No Proof that Biofilm Bacteria are Causing Dermal Filler Granulomas

Lemperle, Gottfried

doi:10.34297/ajbsr.2019.04.000749

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…However, impurities, residual proteins and nucleic acid fragments leading to immune reactions may still exist after purification (31,32,91). It is unclear whether the few cases of angioedema and granulomas were due to impurities in the used HA products or by the possible contamination of the needle with bacteria used to puncture the skin (92)(93)(94). But a recent systematic review investigated the incidence of delayed inflammatory reactions associated with HA injection (17).…”

Section: Summary Of Evidencementioning

confidence: 99%

Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis

et al. 2021

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Introduction: The lips and the mouth play an indispensable role in vocalization, mastication and face aesthetics. Various noxious factors may alter and destruct the original structure, and appearance of the lips and the anatomical area surrounding the mouth. The application of hyaluronic acid (HA) may serve as a safe method for lip regeneration. Although a number of studies exist for HA effectiveness and safety, its beneficial effect is not well-established.Aim: The present meta-analysis and systematic review was performed to investigate the effectiveness of HA on lip augmentation. We also investigated the types and nature of adverse effects (AEs) of HA application.Methods: We reported our meta-analysis in accordance with the PRISMA Statement. PROSPERO protocol registration: CRD42018102899. We performed the systematic literature search in CENTRAL, Embase, and MEDLINE. Randomized controlled trials, cohort studies, case series and case reports were included. The untransformed proportion (random-effects, DerSimonian-Laird method) of responder rate to HA injection was calculated. For treatment related AEs descriptive statistics were used.Results: The systematic literature search yielded 32 eligible records for descriptive statistics and 10 records for quantitative synthesis. The results indicated that the overall estimate of responders (percentage of subjects with increased lip fullness by one point or higher) was 91% (ES = 0.91, 95% CI:0.85−0.96) 2 months after injection. The rate of responders was 74% (ES = 0.74, 95% CI:0.66−0.82) and 46% (ES = 0.46, 95% CI:0.28−0.65) after 6 and 12 months, respectively. We included 1,496 participants for estimating the event rates of AEs. The most frequent treatment-related AEs were tenderness (88.8%), injection site swelling (74.3%) and bruising (39.5%). Rare AEs included foreign body granulomas (0.6%), herpes labialis (0.6%) and angioedema (0.3%).Conclusion: Our meta-analysis revealed that lip augmentation with injectable HA is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. Moreover, we found that most AEs of HA treatment were mild or moderate, but a small number of serious adverse effects were also found. In conclusion, further well-designed RCTs are still needed to make the presently available evidence stronger.

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Section: Summary Of Evidencementioning

confidence: 99%

Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis

et al. 2021

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Non-ischemic complications of dermal fillers

Mehta¹,

Li²,

Woodward³

et al. 2023

Plast Aesthet Res

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Dermal fillers have been commonly used for the filling of facial rhytids. As the use of dermal fillers has grown, so has the incidence of non-ischemic complications. These complications range from edema, bruising, and erythema to more complex conditions such as delayed hypersensitivity nodules and biofilms. This article sought to review the causes of various non-ischemic complications, discuss their risk factors, and review management techniques. Certain predisposing factors to delayed hypersensitivity nodules, such as Vycross technology, a history of viral illness, or coronavirus disease 19 (COVID-19) infections, are discussed in detail in this review. Prevention techniques such as patient counseling, elucidating certain patient history (viral illness, dental procedures), the use of aseptic technique, and procedural factors are also discussed. Understanding appropriate management for these complications can also help in treatment. Imaging, such as ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI), has taken on a larger role in the management of non-ischemic complications.

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No Proof that Biofilm Bacteria are Causing Dermal Filler Granulomas

Abstract: This work is licensed under Creative Commons Attribution 4.0 License AJBSR.MS.ID.000749

Cited by 2 publications

References 21 publications

Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis

Hyaluronic Acid Is an Effective Dermal Filler for Lip Augmentation: A Meta-Analysis

Non-ischemic complications of dermal fillers

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