NO news: S-(de)nitrosylation of cathepsins and their relationship with cancer

Bhattacharyya, Camelia; Chakraborty, Surupa; Sengupta, Rajib

doi:10.1016/j.ab.2022.114872

Cited by 3 publications

(2 citation statements)

References 191 publications

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“…At the same time, the effectiveness of the thioredoxin system is of particular importance in the detoxification of harmful metabolites such as lipid peroxides, as well as in the regulation of gene expression and modulation of cellular signaling pathways [ 106 , 107 ]. An equally important function of this system is the regulation of the expression of many proteins, including apoptosis-regulating kinase (ASK-1) [ 77 , 108 ], and since it has been shown that the Trx-dependent system may contribute to both the intensification of angiogenesis and cell apoptosis, they have important regenerative role compounds that prevent excessive activation of the Trx-dependent system, including polyphenol compounds that inactivate elements of the thioredoxin system [ 109 , 110 ], which are also components of algae.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts

Stasiewicz,

Conde,

Domingues

et al. 2024

Antioxidants

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UVA radiation leads to oxidative stress and inflammation in skin cells. Therefore, the aim of this study was to compare the effect of lipid extracts from microalgae Nannochloropsis oceanica (N.o.) (marine) and Chlorococcum amblystomatis (C.a.) (freshwater) on the redox balance and PUFA metabolism in human skin fibroblasts modified by UVA. Lipid extracts from both types of microalgae introduced into the fibroblast medium after UVA irradiation significantly reduced the level of ROS and enhanced expression of Nrf2, which increased the activity/level of antioxidants (SOD1/2, CAT, GSH, Trx). The reduction in oxidative stress was accompanied by a decrease in the level of 4-HNE, its protein adducts and protein carbonyl groups. Microalgae also reduced the activity of COX1/2, FAAH and MAGL increased by UVA, and as a consequence, the level of lipid mediators (especially after N.o.) decreased, both from the group of endocannabinoids (AEA, 2-AG, PEA) and eicosanoids (PGE2, 15d-PGJ2, TXB2, 15-HETE), acting mainly through receptors related to G protein, the expression of which increases after UVA. This further contributed to the reduction in oxidative stress and pro-inflammatory signaling at NF-κB and TNFα levels. Therefore, it is suggested that lipid extracts from both N.o. and C.a. microalgae can be used to regenerate fibroblast metabolism disturbed by UVA radiation.

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Section: Discussionmentioning

confidence: 99%

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts

Stasiewicz,

Conde,

Domingues

et al. 2024

Antioxidants

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show abstract

“…Many NO donor drugs, such as nitroglycerin, sodium nitroprusside, nicorandil, Bidil, etc., have been widely used in the clinic to treat angina, heart failure, and other cardiovascular diseases [14]. The accumulated findings show that S-nitrosylation of cathepsins under the influence of NO-donors can prevent invasion of cancer and cause cancer cell death by blocking the activity of cathepsins as well as the major denitrosylase systems using a multi-way approach [126]. In summary, regulating the levels of the proteins of S-nitrosylation by changing the levels of NO may treat some related diseases.…”

Section: Challenges and Limitationsmentioning

confidence: 99%

The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements

Wu,

Li,

et al. 2024

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<p class="MsoNormal" style="text-align: justify;"><span lang="EN-US" style="font-family: Nunito; color: #212529; background: white;">Protein S-nitrosylation (SNO), emerging as an important posttranslational modification, involves covalent addition of nitric oxide (NO) to the sulfur atom of cysteine in proteins. Accumulated evidence suggests that protein SNO plays crucial roles in pathophysiological mechanisms in cancer, which is attracting great attention. However, there are still controversies about whether S-nitrosylated proteins act as oncogenic proteins or tumor suppressors in cancer. In this review, we provide an overview of the early and latest evidence regarding the underlying mechanism and dual roles of SNO in cancer, in an effort to clarify its contribution in tumor progression. It has been well established that S-nitrosylated proteins restrain tumor progression in several types of cancer, while they have exhibited activities in promoting cell proliferation and inhibiting apoptosis in some other kinds of cancer. Interestingly, emerging evidence also has highlighted both its anti-cancer and pro-tumorigenic roles in several other cancer diseases. Finally, current limitations and future research prospects are presented. The overview of targeting SNO in cancer will provide new opportunities for drug development through in-depth exploration of SNO-mediated signaling pathways.</span></p>

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S-(de)-Nitrosylation of Caspases: The Achilles Heel in the Expanding Sea of Cancer Treatment Regimens

Chakraborty,

Choudhuri,

Mishra

et al. 2024

Interdisciplinary Cancer Research

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NO news: S-(de)nitrosylation of cathepsins and their relationship with cancer

Cited by 3 publications

References 191 publications

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts

Comparison of the Regenerative Metabolic Efficiency of Lipid Extracts from Microalgae Nannochloropsis oceanica and Chlorococcum amblystomatis on Fibroblasts

The Dual Roles of S-Nitrosylation of Proteins in Cancer: Molecular Mechanisms and Recent Advancements

S-(de)-Nitrosylation of Caspases: The Achilles Heel in the Expanding Sea of Cancer Treatment Regimens

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