Noble metal nanomaterials for the diagnosis and treatment of hematological malignancies

Huang, Xin; Mahmudul, Hasan Md; Li, Zengbei; Deng, Xinjie; Su, Xiaozhou; Xiao, Zhongqing; Zhao, Lingyun; Liu, Ting; Liu, Hongyun

doi:10.31083/j.fbl2702040

Cited by 15 publications

(11 citation statements)

References 128 publications

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“…Because of this heterogeneity, there is no unified standard diagnostic method for their diagnosis and treatment ( Bochtler et al, 2018 ). In recent years, although there have been an increasing number of diagnostic procedures for hematological tumors, with the development of Raman spectroscopy and its wide application in many fields, its value in the diagnosis of tumor biology is also increasing ( Huang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in the application of Raman spectroscopy in haematological tumours

Liang

Shi

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Hematologic malignancies are a diverse collection of cancers that affect the blood, bone marrow, and organs. They have a very unpredictable prognosis and recur after treatment. Leukemia, lymphoma, and myeloma are the most prevalent symptoms. Despite advancements in chemotherapy and supportive care, the incidence rate and mortality of patients with hematological malignancies remain high. Additionally, there are issues with the clinical diagnosis because several hematological malignancies lack defined, systematic diagnostic criteria. This work provided an overview of the fundamentals, benefits, and limitations of Raman spectroscopy and its use in hematological cancers. The alterations of trace substances can be recognized using Raman spectroscopy. High sensitivity, non-destructive, quick, real-time, and other attributes define it. Clinicians must promptly identify disorders and keep track of analytes in biological fluids. For instance, surface-enhanced Raman spectroscopy is employed in diagnosing gene mutations in myelodysplastic syndromes due to its high sensitivity and multiple detection benefits. Serum indicators for multiple myeloma have been routinely used for detection. The simultaneous observation of DNA strand modifications and the production of new molecular bonds by tip-enhanced Raman spectroscopy is of tremendous significance for diagnosing lymphoma and multiple myeloma with unidentified diagnostic criteria.

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Section: Introductionmentioning

confidence: 99%

Advances in the application of Raman spectroscopy in haematological tumours

Liang

Shi

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Section: Introductionmentioning

confidence: 99%

“…Recently, Huang et al ( 2022) [34] reported on the applications of metal nanomaterials in the diagnosis and treatment of HMs. However, detailed discussions on GNMs were not observed in that review [34]. In the current review, we included research articles published before February 2021 that covered our topics of interest (i.e., GNMs and HMs).…”

Section: Introductionmentioning

confidence: 99%

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies

Shakil

Niloy

Mahmud

et al. 2022

Cancers

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Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs’ diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic drugs are losing their efficacy due to adverse effects, and many patients develop resistance against these drugs. To overcome these limitations, the development of novel potent and reliable theranostic agents is urgently needed to diagnose and combat HMs at an early stage. Recently, gold nanomaterials (GNMs) have shown promise in the diagnosis and treatment of HMs. Magnetic resonance and the surface-plasmon-resonance properties of GNMs have made them a suitable candidate in the diagnosis of HMs via magnetic-resonance imaging and colorimetric or electrochemical sensing of cancer-specific biomarkers. Furthermore, GNMs-based photodynamic therapy, photothermal therapy, radiation therapy, and targeted drug delivery enhanced the selectivity and efficacy of anticancer drugs or drug candidates. Therefore, surface-tuned GNMs could be used as sensitive, reliable, and accurate early HMs, metastatic HMs, and MRD-detection tools, as well as selective, potent anticancer agents. However, GNMs may induce endothelial leakage to exacerbate cancer metastasis. Studies using clinical patient samples, patient-derived HMs models, or healthy-animal models could give a precise idea about their theranostic potential as well as biocompatibility. The present review will investigate the theranostic potential of vectorized GNMs in HMs and future challenges before clinical theranostic applications in HMs.

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“…Information on the Our World in Data website shows that an estimated 9.6 million people died of various forms of cancer in 2017. With the rising morbidity and mortality, cancer is a serious threat to human health and has become a major global public health problem [3]. Therefore, it is imperative that the search for effective cancer drugs is accelerated.…”

Section: Introductionmentioning

confidence: 99%

Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles

Zhang¹,

Li²,

Liu³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Lactate dehydrogenase (LDH) is one of the important enzyme systems for glycolysis and gluconeogenesis. It can catalyze the reduction and oxidation reaction between propionic acid and L-lactic acid, which is usually overexpressed in cancer cells. Therefore, inhibiting the activity of LDH is a promising way for the treatment of cancer. In this study, an effective method based on ligand fishing and ultra performance liquid chromatography-mass spectrum (UPLC-MS) was established to screen and identify active ingredients from Selaginella doederleinii with potential inhibitory activity for LDH. Methods: Firstly, LDH was immobilized on the magnetic nanoparticles (MNPs), three immobilization parameters including LDH concentration, immobilization time and pH were optimized by single factor and response surface methodology for maximum (max) immobilization yield. Then, a mixed model of galloflavin and chlorogenic acid (inhibitors and non-inhibitors of LDH) was used to verify the specificity of immobilized LDH ligand fishing, and the conditions of ligand fishing were further optimized. Finally, combined with UPLC-MS, immobilized LDH was used to simultaneously screen and identify potential LDH inhibitors from the ethyl acetate extract of Selaginella doederleinii. Results: The prepared fishing material was comprehensively characterized by scanning electron microscopy (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and fourier transform infrared spectrometer (FT-IR). The optimal immobilization conditions were obtained as LDH concentration of 0.7 mg/mL, pH value of 4.5, and immobilization time of 3.5 h. Under these conditions, the max immobilization yield was (3.79 ± 0.08) × 10 3 U/g. The specificity analysis showed that immobilized LDH could recognize and capture ligands, and the optimal ligand fishing conditions included that the incubation time was 30 min, the elution time was 20 min, and the concentration of methanol as eluent was 80%. Finally, two LDH inhibitors, amentoflavone and robustaflavone, were screened by immobilized LDH from the ethyl acetate extract of Selaginella doederleinii. Conclusions: The study provided a meaningful evidence for discovering the bioactive constituents in ethyl acetate extract of Selaginella doederleinii related to cancer treatment, and this ligand fishing method was feasible for screening enzyme inhibitors from similar complex mixtures.

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Noble metal nanomaterials for the diagnosis and treatment of hematological malignancies

Cited by 15 publications

References 128 publications

Advances in the application of Raman spectroscopy in haematological tumours

Advances in the application of Raman spectroscopy in haematological tumours

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies

Lactate Dehydrogenase-Inhibitors Isolated from Ethyl Acetate Extract of Selaginella doederleinii by Using a Rapid Screening Method with Enzyme-Immobilized Magnetic Nanoparticles

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