No increased risk of Kaposi sarcoma relapse in patients with controlled HIV‐1 infection after switching protease inhibitor‐based antiretroviral therapy

Lajaunie, Rébecca; Cuzin, Lise; Palich, Romain; Makinson, Alain; Bani‐Sadr, Firouzé; Duvivier, Claudine; Arvieux, Cédric; Poizot‐Martin, Isabelle; Delpierre, Cyrille; Delobel, Pierre; Martin‐Blondel, Guillaume; Chirouze, Catherine; Drobacheff-Thiébaut, C; Foltzer, A; Bouiller, Kévin; Mathieu, Luc; Lepiller, Quentin; Bozon, F.; Babre, O; Brunel, A S; Muret, Patrice; Chevalier, Éric; Jacomet, Christine; Laurichesse, H.; Lesens, Olivier; Vidal, María Amparo Gómez; Mrozek, Natacha; Auméran, C.; Baud, Olivier; Corbin, V.; Goncalvez, E; Mirand, Audrey; Brebion, A; Henquell, Cécile; Lamaury, I.; Fabre, Isabelle; Curlier, Elodie; Ouissa, Rachida; Herrmann-Storck, Cécile; Tressières, Benoît; Receveur, M. C.; Boulard, F.; Daniel, C; Clavel, C; Roger, P.; Markowicz, Samuel; Rungen, N Chellum; Merrien, Dominique; Perre, Philippe Vande; Guimard, Thomas; Bollangier, O; Léautez, S; Morrier, Marine; Laine, L; Boucher, D; Point, P; Cotte, Laurent; Ader, Florence; Becker, Agathe; Boibieux, A.; Brochier, C.; Brunel-Dalmas, Florence; Cannesson, O.; Chiarello, Pierre; Chidiac, Christian; Degroodt, S; Ferry, Tristan; Godinot, Matthieu; Livrozet, J M; Makhloufi, Djamila; Miailhes, Patrick; Perpoint, Thomas; Perry, M.; Pouderoux, Cécile; Roux, Stanzi M le; Triffault-Fillit, Claire; Valour, Florent; Charre, Caroline; Icard, V.; Tardy, J. C.; Trabaud, Mary‐Anne; Ravaux, Isabelle; Ménard, Amélie; Belkhir, A Y; Colson, Philippe; Dhiver, Catherine; Madrid, A; Martin-Degioanni, M; Meddeb, Line; Mokhtari, M.; Motte, Anne; Raoux, Aude; Tomei, Christelle; Tissot‐Dupont, Hervé; Brégigeon, Sylvie; Zaegel-Faucher, Olivia; Obry, Vanessa; Laroche, Hélène; Orticoni, M; Soavi, M.J.; Ressiot, E.; Ducassou, M J; Jaquet, I; Galie, Sébastien; Colson, H; Ritleng, A S; Ivanova, A; Debreux, C.; Lions, C.; Rojas‐Rojas, T; Cabie, André; Abel, Sylvie; Bavay, J; Bigeard, B; Cabras, Ornella; Majoubert, R Dupin de; Fagour, Laurence; Guitteaud, K; Marquise, A; Najioullah, Fatiha; Pierre-François, Sandrine; Pasquier, Jérémie; Richard, Pierre-Yves; Rome, K; Turmel, J M; Varache, C.; Atoui, N.; Bistoquet, M; Delaporte, Éric; Moing, Vincent Le; Meftah, N; Boever, Corinne Merle De; Montès, Brigitte; Ferrer, Ana; Tuaillon, Édouard; Reynes, Jacques; Lefèvre, B; Jeanmaire, Eliette; Hénard, S.; Frentiu, E.; Charmillon, Alexandre; Legoff, Antoine; Tissot, Nadine; André, Marie; Boyer, L.; Bouillon, M P; Delestan, M; Goehringer, François; Bévilacqua, Sibylle; Rabaud, Christian; May, Thierry; Raffi, François; Allavena, Clotilde; Aubry, O; Billaud, Éric; Biron, Charlotte; Bonnet, B.; Bouchez, Sabelline; Boutoille, David; Brunet-Cartier, Cécile; Deschanvres, Colin; Gaborit, Benjamin; Grégoire, Antoine; Grégoire, Matthieu; Grossi, Olivier; Guéry, Romain; Lefèbvre, M.; Turnier, Paul Le; Lecomte, R.; Morineau, P.; Reliquet, Véronique; Sécher, S.; Cavellec, M; Paredes, Ernesto; Soria, A; Ferré, Virginie; André-Garnier, Élisabeth; Rodallec, Audrey; Puglièse, Pascal; Bréaud, S; Ceppi, C; Chirio, David; Cua, Éric; Dellamonica, P.; Demonchy, Élisa; Monte, A. De; Durant, J.; Etienne, C; Ferrando, Stephen J.; Garraffo, R.; Michelangeli, C; Mondain, V.; Naqvi, Alissa; Oran, Nazan Tuna; Perbost, I.; Carles, Marie-Josée; Klotz, Christian; Maka, A; Pradier, Christian; Prouvost-Keller, B; Risso, Karine; Rio, V; Rosenthal, Éric; Touitou, Isabelle; Wehrlen-Pugliese, S; Zouzou, G; Hocqueloux, Laurent; Prazuck, Thiérry; Gubavu, C.; Sève, Aymeric; Giachè, Susanna; Rzepecki, Vincent; Colin, M; Boulard, C.; Thomas, Gladys; Chéret, Arnaud; Goujard, Cécile; Quertainmont, Yann; Teicher, Elina; Lerolle, Nathalie; Jauréguiberry, Stéphane; Colarino, R; Deradji, O; Castro, Ángeles; Barrail-Tran, Aurélie; Yazdanpanah, Yazdan; Landman, Roland; Joly, Véronique; Ghosn, Jade; Rioux, C.; Lariven, Sylvie; Gervais, Anne; Lescure, F.-X.; Matheron, Sophie; Louni, F; Julia, Zélie; Gac, Sylvie Le; Charpentier, Charlotte; Descamps, Diane; Peytavin, Gilles; Aguilar, Claire; Alby-Laurent, Fanny; Amazzough, Karima; Benabdelmoumen, G.; Bossi, Philippe; Cessot, G; Charlier, Caroline; Consigny, Paul‐Henri; Jidar, Kaoutar; Lafont, Emmanuel; Lanternier, Fanny; Leporrier, J.; Lortholary, Olivier; Louisin, C; Lourenco, J; Parize, Perrine; Pilmis, Benoît; Rouzaud, Claire; Touam, F.; Valantin, M.A.; Tubiana, Roland; Agher, Rachid; Seang, Sophie; Schneider, Luminita; Blanc, C.; Katlama, Christine; Berger, J.; N’Guyen, Yohan; Lambert, D.; Kmiec, I; Hentzien, Maxime; Brunet, A; Romaru, Juliette; Marty, H; Brodard, Véronique; Tattevin, Pierre; Revest, M; Souala, Faouzi; Baldeyrou, M.; Patrat-Delon, Solène; Chapplain, Jean-Marc; Bénézit, François; Dupont, M; Poinot, M; Maillard, Anne; Pronier, Charlotte; Lemaître, F.; Morlat, Clément; Poisson-Vannier, M; Jovelin, T; Sinteff, J P; Gagneux‐Brunon, Amandine; Botelho-Nevers, Élisabeth; Frésard, A.; Ronat, V; Lucht, F.; Rey, David; Fischer, Patricia; Partisani, M; Cheneau, Christine; Priester, M; Batard, ML.; Mélounou, C; Bernard-Henry, Claudine; Mautort, E de; Fafi‐Kremer, Samira; Alvarez, Maria; Biezunski, N; Debard, Alexa; Delpierre, Cyrille; Gaube, Géraldine; Lansalot, P; Lelièvre, L; Marcel, M.; Piffaut, M; Porte, Lorena; Sauné, Karine; Robineau, Olivier; Ajana, F.; Aïssi, E; Alcaraz, I.; Alidjinou, Enagnon Kazali; Baclet, V.; Bocket, Laurence; Boucher, Anne; Digumber, M.; Huleux, Thomas; Lafon‐Desmurs, B.; Meybeck, Agnès; Pradier, M; Tétart, Macha; Thill, P.; Viget, N.; Valette, M.

