No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial

Larsen, Anette Uhlving; Hopstock, Laila Arnesdatter; Jorde, Rolf; Grimnes, Guri

doi:10.1016/j.sleepx.2021.100040

Cited by 9 publications

(3 citation statements)

References 49 publications

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“…However, this matter is still debatable as vitamin D supplementation might not show notable improvement in sleep quality, as observed in similar studies. 32 Considering these contradictory results, we suggest a better interventional study involving multiple centres, as the present study showed some technical setbacks. As a cross-sectional study with a small sample size, not only could it establish a causal relationship between observed variables, it didn't rule out a possible bidirectional relationship either.…”

Section: Discussionmentioning

confidence: 67%

Melody of sleep by sun: Association between serum vitamin D levels and sleep quality in ESRD patients.

Fatima,

Rashid,

Nasim

et al. 2023

JSTMU

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Background: Hemodialysis (HD) is a commonly employed treatment modality for chronic kidney disease (CKD) patients. It is also closely related to the sleep-wake cycle. It has both sleep-improving and deteriorating results. Sleep regulation is tightly coupled to vitamin D; hence, its deficiency might impact the duration and quality of sleep. This study intends to evaluate the association between sleep quality and serum vitamin D levels in HD patients. Objective: To assess the quality of sleep in patients with ESRD on routine HD and determine the association of vitamin D deficiency with sleep quality. Methodology: This cross-sectional analytical study was conducted on the patients presenting to the dialyzing centre of the Department of Nephrology, Holy Family Hospital, Rawalpindi, Pakistan, for twice-weekly routine hemodialysis, from May 2022 to June 2022. Results: In this study, the quality of sleep in End Stage Renal Disease (ESRD) patients on twice-weekly hemodialysis (HD) was assessed using the PSQI score. PSQI scores were associated with serum vitamin D levels in these patients. A significantly strong positive correlation existed between serum levels of 25-OH D and sleep quality (r = −0.468, p = 0.001). Conclusion: More than half of the patients undergoing routine hemodialysis could not sleep well at night. Among other related factors, vitamin D deficiency was an independent risk factor for poor sleep quality. Further studies are needed to determine the impact of vitamin D supplementation on improving sleep quality to strengthen the association between vitamin D levels and sleep disorders.

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Section: Discussionmentioning

confidence: 67%

Melody of sleep by sun: Association between serum vitamin D levels and sleep quality in ESRD patients.

Fatima,

Rashid,

Nasim

et al. 2023

JSTMU

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“…6 nmol/L (31.2 ± 16.2 ng/mL) after 12 weeks) [87]. Regarding sleep quality, there is no evidence from RCTs for any beneficial effect of vitamin D supplementation, without any difference according to baseline vitamin D status [88,89].…”

Section: Menopausal Symptomatologymentioning

confidence: 99%

Vitamin D, Menopausal Health and COVID-19: Critical Appraisal of Current Data

Anagnostis

Livadas

Goulis

et al. 2023

JCM

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Inconsistency exists across studies conducted in postmenopausal women regarding the effect of vitamin D deficiency (VDD) and supplementation on several aspects of menopausal health, such as fractures, vasomotor symptomatology, cardiovascular disease (CVD), cancer and infections, including coronavirus disease 2019 (COVID-19). The aim of this review is to critically summarize the evidence provided by observational studies and randomized controlled trials (RCTs) of vitamin D supplementation in postmenopausal women with VDD. Observational studies have found that VDD is associated with an increased risk of falls and fractures after the menopause. VDD also has a negative effect on menopausal symptomatology. VDD, especially its severe form, is associated with an increased risk of CVD risk factors and CVD events. VDD is associated with increased risk and mortality from several cancer types and risk of infections. The evidence from RCTs regarding the effect of vitamin D supplementation on falls, fractures, menopausal symptoms, cardiovascular disease, cancer and infections is not robust. Thus, skeletal health may benefit only when vitamin D is co-administered with calcium, especially in those ≥70 years old and with severe VDD. There is no evidence of a favorable effect on menopausal symptoms or risk of CVD or cancer, except for a modest reduction in cancer-related mortality. Inconsistency still exists regarding its effect on infection risk, disease severity and mortality due to COVID-19.

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“…Por fim, evidências sugerem a participação da vitamina D na expressão de genes do relógio circadiano central 4,25 .…”

Section: Métodounclassified

O papel da vitamina D na regulação do ciclo sono-vigília

Moreira,

Vasconcelos,

Oliveira

et al. 2023

Rev Neurocienc

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Introdução. A vitamina D exerce diversas funções no organismo, incluindo a regulação do ciclo sono-vigília, visto que sua deficiência está associada a distúrbios do sono. Entretanto, os mecanismos biológicos para esse controle não são totalmente conhecidos. Objetivo. Analisar os principais mecanismos de atuação da vitamina D na regulação do ciclo sono-vigília. Método. Revisão integrativa da literatura, realizada com pesquisa bibliográfica nas bases de dados Scielo, Pubmed e Biblioteca Virtual em Saúde, com os seguintes descritores retirados das plataformas DeCS e MeSH: “vitamin D”, “sleep”, “vitamina D” e “sono”. Foram incluídos trabalhos publicados nos últimos 5 anos e com textos completos. Resultados. Após revisão pormenorizada dos 476 resultados obtidos, foram selecionados 23 artigos para compor esta revisão. As principais hipóteses encontradas para explicar a regulação da vitamina D sobre o ciclo sono-vigília incluíram sua participação na síntese de melatonina e de neurotransmissores essenciais para as vias neurais envolvidas no ciclo sono-vigília, assim como no desenvolvimento dos neurônios que integram essas vias. Ademais, postula-se seu papel na modulação imunológica e na desintoxicação do sistema nervoso central. Conclusão. Evidencia-se a importância de compreender os possíveis mecanismos de regulação do ciclo sono-vigília pela vitamina D, principalmente pela possibilidade de explorar a fisiopatologia dos distúrbios do sono. Porém, mais estudos são necessários para esclarecer outros possíveis mecanismos de regulação.

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No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial

Cited by 9 publications

References 49 publications

Melody of sleep by sun: Association between serum vitamin D levels and sleep quality in ESRD patients.

Melody of sleep by sun: Association between serum vitamin D levels and sleep quality in ESRD patients.

Vitamin D, Menopausal Health and COVID-19: Critical Appraisal of Current Data

O papel da vitamina D na regulação do ciclo sono-vigília

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