No Microalbuminuria or Other Adverse Effects of Long-Standing Hyperfiltration in Humans With One Kidney

Schmitz, A.; Christensen, Cramer; Christensen, T.; Sølling, K

doi:10.1016/s0272-6386(89)80131-3

Cited by 43 publications

(24 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This theory is supported by reports showing that in adult patients with URA, there is a higher prevalence of albuminuria, proteinuria, hypertension, and renal insufficiency than in the normal population and that these abnormalities are more frequent after a longer follow-up period [24][25][26][27][28] . However, it has to be mentioned that other studies could demonstrate that adults with a solitary kidney since childhood had no adverse effects of longstanding hyperfiltration [29,30] . Therefore, there is still some controversy that needs large long-term studies for more than 3 decades to solve this issue definitely.…”

Section: Discussionmentioning

confidence: 99%

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Seeman

Patzer

John

et al. 2006

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aim: Unilateral renal agenesis (URA) is a model for a reduced nephron number that is believed to be a risk factor for blood pressure (BP) elevation and reduced renal function. The aim of the study was to investigate BP and renal function in children with URA. Methods: Data on children with URA from two pediatric nephrology centers were firstly retrospectively reviewed (renal ultrasound and scintigraphy, clinical BP, creatinine clearance, urinalysis). Children with normal renal ultrasound and scintigraphy were thereafter investigated using ambulatory BP monitoring. Results: Twenty-nine children with URA were investigated – 14 children with an abnormal kidney (mostly scarring) and 15 children with healthy kidneys. Hypertension was diagnosed on the basis of clinical BP in 57% of the children with abnormal kidneys and on the basis of ambulatory BP monitoring in 1 child (7%) with healthy kidneys. The mean ambulatory BP in children with normal kidneys was not significantly different from that in controls. Forty-three percent of the children with abnormal kidneys had a reduced renal function, but none of children with normal kidneys. Conclusions: Children with abnormalities of a solitary kidney have often hypertension, proteinuria, or a reduced renal function. In contrast, children with healthy solitary kidneys have BP and renal function similar to those of healthy children.

show abstract

Section: Discussionmentioning

confidence: 99%

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Seeman

Patzer

John

et al. 2006

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…It leads to compensatory renal growth [296,326] and an increased risk of hypertension and kidney failure in adulthood with low GFR, elevated urinary protein excretion and sclerosing glomerular lesions [301,310,314,[327][328][329][330][331][332] , even though not all studies show this [322] . In a cohort of 66 patients with congenital solitary kidneys, we have shown that 50% of these children are hypertensive, using antihypertensive drugs, or have microalbuminuria at a mean age of 9 years [Schreuder et al, unpubl.…”

Section: Renal Mass Reduction In Menmentioning

confidence: 99%

Consequences of Intrauterine Growth Restriction for the Kidney

Schreuder

Waal

Wijk

2006

Kidney Blood Press Res

View full text Add to dashboard Cite

Low birth weight due to intrauterine growth restriction is associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage renal disease. The purpose of this review is to describe the effects of intrauterine growth restriction on the kidney. Nephrogenesis requires a fine balance of many factors that can be disturbed by intrauterine growth restriction, leading to a low nephron endowment. The compensatory hyperfiltration in the remaining nephrons results in glomerular and systemic hypertension. Hyperfiltration is attributed to several factors, including the renin-angiotensin system (RAS), insulin-like growth factor (IGF-I) and nitric oxide. Data from human and animal studies are presented, and suggest a faltering IGF-I and an inhibited RAS in intrauterine growth restriction. Hyperfiltration makes the kidney more vulnerable during additional kidney disease, and is associated with glomerular damage and kidney failure in the long run. Animal studies have provided a possible therapy with blockage of the RAS at an early stage in order to prevent the compensatory glomerular hyperfiltration, but this is far from being applicable to humans. Research is needed to further unravel the effect of intrauterine growth restriction on the kidney.

show abstract

“…Some authors have also measured renal volume after unilateral nephrectomy and indicate that a hypertrophy of 86% occurred. 8 Two other studies 20,21 have measured renal size after unilateral nephrectomy with ultrasound using different methods from ours, and a mean hypertrophy of 100% was found. 20 However, the populations studied in these two works 8,20 differ significantly in factors such as age and time since nephrectomy from ours, so that these studies and ours may not be comparable.…”

mentioning

confidence: 70%

Image-directed color Doppler ultrasound evaluation of the single kidney after unilateral nephrectomy in adults

Gómez‐Anson¹,

Carrero-López²,

Díaz-González³

1997

J. Clin. Ultrasound

View full text Add to dashboard Cite

No Microalbuminuria or Other Adverse Effects of Long-Standing Hyperfiltration in Humans With One Kidney

Cited by 43 publications

References 31 publications

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Blood Pressure, Renal Function, and Proteinuria in Children with Unilateral Renal Agenesis

Consequences of Intrauterine Growth Restriction for the Kidney

Image-directed color Doppler ultrasound evaluation of the single kidney after unilateral nephrectomy in adults

Contact Info

Product

Resources

About