No Major Impact of Skin Aging on the Response of Skin Blood Flow to a Submaximal Local Thermal Stimulus

Vionnet, Julien; Calero-Romero, Irène; Heim, Abigael; Rotaru, Corina; Engelberger, Rolf P.; Dischl, Benoît; Noël, Bernard; Liaudet, Lucas; Waeber, Bernard; Feihl, François

doi:10.1111/micc.12154

Cited by 10 publications

(5 citation statements)

References 46 publications

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“…Physiological aging is associated with an altered initial axon reflex response to local heating in the supramedial malleolar skin while the late phase is minimally affected . Similarly, there is an age dependent decrease in flare area following a six minute local heating, recorded using two‐dimensional laser imaging .…”

Section: Which Dynamic Tests Are Commonly Used?mentioning

confidence: 99%

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

2016

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Several noninvasive techniques have been developed using laser light interaction in the skin to explore the skin's microcirculation. Combined with laser Doppler or LSCI, reactivity tests are used to explore skin endothelial and neurovascular function in humans, including PORH, LTH, PIV, and iontophoresis of vasodilators. Recent advances in our comprehension of the physiological pathways underlying these reactivity tests have been possible through topical or intradermal delivery of drugs that produce elevated local concentrations. Skin microvascular function has also been proposed as a prognostic biomarker or for evaluating the effect of drugs. Comprehension of the physiological pathways, together with recent technological improvements in microcirculation imaging, has provided reliable and reproducible tools to study skin microcirculation.

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Section: Which Dynamic Tests Are Commonly Used?mentioning

confidence: 99%

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

2016

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“…During this time the second EMLA application was applied on the leg. Finally, T loc on the forearm sites was increased to 44 °C at 1 °C min −1 (2 min in total) and held at this temperature for 20 min to achieve maximal vasodilatation (Tew et al 2011a;Carter and Hodges 2011;Vionnet et al 2014;Lawley et al 2014). After this, forearm data collection sensory nerve blockade was again verified.…”

Section: Instrumentation and Experimental Proceduresmentioning

confidence: 99%

The contribution of sensory nerves to cutaneous vasodilatation of the forearm and leg to local skin heating

et al. 2015

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“…Fig. 43). Curve shows line of best fit by least squares for data recorded during postocclusive reactive hyperaemia.…”

Section: Resultsmentioning

confidence: 99%

Laser speckle contrast imaging: age-related changes in microvascular blood flow and correlation with pulse-wave velocity in healthy subjects

2014

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In the cardiovascular system, the macrocirculation and microcirculation—two subsystems—can be affected by aging. Laser speckle contrast imaging (LSCI) is an emerging noninvasive optical technique that allows the monitoring of microvascular function and can help, using specific data processing, to understand the relationship between the subsystems. Using LSCI, the goals of this study are: (i) to assess the aging effect over microvascular parameters (perfusion and moving blood cells velocity, MBCV) and macrocirculation parameters (pulse-wave velocity, PWV) and (ii) to study the relationship between these parameters. In 16 healthy subjects (20 to 62 years old), perfusion and MBCV computed from LSCI are studied in three physiological states: rest, vascular occlusion, and post-occlusive reactive hyperaemia (PORH). MBCV is computed from a model of velocity distribution. During PORH, the experimental results show a relationship between perfusion and age (R(2) = 0.67) and between MBCV and age (R(2) = 0.72), as well as between PWV and age at rest (R(2) = 0.91). A relationship is also found between perfusion and MBCV for all physiological states (R(2) = 0.98). Relationships between microcirculation and macrocirculation (perfusion-PWV or MBCV-PWV) are found only during PORH with R(2) = 0.76 and R(2) = 0.77, respectively. This approach may prove useful for investigating dysregulation in blood flow.

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No Major Impact of Skin Aging on the Response of Skin Blood Flow to a Submaximal Local Thermal Stimulus

Abstract: Skin aging, whether intrinsic or combined with photoaging, reduces the maximal vasodilatory capacity of the dermal microcirculation, but not its reactivity to local heating.

Cited by 10 publications

References 46 publications

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

The contribution of sensory nerves to cutaneous vasodilatation of the forearm and leg to local skin heating

Laser speckle contrast imaging: age-related changes in microvascular blood flow and correlation with pulse-wave velocity in healthy subjects

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