NOAA Operational Environmental Satellites for Earth Monitoring

Kogan, Felix

doi:10.1007/978-3-030-46020-4_4

Cited by 3 publications

(4 citation statements)

References 61 publications

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“…Several parasitic pathogens are involved in various diseases in humans, and the gravity of the disease is directly connected to the host's immune status. Malaria is a mosquito-borne disease infecting 40% of the population of the African, Southeast Asian, and Western Pacific regions [33]. Six species of Plasmodium cause mortality.…”

Section: Human Parasitic Illnessmentioning

confidence: 99%

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Mohapatra,

Nayak,

Ganeshpurkar

et al. 2024

DDC

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Ongoing therapy for human parasite infections has a few known drugs but with serious side effects and the problem of drug resistance, impelling us to discover novel drug candidates with newer mechanisms of action. Universally, this has boosted the research in the design and development of novel medicinal agents as antiparasitic drugs with a novel mode of action. Histone deacetylase inhibitors (HDACis) are used in a vast variety of diseases due to their anti-inflammatory properties. Drug repurposing strategies have already approved HDACis as cancer therapeutics and are now under investigation for many parasitic infections. Along with the expression of the gene, histone deacetylase (HDAC) enzymes also act as a slice of great multi-subunit complexes, targeting many non-histones, changing systemic and cellular levels signaling, and producing different cell-based specified effects. Zinc (Zn2+)- and nicotinamide adenine dinucleotide (NAD+)-dependent HDACs of parasites play pivotal roles in the alteration of gene expression of parasites. Some of them are already known to be responsible for the survival of several parasites under odd circumstances; thus, targeting them for therapeutic interventions will be novel for potential antiparasitic targets. This point of view outlines the knowledge of both class-I and class-II HDACis and sirtuin inhibitors that emerged to be the key players in the treatment of human parasitic disorders like Leishmaniasis, Schistosomiasis, Malaria, Trypanosomiasis, and Toxoplasmosis. This review also focuses on repurposing opportunities and challenges in HDAC inhibitors that are preceded by their clinical development as potent new antiparasitic drugs.

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Section: Human Parasitic Illnessmentioning

confidence: 99%

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Mohapatra,

Nayak,

Ganeshpurkar

et al. 2024

DDC

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“…In addition to its impact on morbidity and mortality, the occurrence of malaria results in vast social and economic consequences. The economic costs are directly related to seeking treatment or preventive measures, or indirectly related to low productivity due to absenteeism from school or work, and time lost caring for the sick [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…sleeping under LLINs; (2). installing screening in windows, vents and open eaves to prevent mosquito entry into houses; (3). IRS; (4).…”

Section: Introductionmentioning

confidence: 99%

Integrated malaria prevention in low- and middle-income countries: a systematic review

Musoke

Atusingwize

Namata

et al. 2023

Malar J

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Background As many countries aim to eliminate malaria, use of comprehensive approaches targeting the mosquito vector and environment are needed. Integrated malaria prevention advocates the use of several malaria prevention measures holistically at households and in the community. The aim of this systematic review was to collate and summarize the impact of integrated malaria prevention in low- and middle-income countries on malaria burden. Methods Literature on integrated malaria prevention, defined as the use of two or more malaria prevention methods holistically, was searched from 1st January 2001 to 31st July 2021. The primary outcome variables were malaria incidence and prevalence, while the secondary outcome measures were human biting and entomological inoculation rates, and mosquito mortality. Results A total of 10,931 studies were identified by the search strategy. After screening, 57 articles were included in the review. Studies included cluster randomized controlled trials, longitudinal studies, programme evaluations, experimental hut/houses, and field trials. Various interventions were used, mainly combinations of two or three malaria prevention methods including insecticide-treated nets (ITNs), indoor residual spraying (IRS), topical repellents, insecticide sprays, microbial larvicides, and house improvements including screening, insecticide-treated wall hangings, and screening of eaves. The most common methods used in integrated malaria prevention were ITNs and IRS, followed by ITNs and topical repellents. There was reduced incidence and prevalence of malaria when multiple malaria prevention methods were used compared to single methods. Mosquito human biting and entomological inoculation rates were significantly reduced, and mosquito mortality increased in use of multiple methods compared to single interventions. However, a few studies showed mixed results or no benefits of using multiple methods to prevent malaria. Conclusion Use of multiple malaria prevention methods was effective in reducing malaria infection and mosquito density in comparison with single methods. Results from this systematic review can be used to inform future research, practice, policy and programming for malaria control in endemic countries.

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“…Malaria cases are common among African and some Asian countries, contributing to up to one million deaths annually [6,7]. According to the World Health Organization (WHO), in 2017, half of the world's population was at risk because of endemic malaria in 90 counties.…”

Section: Introductionmentioning

confidence: 99%

Prescribing trend of treating malaria patients by public and private healthcare facilities in Lahore

Goher,

Hameed Khaliq,

Waleed Yousaf

2022

Bull Pharm Med Res

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Malaria is an infectious disease caused by parasites of the Plasmodium genus. It is one of the major causes of morbidity and mortality worldwide. The World Health Organization (WHO) has recommended artemisinin combination therapy (ACT) to manage malaria among children and adults. However, chloroquine as monotherapy and ACT are commonly prescribed in treating malaria in Pakistan's healthcare delivery system. Therefore, this study assessed the prescribing trends for treating malaria patients in public and private healthcare facilities. Moreover, the study also determined the number of drugs prescribed per prescription by physicians and consultants. This descriptive study was conducted for six months in Lahore's major public and private healthcare facilities. A purposive sampling technique was employed to review 300 malaria patients' prescriptions accessed from the hospital records. Descriptive statistics and the chi-square test were used to achieve the study's objectives. The study showed that most malaria prescriptions were from both public (64.67%) and private healthcare facilities (42.67%) and comprised a dual-drug regimen involving antimalarials, antibiotics, antipyretics, or their combinations. There was a significant difference (p = 0.002) in the prescription trend between public and private healthcare facilities regarding the number of drugs prescribed for treating malaria. Moreover, prescriptions from private healthcare facilities mainly contained antimalarial drugs (58.59%) and antibiotics (17.60%), while most prescriptions from public healthcare facilities contained antipyretics and other drugs (60.67%) (p = 0.001). Most of the consultants prescribed two (66.67%) or three drugs (33.33%), while the prescribing trends of physicians ranged between one and four, which was also statistically significantly different (p = 0.001). In addition, most prescriptions from public healthcare facilities were rationally prescribed (68%). On the other hand, most prescriptions from private healthcare facilities were rational (54%) and semirational (42%). The rationality of prescriptions by public and private healthcare facilities was also significantly different (p = 0.001). Public healthcare facilities were found to exhibit more rational prescribing trends for managing malaria compared to private healthcare facilities, with a focus on prescribing an optimal number of drugs per prescription and a lower usage of antimalarial and antibiotic medications.

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NOAA Operational Environmental Satellites for Earth Monitoring

Cited by 3 publications

References 61 publications

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Opportunities and Difficulties in the Repurposing of HDAC Inhibitors as Antiparasitic Agents

Integrated malaria prevention in low- and middle-income countries: a systematic review

Prescribing trend of treating malaria patients by public and private healthcare facilities in Lahore

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