas the prevalence of anti-WNV neutralizing antibodies was very low (0.03%) among blood donors in Germany. Nevertheless, a recent evaluation of immunoglobulin preparations produced from human plasma collected in Austria, Germany and the Czech Republic indicated increasing WNV antibody titres in preparations from 2009 and 2010, suggesting past WNV exposure of just under 1% of the population of these three central European countries [22].…”

Section: Epidemiology Of Wnv In Eu Member Countries and Neighbouring mentioning

confidence: 89%

West Nile virus in Europe: emergence, epidemiology, diagnosis, treatment, and prevention

Sambri

Capobianchi²,

Charrel

et al. 2013

Clinical Microbiology and Infection

161

130

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West Nile virus (WNV), a mosquito-borne flavivirus in the Japanese encephalitis antigenic group, has caused sporadic outbreaks in humans, horses and birds throughout many of the warmer regions of Europe for at least 20 years. Occasional cases of West Nile encephalitis have also been associated with infected blood transfusions and organ donations. Currently, WNV appears to be expanding its geographical range in Europe and causing increasing numbers of epidemics/outbreaks associated with human morbidity and mortality. This brief review reports on the current epidemic situation regarding WNV in Europe, highlighting the clinical, diagnostic and preventive measures available for controlling this apparently emerging human pathogen.

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“…The relatively high initial reactive rate of blood samples (0.24%) and invalid rate (0.9%) has not been a serious concern, as comparable results have also been reported in similar studies conducted in Mexico (Sánchez‐Guerero et al ., 2006) and the Netherlands (Koppelman et al ., 2006), respectively. In our opinion, in countries with low prevalence of WNV such as Greece, initial reactive blood donations detected by PCR assays should not be excluded from blood supply unless their reactivity is replicated by the same or another method.…”

Section: Discussionmentioning

confidence: 99%

Searching for West Nile virus (WNV) in Greece

Καντζάνου¹,

Moschidis²,

Kremastinou

et al. 2010

Transfusion Medicine

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West Nile virus (WNV), a mosquito-borne flavivirus, has increasingly become a concern in both America and Europe due to its complex and unpredictable lifecycle. Transfusion-associated transmission of the WNV has been well documented during the last few years. This study aimed to detect the presence of WNV in: (i) cerebrospinal fluid (CSF) specimens derived from aseptic meningitis cases in Greece and (ii) Greek blood donations. A total of 115 CSF specimens from patients suffering from aseptic meningitis and 9590 blood samples were collected from seven Greek hospitals during the periods June to October 2006 and 2007 and tested for investigational purposes. Both blood and CSF samples were tested for the presence of WNV RNA by using the PROCLEIX WNV assay. None of 115 CSF and 9590 blood donor samples was found positive according to our testing algorithms. Despite the presence of WNV in Balkan countries, WNV has not reached significant levels in Greece.

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No evidence of West Nile virus infection in Dutch blood donors

Abstract: No evidence of the presence of WNV RNA in Dutch blood donor samples from 2004 was found. However, surveillance of this emerging infection is of importance to safeguard the blood supply in the future because the transmission cycle of WNV is complex and hard to predict.

Cited by 8 publications

References 16 publications

West Nile virus and blood product safety in Germany

West Nile virus and blood product safety in Germany

West Nile virus in Europe: emergence, epidemiology, diagnosis, treatment, and prevention

Searching for West Nile virus (WNV) in Greece

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