No protective benefits of low dose acute L-glutamine supplementation on small intestinal permeability, epithelial injury and bacterial translocation biomarkers in response to subclinical exertional-heat stress: A randomized cross-over trial

Ogden, Henry B; Fallowfield, Joanne L.; Child, Robert B.; Davison, Glen; Fleming, Simon; Delves, Simon K.; Millyard, Alison; Westwood, Caroline; Layden, Joseph D.

doi:10.1080/23328940.2021.2015227

Cited by 3 publications

(3 citation statements)

References 72 publications

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“…• ↓ Intestinal permeability (Butler-Dawson et al, 2019;Gan et al, 2022;King et al, 2016) • ↓ Cytokinaemia (Bouchama et al, 2022;Ogden et al, 2021) • ↑ Leukocyte function (Bouchama et al, 2022) • ↑ Central drive and ↓ perceived effort may increase EHS risk (Carter et al, 2007) • Large doses may induce GI symptoms (Dong et al, (Roberts et al, 2021;Zuhl et al, 2015;Zuhl et al, 2014) • Higher doses may induce GI symptoms (Parker et al, 2018) • No beneficial effect at low doses (Peel et al, 2021;Roberts et al, 2021) Bovine colostrum 20 g day −1 for 14 days…”

Section: Potential Mechanisms Of Protection Against Ehs Considerationsmentioning

confidence: 99%

“…• ↑ Intracellular HSP70 (Zuhl et al, 2014(Zuhl et al, , 2015 • ↓ Intestinal permeability (Pugh et al, 2017;Zuhl et al, 2014Zuhl et al, , 2015 • Higher doses may induce GI symptoms (Ogden et al, 2020) • No beneficial effect at low doses (Ogden et al, 2021;Pugh et al, 2017) Bovine colostrum 20 g day −1 for 14 days (Barwood et al, 2020) 0.1−0.5 g l −1 • ↓ Thermal sensation may increase the risk of exceeding safe T c levels Dietary nitrate (beetroot) (Maughan et al, 2018) 200-300 mg before exercise or for >3 days…”

Section: Hydrationmentioning

confidence: 99%

“…However, this supplementation strategy is poorly tolerated in some individuals (Ogden et al., 2020 ). Lowering the glutamine dose to ≤0.3 g kg −1 improves tolerance, but has no meaningful protective effects (Ogden et al., 2021 ; Pugh et al., 2017 ). Available data do not indicate any influence of glutamine supplementation on T c elevation during aerobic exercise in humans (Ogden et al., 2021 ; Pugh et al., 2017 ; Zuhl et al., 2014 ).…”

Section: Nutrition and Ehs Riskmentioning

confidence: 99%

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Exertional heat stroke: nutritional considerations

Lee

Tan

Ogden

et al. 2022

Experimental Physiology

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Exertional heat stroke (EHS) is a life-threatening illness and an enduring problem among athletes, military servicemen and -women, and occupational labourers who regularly perform strenuous activity, often under hot and humid conditions or when wearing personal protective equipment. Risk factors for EHS and mitigation strategies have generally focused on the environment, health status, clothing, heat acclimatization and aerobic conditioning, but the potential role of nutrition is largely underexplored. Various nutritional and dietary strategies have shown beneficial effects on exercise performance and health and are widely used by athletes and other physically active populations. There is also evidence that some of these practices may dampen the pathophysiological features of EHS, suggesting possible protection or abatement of injury severity. Promising candidates include carbohydrate ingestion, appropriate fluid intake and glutamine supplementation. Conversely, some nutritional factors and low energy availability may facilitate the development of EHS, and individuals should be cognizant of these. Therefore, the aims of this review are to present an overview of EHS along with its mechanisms and pathophysiology, discuss how selected nutritional considerations may influence EHS risk focusing on their impactThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Potential Mechanisms Of Protection Against Ehs Considerationsmentioning

confidence: 99%

Section: Hydrationmentioning

confidence: 99%

Section: Nutrition and Ehs Riskmentioning

confidence: 99%

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Exertional heat stroke: nutritional considerations

Lee

Tan

Ogden

et al. 2022

Experimental Physiology

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Nutritional Considerations in Exercise-Based Heat Acclimation: A Narrative Review

Rosbrook,

Margolis,

Pryor

2024

Sports Med

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Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat‐Related Illness

Zuhl,

Specht,

Beatty

et al. 2024

Journal of Nutrition and Metabolism

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A rise in body temperature caused by physical work, including exercise, in a hot climate can lead to heat‐related illnesses such as exertional heat exhaustion and stroke. Individuals who work physically demanding occupations in hot environments are at heightened risk of heat injury. The mechanisms that contribute to heat illness resulting from physical work in the heat are complex and include dehydration, tissue ischemia and damage, oxidative stress, and inflammatory events. Therefore, it is important to develop strategies that address these mechanistic underpinnings to prevent exacerbation to heat illness. Glutamine is an amino acid that has been considered conditionally essential during situations of biological stress (e.g., tissue burn, exercise, sepsis) due to high rates of tissue consumption. Evidence suggests that glutamine may serve as an important nutrient during heat stress and when combined with other preventative measures (e.g., cooling techniques, work/rest ratios, clothing) may help to mitigate heat illness among individuals working in extreme climates. The aim of this review is to examine the current literature on the role of glutamine during heat stress.

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No protective benefits of low dose acute L-glutamine supplementation on small intestinal permeability, epithelial injury and bacterial translocation biomarkers in response to subclinical exertional-heat stress: A randomized cross-over trial

Cited by 3 publications

References 72 publications

Exertional heat stroke: nutritional considerations

Exertional heat stroke: nutritional considerations

Nutritional Considerations in Exercise-Based Heat Acclimation: A Narrative Review

Glutamine Supplementation: A Possible Strategy to Help Mitigate Health Risks of Heat‐Related Illness

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