doi:10.1111/hiv.13168

Cited by 1 publication

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“…In cohorts of KS patients that aimed to identify predictive factors of KS remission, response rate was not associated with NNRTI-based, PI-based, or boosted-PI based regimen [63,64]. Furthermore, an analysis of the prospectively collected Dat'AIDS database focusing on PLHIV with history of KS and controlled HIV replication, switching from a PI-based to a PI-free regimen was not associated with an increased risk of KS relapse [65].…”

Section: Role Of Protease Inhibitors For Treatmentmentioning

confidence: 92%

Kaposi’s Sarcoma in Virally Suppressed People Living with HIV: An Emerging Condition

Palich

Makinson

Veyri

et al. 2021

Cancers

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Since the advent of highly effective combined antiretroviral treatment (cART), and with the implementation of large HIV testing programs and universal access to cART, the burden of AIDS-related comorbidities has dramatically decreased over time. The incidence of Kaposi’s sarcoma (SK), strongly associated with HIV replication and CD4 immunosuppression, was greatly reduced. However, KS remains the most common cancer in patients living with HIV (PLHIV). HIV physicians are increasingly faced with KS in virally suppressed HIV-patients, as reflected by increasing description of case series. Though SK seem less aggressive than those in PLHIV with uncontrolled HIV-disease, some may require systemic chemotherapy. Persistent lack of specific anti-HHV-8 cellular immunity could be involved in the physiopathology of these KS. These clinical forms are a real therapeutic challenge without possible short-term improvement of anti-HHV-8 immunity, and no active replication of HIV to control. The cumulative toxicity of chemotherapies repeatedly leads to a therapeutic dead end. The introduction or maintenance of protease inhibitors in cART does not seem to have an impact on the evolution of these KS. Research programs in this emerging condition are important to consider new strategies.

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Section: Role Of Protease Inhibitors For Treatmentmentioning

confidence: 92%

Kaposi’s Sarcoma in Virally Suppressed People Living with HIV: An Emerging Condition

Palich

Makinson

Veyri

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

No increased risk of Kaposi sarcoma relapse in patients with controlled HIV‐1 infection after switching protease inhibitor‐based antiretroviral therapy

Abstract: The members of the 'And The Dat'AIDS study group' are given in the Appendix.

Cited by 1 publication

References 18 publications

Kaposi’s Sarcoma in Virally Suppressed People Living with HIV: An Emerging Condition

Kaposi’s Sarcoma in Virally Suppressed People Living with HIV: An Emerging Condition

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