No Smoke Without Fire: Should We Be More Concerned About the Association Between Smoking and dementia?

Chen, Ruoling; Orton, Sophie

doi:10.2217/nmt.12.46

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“…There is evidence that active smoking significantly increases the risk of cognitive impairment and dementia in older adults. 1 –3 As passive smoking has been reported to be a risk factor for many serious health morbidities similar to those associated with active smoking, 4 it is reasonable to assume that a link between passive smoking and cognitive impairment and dementia may also exist. In particular, passive smoking has been shown to be a risk factor for cardiovascular disease and pulmonary function impairment, 5 –7 which in turn are known risk factors for some types of dementia 8 and cognitive impairment.…”

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confidence: 99%

Association of Passive Smoking With Cognitive Impairment in Nonsmoking Older Adults

Chen

Zhi

Orton

et al. 2013

J Geriatr Psychiatry Neurol

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Association of passive smoking with cognitive impairment in older adults is unclear. We carried out a systematic literature review and a new study to determine the association. There were 3 cross-sectional studies published, showing a significant association of passive smoking with cognitive impairment (a relative risk (RR) of about 1.30-1.90). In the new cohort study, we interviewed 1081 never-smoking participants aged ≥ 65 years in China using a standard method of the Geriatric Mental State-Automated Geriatric Examination for Computer Assisted Taxonomy and found a significant association with dose response; multivariate adjusted RR was 1.02 (95% confidence interval 0.67-1.55) in > 0 to 49 exposure level years of passive smoking, 1.57 (1.00-2.47) in 50 to 99, and 2.12 (1.24-3.63) in ≥ 100, trend P = .008. The relationship seems not to be a reverse causality of the effect. Passive smoking could be considered an important risk factor for cognitive impairment in older adults. Avoiding exposure to passive smoking would help to preserve cognitive decline in later life.

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