No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

Peerbooms, Joost C; Colaris, Joost W.; Hakkert, Anita A.; Appeldorn, Mark Van; Bruijn, Daniël J; Oudsten, Brenda L. Den; Gosens, Taco

doi:10.1007/s00264-012-1603-9

Cited by 34 publications

(35 citation statements)

References 21 publications

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“…Results with the application of PRP together with allograft or autograft in surgical treatment have been varied. Some researchers have maintained that PRP has positive effects, while others have claimed that there is no benefit of PRP [51,52].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Atrophic Non-Union Fracture Healing Using Autologous Progenitor Cell-Rich Bone Marrow

Venkatesh¹

2016

SRDT

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There is growing interest in the use of bone marrow derived stem cells for bone repair. Increasing evidence now indicates that physiological bone remodelling occurs in close proximity to blood vessels and that these vessels carry perivascular stem cells that differentiate into osteoblasts. Non-union of bones are serious complication, incidences of which can be as high as 5% to 20%, varies by fracture site and is influenced by a number of fracture characteristics and host factors. The healing of fractures is a complex physiological process which could be interrupted by various factors. Thus, development of a novel therapeutic method to treat non-union fractures' becomes a clinical necessity. The purpose of this study was to assess the safety and efficacy of the autologous bone marrow concentrate preconditioned with synthetic graft in the treatment of non-union bone fractures. Autologous Bone Marrow Concentrate (aBMC) was prepared from bone marrow aspirate utilizing rapid, intraoperative point-of-care system via a density gradient centrifugation. A total of 17 patients were treated with aBMC at the fracture site and evaluated for the length of bone fracture healing time during the study follow-up period. The mean Total Nucleated Cell Count (TNCC) and Mononuclear Cell Count (MNCC) in all the patients were 5.54 x 10 8 ± 1.99 and 1.64 x 10 8 ± 0.86, respectively. 82% of the patients showed considerable bone healing of the non-union and the mean time for bone union/healing was 6 months. Overall the study concludes aBMC administration to be safe and effective in treating patients with atrophic non-unions and may contribute as an alternative to autologous cancellous bone graft.

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Section: Discussionmentioning

confidence: 99%

Enhancement of Atrophic Non-Union Fracture Healing Using Autologous Progenitor Cell-Rich Bone Marrow

Venkatesh¹

2016

SRDT

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“…39 PRP is safe, but effectiveness remains to be unquestionably proven. Clinical studies have shown variable results, 2,16,18,28,30 and basic science and animal studies range from positive outcomes 11,20,25,35 to suggesting little benefit for some types of injury. For example, a recent article by Delos et al 8 showed no benefit of using PRP in an animal model of contusion injury.…”

Section: Discussionmentioning

confidence: 99%

Site-specific Targeting Platelet-rich Plasma Via Superparamagnetic Nanoparticles

Lovering¹,

Vanegas²,

Pratt³

et al. 2014

Medicine & Science in Sports & Exercise

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Background: Muscle strains are one of the most common injuries treated by physicians. Standard conservative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus regarding treatments to accelerate recovery. Recently, clinical use of platelet-rich plasma (PRP) has gained momentum as an option for therapy and is appealing for many reasons, most notably because it provides growth factors in physiological proportions and it is autologous, safe, easily accessible, and potentially beneficial. Local delivery of PRP to injured muscles can hasten recovery of function. However, specific targeting of PRP to sites of tissue damage in vivo is a major challenge that can limit its efficacy.

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“…It contains multiple growth factors, including transforming growth factor, insulin-like growth factor, fibroblast growth factor, and platelet derived growth factor and because of these it has been shown to have positive effects on stimulation of bones, blood vessels, and the formation of chondrocytes [2]. Femoral neck fractures are one of the greatest challenges facing nearly all orthopaedic surgeons with medical and economic burden.…”

Section: Introductionmentioning

confidence: 99%

The role of platelet rich plasma in management of fracture neck femur: new insights

Samy

2015

International Orthopaedics (SICOT)

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No positive bone healing after using platelet rich plasma in a skeletal defect. An observational prospective cohort study

Cited by 34 publications

References 21 publications

Enhancement of Atrophic Non-Union Fracture Healing Using Autologous Progenitor Cell-Rich Bone Marrow

Enhancement of Atrophic Non-Union Fracture Healing Using Autologous Progenitor Cell-Rich Bone Marrow

Site-specific Targeting Platelet-rich Plasma Via Superparamagnetic Nanoparticles

The role of platelet rich plasma in management of fracture neck femur: new insights

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