No-reflow phenomenon in the cerebral circulation of the gerbil.

Clot Fragments Formed from Original Thrombus Obstruct Downstream Arteries in the Ischemic Injured Brain

“…When the period of ischemia increased, the numbers and extent of perfusion deficits also increased. No‐reflow was also observed later by several other groups with different stroke models [5, 13, 16, 20 ].…”

Critical cerebral blood flow for production of hemiparesis after unilateral carotid occlusion in the gerbil.

“…The studies of Levy et al (1975) andHarrison et al (1975) have also indicated that impaired re-perfusion (no-reflow) is uncommon in this experimental model.…”

“…In addition, observations were made on the recovery of rCBF after removal of unilateral CCA occlusion. Levy et al (1975) and Harrison et al (1975), using techniques other than flow measurements, showed no evidence of postischaemic poor perfusion (no-reflow) after transient ischaemia in this model. Post-occlusive measurement of rCBF was, therefore, performed in the present experiments to confirm these observations.…”

Cerebral blood flow and metabolism in man following cardiac arrest.

“…Those who advise against their use claim an increased incidence of intracranial hemorrhage as a major complication of this therapy. While intracranial hemorrhage is a recognized complication of subacute bacterial endocarditis, 4 information linking this complication to the use of anticoagulants is largely based on case reports of few patients. 67 In order to study the effect of anticoagulants during septic cerebral embolization, we administered anticoagulants to dogs while embolization was carried out, using a technique originally developed by Molinari.…”