NO-HYPE: a novel hydrodynamic phantom for the evaluation of MRI flow measurements

Gadda, Giacomo; Cocozza, Sirio; Gambaccini, M.; Taibi, Angelo; Tedeschi, Enrico; Zamboni, Paolo; Palma, Giuseppe

doi:10.1007/s11517-021-02390-2

Cited by 4 publications

(4 citation statements)

References 41 publications

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“… 48 Our design combining an anthropomorphic liver phantom with pulsatile flow resembles a phantom recently used to test multimodal image‐guided liver therapy techniques, 49 a phantom that simulates heart, lung, and blood motion for the validation of MR‐based endovascular interventional techniques, 50 and the hydrodynamic phantoms developed for the MR evaluation of blood flows. 51 …”

Section: Discussionmentioning

confidence: 99%

“…A multitude of static phantoms 43 have been developed to achieve a wide range of ADC measurements on MRI systems using polyvinylpyrrolidone solutions, 44 sucrose solutions, 45 alkanes, 46 copper sulfate, 47 acetone, and deuterium oxide 48 . Our design combining an anthropomorphic liver phantom with pulsatile flow resembles a phantom recently used to test multimodal image‐guided liver therapy techniques, 49 a phantom that simulates heart, lung, and blood motion for the validation of MR‐based endovascular interventional techniques, 50 and the hydrodynamic phantoms developed for the MR evaluation of blood flows 51 …”

Section: Discussionmentioning

confidence: 99%

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Motion‐robust, blood‐suppressed, reduced‐distortion diffusion MRI of the liver

Geng

Zhang

Rice

et al. 2022

Magnetic Resonance in Med

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Purpose To evaluate feasibility and reproducibility of liver diffusion‐weighted (DW) MRI using cardiac‐motion‐robust, blood‐suppressed, reduced‐distortion techniques. Methods DW‐MRI data were acquired at 3T in an anatomically accurate liver phantom including controlled pulsatile motion, in eight healthy volunteers and four patients with known or suspected liver metastases. Standard monopolar and motion‐robust (M1‐nulled, and M1‐optimized) DW gradient waveforms were each acquired with single‐shot echo‐planar imaging (ssEPI) and multishot EPI (msEPI). In the motion phantom, apparent diffusion coefficient (ADC) was measured in the motion‐affected volume. In healthy volunteers, ADC was measured in the left and right liver lobes separately to evaluate ADC reproducibility between the two lobes. Image distortions were quantified using the normalized cross‐correlation coefficient, with an undistorted T2‐weighted reference. Results In the motion phantom, ADC mean and SD in motion‐affected volumes substantially increased with increasing motion for monopolar waveforms. ADC remained stable in the presence of increasing motion when using motion‐robust waveforms. M1‐optimized waveforms suppressed slow flow signal present with M1‐nulled waveforms. In healthy volunteers, monopolar waveforms generated significantly different ADC measurements between left and right liver lobes (p=0.0078$$ p=0.0078 $$, reproducibility coefficients (RPC) = 470prefix×10prefix−6$$ 470\times 1{0}^{-6} $$ mm2$$ {}^2 $$/s for monopolar‐msEPI), while M1‐optimized waveforms showed more reproducible ADC values (p=0.29$$ p=0.29 $$, RPC=220prefix×10prefix−6$$ \mathrm{RPC}=220\times 1{0}^{-6} $$ mm2$$ {}^2 $$/s for M1‐optimized‐msEPI). In phantom and healthy volunteer studies, motion‐robust acquisitions with msEPI showed significantly reduced image distortion (p<0.001$$ p<0.001 $$) compared to ssEPI. Patient scans showed reduction of wormhole artifacts when combining M1‐optimized waveforms with msEPI. Conclusion Synergistic effects of combined M1‐optimized diffusion waveforms and msEPI acquisitions enable reproducible liver DWI with motion robustness, blood signal suppression, and reduced distortion.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Motion‐robust, blood‐suppressed, reduced‐distortion diffusion MRI of the liver

Geng

Zhang

Rice

et al. 2022

Magnetic Resonance in Med

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“…However, due to the lack of knowledge about the accuracy of PC-MRI measurements, its implementation in clinical practice has been retarded [ 61 , 62 ]. To address this issue, Gadda and collaborators [ 63 ] developed and validated an MRI-compatible hydrodynamic phantom to understand, test, and optimize PC-MRI measurements. As the relaxation time value is a crucial parameter to be considered in the design of biomimicking MRI models, the authors have selected a water solution of CuSO 4 with a relaxation time value similar to those of human soft tissues at clinical magnetic field intensities.…”

Section: Applications Of Biomimetic Vascular Models For Atherosclerosismentioning

confidence: 99%

“…Simulated fluid was produced by an external company and had the same magnetic properties as human blood. Some imaging errors were observed, suggesting the capability of the phantom to accurately detect error sources, which must be corrected and adjusted [ 63 ]. This phantom was a robust standardization tool to calibrate MRI systems, which is fundamental for implementing these systems in clinical practice.…”

Section: Applications Of Biomimetic Vascular Models For Atherosclerosismentioning

confidence: 99%

Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic

Henriques,

Amaro,

Piedade

2024

Biomimetics

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Atherosclerosis represents the etiologic source of several cardiovascular events, including myocardial infarction, cerebrovascular accidents, and peripheral artery disease, which remain the leading cause of mortality in the world. Numerous strategies are being delineated to revert the non-optimal projections of the World Health Organization, by both designing new diagnostic and therapeutic approaches or improving the interventional procedures performed by physicians. Deeply understanding the pathological process of atherosclerosis is, therefore, mandatory to accomplish improved results in these trials. Due to their availability, reproducibility, low expensiveness, and rapid production, biomimicking physical models are preferred over animal experimentation because they can overcome some limitations, mainly related to replicability and ethical issues. Their capability to represent any atherosclerotic stage and/or plaque type makes them valuable tools to investigate hemodynamical, pharmacodynamical, and biomechanical behaviors, as well as to optimize imaging systems and, thus, obtain meaningful prospects to improve the efficacy and effectiveness of treatment on a patient-specific basis. However, the broadness of possible applications in which these biomodels can be used is associated with a wide range of tissue-mimicking materials that are selected depending on the final purpose of the model and, consequently, prioritizing some materials’ properties over others. This review aims to summarize the progress in fabricating biomimicking atherosclerotic models, mainly focusing on using materials according to the intended application.

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