2018
DOI: 10.1093/ofid/ofy192
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No Impact of Probiotics to Reduce Clostridium difficile Infection in Hospitalized Patients: A Real-world Experience

Abstract: We assessed the effectiveness of a Lactobacillus probiotic on rates of health care facility–onset Clostridium difficile infection (HO-CDI) in patients receiving antibiotics. A total of 1576 patients were evaluated. There was no difference in the HO-CDI incidence between those who received probiotics and those who did not (1.8% vs 0.9%; P = .16).

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Cited by 18 publications
(28 citation statements)
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“…For example, probiotics that were not according to a doctor's recommended dosage. There were some patients who had not only received probiotics but they had also received a high dosage of antibiotics so the probiotics given at the time no longer have an effect (Box, Ortwine, & Goicoechea, 2016). Another thing to consider is that the number of study participants was 80.5% for those not eligible and the patients who were eligible may have been relatively healthy.…”
Section: Discussionmentioning
confidence: 99%
“…For example, probiotics that were not according to a doctor's recommended dosage. There were some patients who had not only received probiotics but they had also received a high dosage of antibiotics so the probiotics given at the time no longer have an effect (Box, Ortwine, & Goicoechea, 2016). Another thing to consider is that the number of study participants was 80.5% for those not eligible and the patients who were eligible may have been relatively healthy.…”
Section: Discussionmentioning
confidence: 99%
“…Nor did the use of probiotics appear to affect usage of CDI treatment antibacterials. Recently, other researchers failed to find lower rates of CDI with the Bio-K+ probiotic (Allen et al, 2013; Box et al, 2018). These findings do not necessarily mean that the probiotics did not help some individuals.…”
Section: Discussionmentioning
confidence: 99%
“…The inclusion of low-risk patients was suggested as a limitation in other studies not showing a preventive effect. The best examples can be seen in the PLACIDE study conducted in the UK and in many of the small studies included in the various meta-analyses (Allen et al, 2013; Box et al, 2018; Johnston et al, 2018). In addition to having a large proportion of low-risk patients, the PLACIDE study also allowed patients to start probiotics up to a week after the start of antibacterials (Allen et al, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…The concept of promoting human health through consumption of beneficial microorganisms has evolved during the last century ( George Kerry et al., 2018 ). Numerous studies have been published under this broad definition, attempting to demonstrate beneficial effects of probiotics to CDI, however, with highly mixed results ( Na and Kelly, 2011 ; Shen et al., 2017 ; Box et al., 2018 ). The considerable variation in outcomes between clinical trials may be attributed to multiple factors, including differences in the bacterial strains used among researchers and the survivability of the studied microorganisms in different individuals' gut microenvironment.…”
Section: Introductionmentioning
confidence: 99%