No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats

Matsumoto, Mariko; Serizawa, Hideki; Sunaga, Masao; Kato, Hina; Takahashi, Mika; Hirata-Koizumi, Mutsuko; Ono, Atsushi; Kamata, Eiichi; Hirose, Akihiko

doi:10.2131/jts.37.463

Cited by 24 publications

(16 citation statements)

References 23 publications

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“…Sharma et al, [10] showed that nanoparticles were mainly found to be retained in the liver after 14 day of sub-acute oral exposure to ZnO-NPs at a higher dose (300 mg/kg). However, Matsumoto et al, [33] suggested that repeated oral gavage of nanoparticles reached the gastro-intestinal tract as agglomerates and were mostly excreted via faeces but no investigations and results to support this suggestion were presented. Further characterization of nanoparticles in the gastrointestinal tract, including both absorption and excretion in response to ZnO-NPs intake are needed.…”

Section: Discussionmentioning

confidence: 99%

Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats

Benslama¹,

Amara²,

Mrad³

et al. 2015

J Nanomed Nanotechnol

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ZnO-NPs suspended in distilled water were administered to Wistar rats at dose of 10 mg/ kg body weight through oral gavage for 5 consecutive days. The mean body weight gain in rats given ZnO-NPs was similar to this of control group, so no significant differences in the relative organs weight were observed between the ZnO-NPs treated-rats and control. Moreover, ZnO-NPs-exposed rats showed normal values for the complete blood count test. However, biochemical assays showed that sub-acute exposure to ZnO-NPs induced a marked increase of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Therefore, uric acid, creatinine and glucose levels are not modulated by ZnO-NPs administration. These biochemical findings were supported by histopathology examination, which showed minor morphological changes in rat tissues. Sub-acute exposure to ZnO-NPs does not affect the exploratory behaviors and the anxious index of rats. Zinc oxide nanoparticles (ZnO) applications Electronic industry, instrumental industry, manufacture, electrical device, radio, wireless fluorescence lamp, image recorder, rheostat, Journal of Nanomedicine & Nanotechnology J o u rna l of N a n o m ed icine & N a n o te chnolo g y

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Section: Discussionmentioning

confidence: 99%

Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats

Benslama¹,

Amara²,

Mrad³

et al. 2015

J Nanomed Nanotechnol

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“…In regard to carbon-based NMs, there were no treatment-related effects in rats upon 28-day oral exposure to 12.5 mg/kg single-walled carbon nanotubes (SWCNTs; basic morphology sheet form consisting of entangled CNTs, diameter 2 nm) or 50 mg/kg multi-walled carbon nanotubes (MWCNTs; basic morphology entangled CNTs, diameter 30 nm; Matsumoto et al 2012). Nevertheless, Matsumoto et al conclude that, due to CNT absorption and persistence, longer-term effects of these materials cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Effects of SiO2, ZrO2, and BaSO4 nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

Buesen

Landsiedel

Sauer³

et al. 2014

Arch Toxicol

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The effects of seven nanomaterials (four amorphous silicon dioxides with or without surface functionalization, two surface-functionalized zirconium dioxides, and barium sulfate) upon 28-day oral exposure to male or female rats were investigated. The studies were performed as limit tests in accordance with OECD Test Guideline 407 applying 1,000 mg test substance/kg body weight/day. Additionally, the acute phase proteins haptoglobin and α2-macroglobulin as well as cardiac troponin I were determined, and metabolome analysis was performed in plasma samples. There were no test substance-related adverse effects for any of the seven nanomaterials. Moreover, metabolomics changes were below the threshold of effects. Since test substance organ burden was not analyzed, it was not possible to establish whether the lack of findings related to the absence of systemic exposure of the tested nanomaterials or if the substances are devoid of any potential for toxicity. The few published subacute oral or short-term inhalation studies investigating comparable nanomaterials (SiO2, ZrO2, and BaSO4) also do not report the occurrence of pronounced treatment-related findings. Overall, the results of the present survey provide a first indication that the tested nanomaterials neither cause local nor systemic effects upon subacute oral administration under the selected experimental conditions. Further investigations should aim at elucidating the extent of gastrointestinal absorption of surface-functionalized nanomaterials. Electronic supplementary materialThe online version of this article (doi:10.1007/s00204-014-1337-0) contains supplementary material, which is available to authorized users.

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“…None of the tested nanomaterials cause local or systemic effects (Buesen et al, 2014). Similarly, studies performed by Matsumoto and co-workers did not reveal toxic effects after acute and repeated oral doses of single-or multi-wall carbon nanotubes (Matsumoto et al, 2012). The toxicity of MWCNTs is more adverse in the case of inhalation as compared to oral exposure.…”

Section: Mammalian Toxicity (Rodents)mentioning

confidence: 72%

Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing

Mendonça

Rizoli

Ávila

et al. 2017

Front. Environ. Sci.

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Over the last decade, engineered nanomaterials (NMs) brought a revolutionary development in many sectors of human life including electronics, paints, textiles, food, agriculture, and health care. However, the exponential growth in the number of NMs applications resulted in uncertainties regarding their environmental impacts. Currently, the common approach for assessing the toxicity of NMs such as, carbon-(fullerenes, single-and multi-walled carbon nanotubes), mineral-(gold and silver nanoparticles, cerium and zinc oxide, silicon and titanium dioxide), and organic-based NMs (dendrimers) includes standard guidelines applied to all chemical compounds. Nevertheless, NMs differ from traditional materials as their physicochemical and surface properties influence the toxic rather than their composition alone. Considering such NMs specificities, adaptations in some methods are necessary to ensure that environmental and human health risks are accurately investigated. In this context, the focus of this mini-review is to summarize the current knowledge in nanotoxicology regarding relevant organisms and experimental assays for assessing the terrestrial toxicity of NMs.

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No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats

Cited by 24 publications

References 23 publications

Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats

Sub-Acute Oral Toxicity of Zinc Oxide Nanoparticles in Male Rats

Effects of SiO2, ZrO2, and BaSO4 nanomaterials with or without surface functionalization upon 28-day oral exposure to rats

Nanomaterials in the Environment: Perspectives on in Vivo Terrestrial Toxicity Testing

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