Nobel chronicle: Fleming and Gratia

Scoville, C de; Brouwer, Christophe De; Dujardin, M.

doi:10.1016/s0140-6736(05)66334-9

Cited by 6 publications

(2 citation statements)

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“…The discovery of antibiotics was the single most important advancement in the treatment of patients with bacterial infection [1]. However, antibiotics gave physicians a false sense of security, leading to both their overprescription and the development of antibiotic resistance.…”

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confidence: 99%

Inhibition ofBacillus anthracisGrowth and Virulence‐Gene Expression by Inhibitors of Quorum‐Sensing

et al. 2005

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Density-dependent gene expression, quorum sensing (QS), involves the synthesis and detection of low-molecular-weight molecules known as autoinducers. Inhibitors of bacterial QS systems offer potential treatment of infections with highly virulent or multidrug-resistant agents. We studied the effects on Bacillus anthracis growth and the virulence gene (pagA, lef, and cya) expression of the QS inhibitor (5Z)-4-bromo-5-(bromomethylene)-3-butyl-2(5H)-furanone, which is naturally synthesized by the marine alga Delisea pulchra, as well as a related compound and synthetic derivatives. Growth of B. anthracis Sterne strain was substantially reduced in the presence of each furanone in a dose-dependent manner. When furanones were added to midlog-phase cultures of B. anthracis strains with LacZ reporters in pagA, lef, or cya, growth was inhibited, and expression of these virulence genes was inhibited to a proportionately greater extent. These data suggest that use of QS inhibitors could represent novel therapies for anthrax.

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confidence: 99%

Inhibition ofBacillus anthracisGrowth and Virulence‐Gene Expression by Inhibitors of Quorum‐Sensing

et al. 2005

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“…Since the first antibiotic, penicillin, was introduced via the pioneering work of André Gratia and Alexander Fleming in the 1920s [ 9 ], many antibiotics and disinfectants have been successively discovered and commercialized. Since then, antibiotic resistance has spread among common pathogens, such that global human and veterinary communities have faced the emergence of multidrug-resistant (MDR) bacteria.…”

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confidence: 99%

Antimicrobial Activity of Ligilactobacillus animalis SWLA-1 and Its Cell-Free Supernatant against Multidrug-Resistant Bacteria and Its Potential Use as an Alternative to Antimicrobial Agents

Lee

Park

et al. 2023

Microorganisms

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The emergence of multidrug-resistant (MDR) bacteria and the spread of antimicrobial resistance among various bacteria are major threats to the global community. Due to the increased failure of classical antibiotic treatments against MDR bacterial infections, probiotics and their antimicrobial compounds have been suggested as promising alternatives to deal with MDR bacteria. Various strains of lactic acid bacteria have been reported to produce antagonistic molecules against pathogens. A new strain of Ligilactobacillus animalis, L. animalis SWLA-1, isolated from the feces of healthy dogs, shows strong antimicrobial activity against not only common pathogens but also MDR bacteria. In this study, we compared the antimicrobial activity of L. animalis SWLA-1 with that of other lactobacilli and antibiotics using an agar spot assay. Additionally, a novel spot inhibition index was developed and validated to quantitively evaluate the inhibitory activities of lactobacilli and antibiotics. A competitive coculture assay of L. animalis SWLA-1 with MDR bacteria further demonstrated its antibacterial activity. Furthermore, we evaluated the antimicrobial activity of the cell-free supernatant (CFS) of L. animalis SWLA-1 and its stability under various conditions in vitro. We found that L. animalis SWLA-1 and its CFS are potential alternatives to classic antimicrobial agents.

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Uninvited Guests: a Chronology of Petri Dish Contaminations

Shama

2021

Advances in Applied Microbiology

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Nobel chronicle: Fleming and Gratia

Cited by 6 publications

References 1 publication

Inhibition ofBacillus anthracisGrowth and Virulence‐Gene Expression by Inhibitors of Quorum‐Sensing

Inhibition ofBacillus anthracisGrowth and Virulence‐Gene Expression by Inhibitors of Quorum‐Sensing

Antimicrobial Activity of Ligilactobacillus animalis SWLA-1 and Its Cell-Free Supernatant against Multidrug-Resistant Bacteria and Its Potential Use as an Alternative to Antimicrobial Agents

Uninvited Guests: a Chronology of Petri Dish Contaminations

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