1971
DOI: 10.1016/0002-9343(71)90224-5
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Nocardia asteroides infection complicating neoplastic disease

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Cited by 179 publications
(59 citation statements)
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“…Since this first report, several hundred cases of primary pulmonary nocardiosis occurring in both healthy and immunocompromised individuals have been described in the literature. The pathologic feature of pulmonary nocardiosis is usually a suppurative response, but a granulomatous response or a mixture of these resulting in radiographic presentations that are pleomorphic and not specific may occur (38,237,393,395,506,734). The manifestation within the lungs may vary from a mild, diffuse infiltration to a lobar or multilobar consolidation (Fig.…”
Section: Pulmonary Nocardiosismentioning
confidence: 99%
“…Since this first report, several hundred cases of primary pulmonary nocardiosis occurring in both healthy and immunocompromised individuals have been described in the literature. The pathologic feature of pulmonary nocardiosis is usually a suppurative response, but a granulomatous response or a mixture of these resulting in radiographic presentations that are pleomorphic and not specific may occur (38,237,393,395,506,734). The manifestation within the lungs may vary from a mild, diffuse infiltration to a lobar or multilobar consolidation (Fig.…”
Section: Pulmonary Nocardiosismentioning
confidence: 99%
“…have also rarely been implicated as a cause of mild clinical infections in humans, including pharyngitis, bronchitis, and otitis media (341). Young et al described seven patients (none on steroids) with fever or upper respiratory tract symptoms; all had sputum cultures positive for Nocardia spp., and all recovered without antimicrobial therapy (657). Underlying pulmonary disorders, in particular, those associated with bronchial obstruction or decreased bronchociliary clearance (e.g., malignancy, tuberculosis, cystic fibrosis, asthma, bronchitis, and allergic aspergillosis), may predispose patients to respiratory tract colonization with Nocardia spp.…”
Section: Epidemiologic Aspects Of Infection In Humansmentioning
confidence: 99%
“…However, the infection may also involve many other deep organs, including the kidneys (9,307,466,497,654), spleen (307,654), liver (307,460,484,497,654) and, rarely, bone (10,20,26,139,232,325,327,377,446,487,525,652), skin (71,127,282,416,658), and joints (71,111,123,144,299). In the brain and other organs, abscess formation is a particularly common pathologic manifestation of disseminated nocardiosis (457,657).…”
Section: Epidemiologic Aspects Of Infection In Humansmentioning
confidence: 99%
“…Therefore, these drugs have been under study (Karakusis et al 1982) as initial therapy in febrile immune-impaired hosts, where prompt broad-spectrum therapeutic activity is critical, until the etiologic agent(s) can be defined. Nocardial infections are particularly a problem of immune-impaired hosts (Young et al 1971). The present study suggests that the clinician starting cefotaxime for broad-spectrum therapy in the setting of a febrile illness in an immune-impaired host would be thus including coverage for the possibility of nocardial infection.…”
Section: Discussionmentioning
confidence: 99%