No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer

Hayashi, Naoki; Egami, Hiroshi; Kai, Makoto; Kurusu, Yuji; Takano, Sadamu; Ogawa, Michio

doi:10.1016/s0039-6060(99)70003-6

Cited by 116 publications

(48 citation statements)

References 19 publications

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“…Ozawa (10) described the anterior transection technique in 1990. This technique was popularized over the next decade (11)(12)(13)(14)(15), driven by the perceived disadvantages of conventional right liver mobilization, namely impaired hepatic blood flow with rotational displacement of the liver (10), potential avulsion of hepatic veins (13), iatrogenic tumour rupture (13,16), and hematogenous dissemination of malignant cells when the hepatic veins remained patent (16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

Modified hanging manoeuvre facilitates inferior vena cava resection and reconstruction during extended right hepatectomy: A technical case report

Cawich

Thomas

Ragoonanan

et al. 2017

Molecular and Clinical Oncology

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Abstract. Liver resections are safe when performed by specialized hepatobiliary teams. However, complex liver resections are accompanied by significant perioperative risk and they may require modifications of the conventional surgical techniques. We herein report the case of a 54-year-old male patient who underwent an extended right liver resection with en bloc resection and reconstruction of the inferior vena cava. For this complex resection, a modification of the standard operative technique was required. A modified hanging manoeuvre was performed using two 19Fr nasogastric tubes outside the traditional avascular plane to facilitate resection. This modification of the hanging manoeuvre was proven to be feasible and safe, and it is recommended for inclusion in the armamentarium of hepatobiliary surgeons when complex resections are required.

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Section: Discussionmentioning

confidence: 99%

Modified hanging manoeuvre facilitates inferior vena cava resection and reconstruction during extended right hepatectomy: A technical case report

Cawich

Thomas

Ragoonanan

et al. 2017

Molecular and Clinical Oncology

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“…One explanation might be that hepatic metastasis is a major cause of failure after surgery for colorectal cancer. Because during surgery, tumor cells could disseminate from cutting points of blood vessels to intestinal canal or lymphatic vessels, and surgical compression could push cancer cell to reach portal vein system through mesenteric vessels and then invade the liver, causing liver metastasis (Hayashi et al, 1999). It is reported that plenty of portal venous blood supply for metastatic hepatic carcinoma via percataneous hepatic portography, especially at a port where tumor developed fast (Hayashi et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Because during surgery, tumor cells could disseminate from cutting points of blood vessels to intestinal canal or lymphatic vessels, and surgical compression could push cancer cell to reach portal vein system through mesenteric vessels and then invade the liver, causing liver metastasis (Hayashi et al, 1999). It is reported that plenty of portal venous blood supply for metastatic hepatic carcinoma via percataneous hepatic portography, especially at a port where tumor developed fast (Hayashi et al, 1999). Therefore, it is hypothesized that blood supply from portal vein could play an important role in maintaining tumor growth, and chemotherapy via the portal vein should have great therapeutic value in treating liver metastasis from colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer

Liu²,

Huang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the effect of portal vein chemotherapy on liver metastasis after surgical resection of colorectal cancer. Methods: Patients fulfilling the eligibility criteria were assigned to receive either surgery plus 1-week continuous infusion of 5-FU (study group) or surgery alone (observational group). Patients in the study group received portal vein chemotherapy, whereby 5-FU (1000 mg/d) and heparin (5000 IU/d) infusion was initiated from the day of surgery and lasted for 7 consecutive days. Liver metastasis was monitored during five years follow-up postoperatively. Results: Sixty four patients were recruited and assigned to the study group (12 with colon and 20 with rectal cancer) or the control group (10 with colon and 22 with rectal cancer). Liver metastasis rate was 12.5% in study and 25.0% in observational group, the difference being significant (P<0.01). Conclusion: Portal vein chemotherapy could be an effective treatment in preventing liver metastasis after surgical resection of colorectal cancer.

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“…Warr RP obtained blood samples at 2 different sessions and 24 hours postoperatively in those with malignant melanoma [10] . According to Hayashi N, the blood samples were obtained through a catheter in the portal vein before, during, and after manipulation of colorectal cancer [40] . Lemonie obtained peripheral blood samples at two different intervals: the first, during the exploratory phase and the second, after hepatectomy was completed [41] .…”

Section: Discussionmentioning

confidence: 99%

Does surgical resection of hepatocellular carcinoma accelerate cancer dissemination?

Sheen

Jeng²,

Shih³

et al. 2004

WJG

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AIM:This study was to investigate whether surgery could increase cancer dissemination and postoperative recurrence in patients with hepatocellular carcinoma (HCC) by detection of human α-fetoprotein messenger RNA (hAFP mRNA). hAFP mRNA in the peripheral blood of patients with HCC has been considered as a surrogate marker for circulating tumor cells. METHODS:Eighty-one consecutive patients who underwent curative resection for HCC entered this prospective cohort study. We examined hAFP mRNA from the peripheral blood obtained preoperatively, perioperatively, and postoperatively to correlate the prognosis after curative resections from HCC patients and from the control subjects. Detection of hAFP mRNA by reverse transcriptase and polymerase chain reaction amplification (RT-PCR) was performed with primers specifically. The relations between the clinical variables (age, sex, associated liver cirrhosis, hepatitis B virus infection, hepatitis C virus infection, serum α-fetoprotein and ChildPugh class), the histological variables (size, capsule, vascular permeation, grade of differentiation, and daughter nodules), hAFP mRNA in peripheral blood of 3 different sessions, and postoperative course (recurrence, and recurrence related death) were analysed. RESULTS:No hAFP mRNA was detected in control group subjects. Twenty-two (27%), 24 (30%) and 19 (23%) of 81 HCC patients had hAFP mRNA positivity in the preoperative, perioperative and postoperative peripheral blood. The preoperative presence did not influence the risk of HCC recurrence (55% vs 41%, P=0.280). In contrast, patients with postoperative presence had a significantly higher recurrence (90% vs 31%, P<0.001; odds ratio 19.2; 95% confidence interval: 4.0-91.7). In the multivariate analysis by COX proportional hazards model, postoperative positivity had a significant influence on recurrence (P=0.067) and recurrence related mortality (P=0.017). Whereas, the perioperative positivity of hAFP mRNA did not increase HCC recurrence (58% vs.39%, P=0.093). The correlation between perioperative hAFP mRNA positivity and recurrence related mortality had no statistical significance (P=0.836).CONCLUSION: From our study, perioperative detection of hAFP mRNA in peripheral blood of patients has no clinical relevance and significant role in the prediction of HCC recurrence. Surgical resection itself may not accelerate cancer dissemination and does not increase postoperative recurrence significantly either.

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No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer

Cited by 116 publications

References 19 publications

Modified hanging manoeuvre facilitates inferior vena cava resection and reconstruction during extended right hepatectomy: A technical case report

Modified hanging manoeuvre facilitates inferior vena cava resection and reconstruction during extended right hepatectomy: A technical case report

Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer

Does surgical resection of hepatocellular carcinoma accelerate cancer dissemination?

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