No major association of A poE genotype with disease characteristics and MRI                 findings in multiple sclerosis

Zwemmer, Jack; Winsen, Lisa van; Kamp, Gerard J. van; Barkhof, Frederik; Polman, Chris H.; Uitdehaag, B. M. J.

doi:10.1191/1352458504ms1010oa

Cited by 36 publications

(27 citation statements)

References 38 publications

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“…12,15,16,18,20,22,23,25,28 Furthermore, with regard to Apo o, genetic variation was not found to be of significant importance to the age of onset, which is in agreement with previous findings. 10,15,16,18,22,23,32 The present study supports the hypothesis that the Apo o4 allele is associated with a faster disease progression in MS. A significant association was found in two subgroups, specifically in patients with disease duration of 10 years or less and in patients with RRMS. Previous studies examining the association between Apo o4 and disease progression have demonstrated contradictory results, although most studies showed an association.…”

Section: Discussionsupporting

confidence: 91%

Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis

et al. 2005

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Section: Discussionsupporting

confidence: 91%

Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis

et al. 2005

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“…The frequencies in the general population have been reported to be 10%, 74%, and 16% for ε2, ε3, and ε4, respectively (31). Owing to the fact that the E3 isoform was the most common form in various studies investigating the relationship between the general population and APOE, as well as between MS and APOE, E2 and E4 are considered variants (28,30,32,33,34,35,36,37,38,39,40,41,42,43). The prevalence of MS in Turkey is between that of the European countries in which MS is common and the Asian countries in which MS is less common.…”

Section: Discussionmentioning

confidence: 97%

Multipl Skleroz ile Apolipoprotein E Genetik Polimorfizmi Arasındaki İlişki

Taşdemir¹,

Tamam²,

Yalman³

2013

npa

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Re cei ved/Ge liş ta ri hi: 21.07.2011 Ac cep ted/Ka bul ta ri hi: 07.05.2012 © Arc hi ves of Neu ropsy chi atry, pub lis hed by Ga le nos Pub lis hing / © Nö rop si ki yat ri Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. ABS TRACTBackground: Although the etiology of multiple sclerosis (MS) has not yet been clearly elucidated, MS is a chronic inflammatory disease, in which genetic and environmental factors are involved. The association between apolipoprotein E (APOE) genetic polymorphisms and various neurodegenerative diseases, including MS, is controversial. In the current study, specific APOE genotypes were investigated in patients with MS. Methods: Fifty patients clinically diagnosed with MS and 30 healthy volunteers were included in the study. The APOE genotype was identified via the polymerase chain reaction (PCR) method. The patient and control groups were compared in terms of the frequency of APOE genotypes. Results: The APOE genotype distribution in the patient group was as follows: ε3/ε3, 82.0%; ε3/ε4, 12.0%; and ε2/ε3, 6.0%. There were no significant differences between the patient and control groups with respect to the frequency of APOE genotypes, and APOE ε4 allele carriage (p=0.56). However, the frequency of APOE ε4 allele carriers were significantly higher among male patients (p=0.007). Conclusion: These findings suggest that the APOE genotype has no effect on susceptibility to MS. Further studies with larger sample sizes to be able to include all APOE genotypes are warranted. Identification of genetic factors that may have a role in the etiology of MS will make a substantial contribution to the knowledge of the prevention and treatment of MS. (Arc hi ves of Neu ropsy chi atry 2013; 50: 110-115) Conflict of interest:The authors reported no conflict of interest related to this article. ÖZETAmaç: Multipl skleroz (MS) henüz nedeni çok iyi aydınlatılamamış olmakla birlikte genetik ve çevresel faktörlerin etkisiyle ortaya çıkan kronik inflamatuar bir hastalıktır. MS dahil çeşitli nörodejeneratif hastalıklar ile apolipoprotein E (APOE) genetik polimorfizmi arasındaki ilişki tartışmalıdır. Bu çalışmada MS'li hastalarda belirli APOE genotipleri araştırıldı. Yöntem: Klinik olarak MS tanısı almış 50 hasta ve sağlıklı 30 kişi çalışmaya alındı. APOE genotipi PCR yöntemiyle belirlendi. APOE genotiplerinin hasta ve kontrol grubunda görülme sıklıkları karşılaştırıldı. Bulgular: APOE genotip dağılımı MS grubunda sırayla ε3/ε3 %82,0, ε3/ε4 %12,0, ε2/ε3 %6,0 idi. MS ve kontrol grubu arasında genotiplerin görülme oranlarında belirgin farklılıklar yoktu ve ε4 taşıyıcılığı açısından anlamlı fark saptanmadı (p=0,56). Ancak MS hastalarında erkek cinsiyette ε4 taşıyıcılığı anlamlı olarak yüksek bulundu (p=0,007). Sonuç: Sonuçlarımız APOE genotipinin MS'a yatkınlık üzerinde etkisinin olmadığını düşündürmüştür. Daha fazla olgu ile tüm genotipleri kapsayacak şekilde geniş kapsamlı çalışmalara gerek vardır. Etiyolojide rolü olabilecek genetik faktörlerin aydınlatılması MS hastalığının önlenmesi ve te...

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“…Accordingly, we interpreted this finding as evidence for more aggressive disease, greater vulnerability to injury or impaired repair. It was also evident that differences between apoE genotypes were more marked with regard to morphologic than to [18] 2003 72 L Lower and more rapidly decreasing NAA with apoE q4 allele Enzinger C [17] 2004 99 L ApoE q4 associated with accelerated brain tissue loss and higher proportion of lesions developing into ''black holes'' Zakrzewska-Pniewska B [36] 2004 114 CS No association with lesion load and brain volume De Stefano N [40] 2004 76 CS ApoE q4 associated with lower brain volume Zwemmer JN [11] 2004 871 L No association with lesion load and brain volume CS = cross-sectional. L= longitudinal.…”

Section: Multiple Sclerosis and Apoementioning

confidence: 97%

“…These investigations commonly agree that the apoE genotype is not a risk factor for MS although some trend towards a higher frequency of the apoE q2 allele in MS patients than controls cannot be completely excluded [11]. There is also no good evidence for an association of the apoE polymorphism with a specific course of MS, i.e.…”

Section: Multiple Sclerosis and Apoementioning

confidence: 97%

The impact of our genes: Consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis

Fazekas

Enzinger

Ropele

et al. 2006

Journal of the Neurological Sciences

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No major association of A poE genotype with disease characteristics and MRI findings in multiple sclerosis

Abstract: In this cohort no association of the ApoE genotype with disease susceptibility nor clinical and MRI measures could be identified. However, combined analysis of published data could not definitely exclude the possibility of a minor role for epsilon2-carriership in MS.

Cited by 36 publications

References 38 publications

Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis

Apo E in multiple sclerosis and optic neuritis: the Apo E-o4 allele is associated with progression of multiple sclerosis

Multipl Skleroz ile Apolipoprotein E Genetik Polimorfizmi Arasındaki İlişki

The impact of our genes: Consequences of the apolipoprotein E polymorphism in Alzheimer disease and multiple sclerosis

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