No significant effect on bone mineral density by high doses of vitamin D3 given to overweight subjects for one year

Abstract

BackgroundIn meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects.MethodsThe study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 completed the study. The subjects were randomized to vitamin D3 40.000 IU per week (DD group), vitamin D3 20.000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily. Serum 25(OH)D, osteoprotegrin (OPG), receptoractivator of nuclear factor-kappaB ligand (RANKL), and BMD at the lumbar spine and the hip were measured before and at the end of the study.ResultsAt baseline the mean serum 25(OH)D levels were 58 nmol/L (all subjects) and increased to 141 and 100 nmol/L in the DD and DP groups, respectively. After one year, no significant differences were found between the three groups regarding change in BMD, serum OPG or RANKL.ConclusionsSupplementation with high doses of vitamin D for one year does not appear to have a negative effect on BMD in healthy subjects. In order to disclose a positive effect, subjects with low BMD and/or low serum 25(OH)D levels need to be studied.Trial registrationThe trial was registered at ClinicalTrials.gov (NCT00243256).

The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels

“…If this window is narrow, tailoring of supplementation will be of great importance and dose adjustments have to be made. However, it is more likely that the window is rather wide as it has been difficult to show a clinical effect of increasing the serum 25(OH)D level from 50-70 nmol/l to close to 150 nmol/l (18,19,20,34,35,36 This study has some weaknesses. We pooled data from three different studies, and due to different study profiles, some heterogeneity would be expected, and only for the bone density study had we more than one measurement after starting the vitamin D supplementation.…”

Bone health in healthy Indian population aged 50 years and above

“…Data from other studies has been inconsistent, with some crosssectional studies unable to demonstrate any correlation between calcium and vitamin D supplementation and BMD [34,35], while others are reporting a positive correlation [36,37]. Similarly, BMD at all sites was no different among those with or without history of fracture, in both sexes and different age groups.…”

Estimation of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish smoker rheumatoid arthritis consumers

“…There is some evidence for a role of Cu deficiency in age-related osteroporosis. Serum copper levels of 46 elderly patients with fractures of the femoral neck were reported to be significantly lower than those of a group of controls matched for age and sex (Jorde et al 2010). A significant positive correlation between serum Cu concentration and bone mineral density at the lumbar spine has been reported in a cross-sectional study in postmenopausal women (Conlan et al 1990).…”