Nocardia asteroides peritoneal dialysis-related peritonitis: First case in pediatrics, treated with protracted linezolid

El-Naggari, Mohamed; Nour, Ibtisam El; Al-Nabhani, Dana; Muharrmi, Zakaria Al; Gaafar, Heba; Abdelmogheth, Anas A.W.

doi:10.1016/j.jiph.2015.11.003

Cited by 5 publications

(8 citation statements)

References 18 publications

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“…These effects might have been sufficient in the present case, in addition to macrolides antibiotics such as CAM and azithromycin which are also known to exert immunomodulatory effects [14,15]. Furthermore, LZD is known to show very good penetration into most tissues in humans, and a full dose can be used even in patients with renal failure, including patients on CAPD as in the present case [16,17].…”

Section: Discussionmentioning

confidence: 80%

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

et al. 2020

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Objective: Rare disease Background: Mycobacterium abscessus is one of the most important mycobacteria, but its associated peritonitis in patients on continuous ambulatory peritoneal dialysis (CAPD) appears relative rare, and the treatment regimen of the antibiotics are still unclear. Case Report: A 38-year-old female with chronic glomerulonephritis on CAPD who was diagnosed with M. abscessus-associated peritonitis. Symptoms exacerbated despite treatment with a 3-antibiotic regimen combining clarithromycin, imipenem/cilastatin (IPM/CS), and minocycline (MINO). However, after changing IPM/CS and MINO to linezolid (LZD), her condition and inflammation improved, and she was able to be maintained on oral tedizolid (TZD). Conclusions: Oxazolidinones such as LZD and TZD might be candidate antibiotics for the treatment of M. abscessus-associated diseases with chronic renal failure due to their immunomodulatory effects and non-renal excretion.

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Section: Discussionmentioning

confidence: 80%

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

et al. 2020

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“…Presumably, respiratory acquisition of Nocardia in immunosuppressed patients is followed by hematologic dissemination, eventually allowing infection at distant sites [ 22 , 38 ]. Additionally, direct peritoneal inoculation has been reported in 12 cases of Nocardia peritonitis in patients on peritoneal dialysis [ 8 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…Here, we report the second case, to our knowledge, of isolated abdominal nocardiosis due to Nocardia paucivorans . We also provide a comprehensive review of the literature, summarizing the information on 39 previously published cases of intra-abdominal and retroperitoneal nocardiosis and 12 cases of peritoneal dialysis-related nocardia peritonitis [ 2 , 5 , 6 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. Finally, we will review published cases of infection with Nocardia paucivorans , a rare nocardial species.…”

Section: Introductionmentioning

confidence: 99%

Intra-Abdominal Nocardiosis—Case Report and Review of the Literature

Tramèr

Mertz

Huegli

et al. 2020

JCM

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Nocardiosis is primarily an opportunistic infection affecting immunosuppressed individuals, in whom it most commonly presents as pulmonary infection and sometimes cerebral abscesses. Isolated abdominal or retroperitoneal nocardiosis is rare. Here, we report the second case, to our knowledge, of isolated abdominal nocardiosis due to Nocardia paucivorans and provide a comprehensive review of intra-abdominal nocardiosis. The acquisition of abdominal nocardiosis is believed to occur via hematogenous spreading after pulmonary or percutaneous inoculation or possibly via direct abdominal inoculation. Cases of Nocardia peritonitis have been reported in patients on peritoneal dialysis. Accurate diagnosis of abdominal nocardiosis requires histological and/or microbiological examination of appropriate, radiologically or surgically obtained biopsy specimens. Malignancy may initially be suspected when the patient presents with an abdominal mass. Successful therapy usually includes either percutaneous or surgical abscess drainage plus prolonged combination antimicrobial therapy.

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“…Our patient had N farcinica abdominal abscesses but there was no brain involvement. In children on PD, nocardia peritonitis has been described …”

Section: Discussionmentioning

confidence: 99%

“…In children on PD, nocardia peritonitis has been described. 29 Primary abdominal nocardiosis without evidence of systemic or pulmonary infection is limited to some case reports. Abdominal nocardiosis has been described in an immunocompetent adult with successful resolution with amikacin and sulfonamide, 30 in a young female with Crohn's disease 31 and in an immunocompromised retroviral infected adult with mortality.…”

Section: Discussionmentioning

confidence: 99%

Isolated abdominal nocardiosis in a pediatric renal transplant recipient

Acharya

Amin

Rajderkar

et al. 2019

Pediatric Transplantation

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Nocardia infection after RT is uncommon. The most common modes of exposure are inhalation of dust containing nocardia or contaminated soil/water and surgical instruments. Isolated abdominal nocardiosis following RT has not been reported. We report an 11‐year‐old female who developed nocardia abscesses of the abdomen post‐RT. ESRD was secondary to FSGS and she had received multiple immunosuppressive agents prior to transplant. Induction immunosuppression consisted of thymoglobulin and maintenance was with tacrolimus, mycophenolate, and prednisone. There were construction activities in the hospital ward during her hospital stay. Due to immediate recurrence of FSGS in the allograft, she received plasma exchange, rituximab, and IVIG. Anti‐infective prophylaxis consisted of TMP‐SMX, valganciclovir, and nystatin. She developed multiple loculated fluid collections in the abdomen 6 weeks later. Histology of lesions demonstrated suppurative caseating granulomatous inflammation and the AFB culture showed Nocardia farcinica. With the reduction of immunosuppressive agents along with usage of TMP‐SMX, imipenem‐cilastatin, and linezolid, she had a partial recovery after 9 months with persistent small abscesses but remained asymptomatic clinically. There was no evidence of nocardia infection in lungs and brain. Repeat AFB culture from the lesions was negative. