2021
DOI: 10.1002/cti2.1278
|View full text |Cite
|
Sign up to set email alerts
|

No interplay between gut microbiota composition and the lipopolysaccharide‐induced innate immune response in humans in vivo

Abstract: Objective. Animal studies have demonstrated the extensive interplay between the gut microbiota and immunity. Moreover, in critically ill patients, who almost invariably suffer from a pronounced immune response, a shift in gut microbiota composition is associated with infectious complications and mortality. We examined the relationship between interindividual differences in gut microbiota composition and variation in the in vivo cytokine response induced by bacterial lipopolysaccharide (LPS). Furthermore, we ev… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 37 publications
0
2
0
Order By: Relevance
“…Instead of aiming to restore the composition of the microbiota in the acute phase of infection, researchers could focus their efforts on accelerating its restoration following ICU discharge. Although sepsis is characterized by a profoundly distorted gut microbiota, the effects of these disruptions on cytokine responses and transcriptional profiles during acute infections have been absent or modest [55,56]. These findings might allude that restoration of the microbiome in the acute phase of disease does not potentially lead to significantly altered outcomes.…”
Section: Timing Of Therapymentioning
confidence: 98%
“…Instead of aiming to restore the composition of the microbiota in the acute phase of infection, researchers could focus their efforts on accelerating its restoration following ICU discharge. Although sepsis is characterized by a profoundly distorted gut microbiota, the effects of these disruptions on cytokine responses and transcriptional profiles during acute infections have been absent or modest [55,56]. These findings might allude that restoration of the microbiome in the acute phase of disease does not potentially lead to significantly altered outcomes.…”
Section: Timing Of Therapymentioning
confidence: 98%
“…In a randomized controlled trial aiming to translate such preclinical evidence to healthy humans, gut microbiota disruption with broad-spectrum antibiotics had no effect on the surrogate markers of sepsis (e.g., vital signs and systemic cytokine responses) upon intravenous lipopolysaccharide injection [ 36 ]. Similarly, existing interindividual differences in gut microbiota composition were not associated with variation in cytokine responses (TNF-α, IL-6, IL-8 and IL-10) during the same model of experimental endotoxemia [ 37 ]. This underscores the notion that the gut microbiota is just one of the many factors that regulate the systemic immune response, and also highlights the difficulty of translating findings from animals to humans.…”
Section: Gut Microbiota In Critically Ill Patientsmentioning
confidence: 99%