Nobel somatosensations and pain

Reeh, Peter W.; Fischer, Michael J.M.

doi:10.1007/s00424-022-02667-x

Cited by 20 publications

(10 citation statements)

References 188 publications

(202 reference statements)

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“…For example, mechanical stimulus is a common interoceptive signal in many organs. Interestingly, although at the macroscopic level mechanical stimuli may trigger distinct forms of tissue deformation in different organs, a family of mechanosensitive ion channels, PIEZO1 and PIEZO2, is widely employed to sense such mechanical changes all over the body ( 5 ). This seemingly surprising observation that one class of receptor could function under so many conditions is likely because only microscopic changes such as physical displacement of molecules and changes in cell membrane curvature can be directly sensed at the molecular level ( 6 ).…”

Section: The Common and Specific Properties Of Interoceptive Signalsmentioning

confidence: 99%

The Coding Logic of Interoception

Wang,

Chang

2024

Annu. Rev. Physiol.

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Interoception, the ability to precisely and timely sense internal body signals, is critical for life. The interoceptive system monitors a large variety of mechanical, chemical, hormonal, and pathological cues using specialized organ cells, organ innervating neurons, and brain sensory neurons. It is important for maintaining body homeostasis, providing motivational drives, and regulating autonomic, cognitive, and behavioral functions. However, compared to external sensory systems, our knowledge about how diverse body signals are coded at a system level is quite limited. In this review, we focus on the unique features of interoceptive signals and the organization of the interoceptive system, with the goal of better understanding the coding logic of interoception. Expected final online publication date for the Annual Review of Physiology, Volume 86 is February 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: The Common and Specific Properties Of Interoceptive Signalsmentioning

confidence: 99%

The Coding Logic of Interoception

Wang,

Chang

2024

Annu. Rev. Physiol.

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“…TRPV1 is a non-selective cation channel with relatively high permeability to Ca 2+ ions, which is a major player in pain perception activated by different factors, including heat, inflammation, and acidic environment as revealed by David Julius, that shared the 2021 Nobel Prize for Physiology or Medicine [158][159][160]. Indeed, TRPV1 plays a key role in acidosis-induced pain, acting as a proton channel and being directly activated by protons [78,161].…”

Section: Trp Vanilloid Subfamilymentioning

confidence: 99%

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Audero

Prevarskaya

Fiorio

2022

IJMS

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Solid tumours are characterised by an altered microenvironment (TME) from the physicochemical point of view, displaying a highly hypoxic and acidic interstitial fluid. Hypoxia results from uncontrolled proliferation, aberrant vascularization and altered cancer cell metabolism. Tumour cellular apparatus adapts to hypoxia by altering its metabolism and behaviour, increasing its migratory and metastatic abilities by the acquisition of a mesenchymal phenotype and selection of aggressive tumour cell clones. Extracellular acidosis is considered a cancer hallmark, acting as a driver of cancer aggressiveness by promoting tumour metastasis and chemoresistance via the selection of more aggressive cell phenotypes, although the underlying mechanism is still not clear. In this context, Ca2+ channels represent good target candidates due to their ability to integrate signals from the TME. Ca2+ channels are pH and hypoxia sensors and alterations in Ca2+ homeostasis in cancer progression and vascularization have been extensively reported. In the present review, we present an up—to—date and critical view on Ca2+ permeable ion channels, with a major focus on TRPs, SOCs and PIEZO channels, which are modulated by tumour hypoxia and acidosis, as well as the consequent role of the altered Ca2+ signals on cancer progression hallmarks. We believe that a deeper comprehension of the Ca2+ signalling and acidic pH/hypoxia interplay will break new ground for the discovery of alternative and attractive therapeutic targets.

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“…TRPV1 is a non-selective cation channel with relatively high permeability to Ca 2+ ions, which is a major player in pain perception activated by different factors, including heat, inflammation and acidic environment as revealed by David Julius that shared the 2021 Nobel Prize for Physiology or Medicine [91][92][93]. Indeed, TRPV1 plays a key role in acidosis-induced pain, acting as a proton channel and being directly activated by protons [94,95].…”

Section: Trp Vanilloid Subfamilymentioning

confidence: 99%

Ca<sup>2+</sup> Signaling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Audero¹,

Prevarskaya²,

Fiorio³

2022

Preprint

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Solid tumours are characterized by an altered microenvironment (TME) from the physi-cochemical point of view, displaying a highly hypoxic and acidic interstitial fluid. Hy-poxia results from uncontrolled proliferation, aberrant vascularization and altered can-cer cell metabolism. Tumour cellular apparatus adapt to hypoxia by altering its metab-olism and behaviour, increasing its migratory and metastatic abilities by acquisition of a mesenchymal phenotype and selection of aggressive tumour cell clones. Extracellular acidosis is considered a cancer hallmark, acting as a driver of cancer aggressiveness by promoting tumour metastasis and chemoresistance by selecting for more aggressive cell phenotypes, although the underlying mechanism is still not clear. In this context, Ca2+ channels represent good target candidates due to their ability to integrate signals from the TME. Ca2+ channels are pH and hypoxia sensors and alterations in Ca2+ homeostasis in cancer progression and vascularization have been extensively reported. The present review will focus on Ca2+ permeable ion channels, with a major focus on TRP, SOC and PIEZO channels, that are modulated by tumour hypoxia and acidosis as well as the role of the resulted altered Ca2+ signals on cancer progression hallmarks. A deeper compre-hension of the Ca2+ signaling and acidic pH/hypoxia interplay will break new ground for the discovery of alternative and attractive therapeutics targets.

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Nobel somatosensations and pain

Cited by 20 publications

References 188 publications

The Coding Logic of Interoception

The Coding Logic of Interoception

Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Ca<sup>2+</sup> Signaling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

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