No Holes Barred: Invasion of the Intestinal Mucosa by Mycobacterium avium subsp. paratuberculosis

Bannantine, John P.; Bermudez, Luiz E.

doi:10.1128/iai.00575-13

Cited by 46 publications

(50 citation statements)

References 55 publications

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“…Of the 22 positional candidate genes identified in the 47 identified QTL, 10 were identified as potential functional candidate genes based upon their gene ontology results and previous reports on their function in the literature (Bannantine and Bermudez, 2013;Liu et al, 2013;Marton et al, 2015). Some of these genes are novel in the sense that they have not previously been associated with bovine paratuberculosis.…”

Section: Candidate Genes Associated With Humoral Response To Mapmentioning

confidence: 99%

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

McGovern

Purfield

Ring

et al. 2019

Journal of Dairy Science

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Infection of cattle with bovine paratuberculosis (i.e., Johne's disease) is caused by Mycobacterium avium ssp. paratuberculosis (MAP) and results in a chronic incurable gastroenteritis. This disease, which has economic ramifications for the cattle industry, is increasing in detected prevalence globally; subclinically infected animals can silently shed the bacterium into the environment for years, exposing contemporaries and hampering disease-control programs. The objective of the present study was to first quantify the genetic parameters for humoral response to MAP in dairy cattle. This was followed by a genome-based association analysis and subsequent downstream bioinformatic analyses from imputed whole genome sequence SNP data. After edits, ELISA test records were available on 136,767 cows; analyses were also undertaken on a subset of 33,818 of these animals from herds with at least 5 MAP ELISApositive cows, with at least 1 of those positive cows being homebred. Variance components were estimated using univariate animal and sire linear mixed models. The heritability calculated from the animal model for humoral response to MAP using alternative phenotype definitions varied from 0.02 (standard error = 0.003) to 0.05 (standard error = 0.008). The genome-based associations were undertaken within a mixed model framework using weighted deregressed estimated breeding values as a dependent variable on 1,883 phenotyped animals that were ≥87.5% Holstein-Friesian. Putative susceptibility quantitative trait loci (QTL) were identified on Bos taurus autosome 1,

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Section: Candidate Genes Associated With Humoral Response To Mapmentioning

confidence: 99%

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

McGovern

Purfield

Ring

et al. 2019

Journal of Dairy Science

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“…Following ingestion MAP is internalized in the small intestine of ruminants by microfold cells (M cells) or by enterocytes. It can then be carried by dendritic cells or macrophages to mesenteric or regional lymph nodes [24]. Entry of MAP into bovine Peyer’s patch tissue is followed by suppression of genes that maintain intestinal barriers such as those controlling tight junctions, gap junctions, and adherens junctions [25].…”

Section: Map Infection Of Ruminantsmentioning

confidence: 99%

Mycobacterium paratuberculosis as a cause of Crohn’s disease

McNees

Markesich

Zayyani

et al. 2015

Expert Review of Gastroenterology & Hepatology

127

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SUMMARY Crohn's disease is a chronic inflammatory bowel disease of unknown cause, affecting approximately 1.4 million North American people. Due to the similarities between Crohn's disease and Johne’s disease, a chronic enteritis in ruminant animals caused by Mycobacterium avium paratuberculosis (MAP) infection, MAP has long been considered to be a potential cause of Crohn's disease. MAP is an obligate intracellular pathogen that cannot replicate outside of animal hosts. MAP is widespread in dairy cattle and because of environmental contamination and resistance to pasteurization and chlorination, humans are frequently exposed through contamination of food and water. MAP can be cultured from the peripheral mononuclear cells from 50 to 100% of patients with Crohn's disease, and less frequently from healthy individuals. Association does not prove causation. We discuss the current data regarding MAP as a potential cause of Crohn's disease and outline what data will be required to firmly prove or disprove the hypothesis.

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“…Passage of MAP through the ruminant digestive system activates the bacterial cell wall protein fibronectin attachment protein (FAP) to promote opsonization by fibronectin [32]. Fibronectin, in turn, links MAP to the luminal surface of intestinal M cells through fibronectin receptors.…”

Section: Stages Of Map Infectionmentioning

confidence: 99%

From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis

Arsenault

Määttänen

Daigle

et al. 2014

Vet Res

109

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Johne’s disease (JD) is a chronic enteric infection of cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP). The high economic cost and potential zoonotic threat of JD have driven efforts to develop tools and approaches to effectively manage this disease within livestock herds. Efforts to control JD through traditional animal management practices are complicated by MAP’s ability to cause long-term environmental contamination as well as difficulties associated with diagnosis of JD in the pre-clinical stages. As such, there is particular emphasis on the development of an effective vaccine. This is a daunting challenge, in large part due to MAP’s ability to subvert protective host immune responses. Accordingly, there is a priority to understand MAP’s interaction with the bovine host: this may inform rational targets and approaches for therapeutic intervention. Here we review the early host defenses encountered by MAP and the strategies employed by the pathogen to avert or subvert these responses, during the critical period between ingestion and the establishment of persistent infection in macrophages.

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No Holes Barred: Invasion of the Intestinal Mucosa by Mycobacterium avium subsp. paratuberculosis

Cited by 46 publications

References 55 publications

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

Candidate genes associated with the heritable humoral response to Mycobacterium avium ssp. paratuberculosis in dairy cows have factors in common with gastrointestinal diseases in humans

Mycobacterium paratuberculosis as a cause of Crohn’s disease

From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis

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