No evidence that wheel-running exercise impacts cocaine conditioned place preference in male C57BL/6J mice

Lespine, Louis‐Ferdinand; Tirelli, Ezio

doi:10.1016/j.bbr.2019.03.002

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…In contrast with the converging evidence that increased AHN reduces cocaine selfadministration, when AHN-enhancing interventions are used as a 'preventive' approach before a cocaine CPP paradigm, reduced [41,43], unchanged [44,45]…”

Section: Processing Of Cocaine-related Memoriesmentioning

confidence: 85%

“…increased [46] cocaine CPP have been reported. The reason for these conflicting findings is unclear, although the use of (male) rodents of different strains and species may have contributed to the variability among studies [41,[43][44][45]. Another possibility is that because increasing AHN may potentiate hippocampus-dependent contextual and associative memory [47], enhanced cognition may modulate the expression of the CPP response, independently of drug motivation and reward [17,31] (Figure 2).…”

Section: And Evenmentioning

confidence: 99%

See 1 more Smart Citation

Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments

Castilla‐Ortega

Santín

2020

Current Opinion in Pharmacology

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Section: Processing Of Cocaine-related Memoriesmentioning

confidence: 85%

Section: And Evenmentioning

confidence: 99%

Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments

Castilla‐Ortega

Santín

2020

Current Opinion in Pharmacology

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“…Also, other studies found that EE (including access to a running wheel), when introduced before conditioning, actually strengthened nicotine (Ewin et al 2015), morphine (Eisenstein and Holmes 2007) or cocaine CPP (Smith et al 2008) and delayed the extinction of CPP (Mustroph et al 2011). A very recent study found no evidence of wheel running during rearing on the development of cocaine CPP in mice (Lespine and Tirelli 2019). Thus, the power of EE as a preventative intervention against the development of CPP remains inconclusive and warrants further studies.…”

Section: Conditioned Place Preferencementioning

confidence: 99%

Therapeutic efficacy of environmental enrichment for substance use disorders

Galaj

Barrera

Ranaldi

2020

Pharmacology Biochemistry and Behavior

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“…Here, we show that cocaine exposure during adolescence desensitizes adult animals to a rewarding dose of cocaine (10 mg/kg), 39,40 independently from the contingency versus non‐contingency of cocaine exposure (SA vs. YC). In fact, it was sufficient to increase the dose of cocaine to drive CPP, suggesting that cocaine SA during adolescence might have moved the rewarding threshold higher for cocaine‐CPP in adulthood .…”

Section: Discussionmentioning

confidence: 80%

Repeated exposure to cocaine during adolescence enhances the rewarding threshold for cocaine‐conditioned place preference in adulthood

et al. 2021

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Previous studies have shown that adolescent exposure to cocaine increases drug use in adulthood, albeit incubation of cocaine seeking was found to be attenuated in rats trained to self‐administer cocaine during adolescence. We here hypothesize that adolescent exposure to cocaine could alter the rewarding properties of the psychostimulant in adulthood. By employing two of the most widely used animal‐experimental‐preclinical models to investigate drug addiction, we evaluated whether contingent versus non‐contingent cocaine self‐administration during adolescence modulates its rewarding threshold in adulthood evaluated by conditioned place preference (CPP). Cocaine self‐administration during adolescence increases the rewarding threshold in adulthood; CPP for cocaine was observed at the higher (20 mg/kg), but not at the lower (10 mg/kg), dose employed. Rats exposed to either contingent or non‐contingent cocaine during adolescence exhibited the same behavior in the CPP paradigm suggesting that, under our experimental conditions, cocaine rewarding properties are shaped by the psychostimulant itself and not by its motivational effects. From a mechanistic standpoint, the preference for the 20 mg/kg cocaine‐paired side in a CPP paradigm appears to depend, at least partially, upon the formation of GluA2‐lacking Ca2+‐permeable AMPA receptors and the consequent increase of αCaMKII activity in the NAc, both of which are instead reduced when the 10 mg/kg dose was used. In conclusion, contingent or non‐contingent cocaine exposure during adolescence desensitizes adult animals to a rewarding dose of cocaine (10 mg/kg) elevating the rewarding threshold necessary (20 mg/kg) to drive conditioned place preference, an effect that may predispose to higher consumption of cocaine during adulthood.

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No evidence that wheel-running exercise impacts cocaine conditioned place preference in male C57BL/6J mice

Cited by 6 publications

References 15 publications

Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments

Adult hippocampal neurogenesis as a target for cocaine addiction: a review of recent developments

Therapeutic efficacy of environmental enrichment for substance use disorders

Repeated exposure to cocaine during adolescence enhances the rewarding threshold for cocaine‐conditioned place preference in adulthood

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