Noble metals in medicine: Latest advances

Silver coordination compounds: A new horizon in medicine

“…Nowadays a quick review of the literature reveals that the most common aim in making new silver complexes is to test them for biological activity. In fact, silver compounds, also in the form of nanoparticles [1,2], are very interesting in the field of medicine, since they combine the traditional use of this metal as a remedy for many diseases with the relative "novelty" of metallo drugs, which suddenly became popular with the introduction of cisplatin as a powerful chemotherapeutic agent about 40 years ago.…”

Synthesis and antimicrobial properties of lipophilic Schiff base copper and palladium complexes

“…NMR spectra were recorded on a JEOL JNM-GSX400 FT NMR spectrometer. 1 H NMR chemical shifts are reported in ppm and are referenced to residual protons in deuterated solvent at 400 MHz. 13 C NMR chemical shifts are referenced to solvent carbon resonances as internal standards at 100 MHz.…”

“…Although the history of medicinal inorganic chemistry is a rich tapestry of random discoveries, the most important chapter in this story comes from the serendipitous observation that cisplatin, cis-[PtCl 2 (NH 3 ) 2 ], inhibited cellular division in Escherichia coli [1]. Since this remarkable discovery, cisplatin has become a powerful anticancer drug for the treatment of ovarian and testicular tumors and given birth to a new age of metal-based medicine.…”

Metal-based glycoconjugates and their potential in targeted anticancer chemotherapy

“…Starting from the accidental discovery of the therapeutic effectiveness of cisplatin in the mid-1960s, research has been generating an impressive number of both platinum-and other metal-based anticancer agents [48][49][50]. Unfortunately, poor bioavailability, water solubility and stability under physiological conditions, along with lack of tumor selectivity and overall toxicity of the metal derivatives proved detrimental.…”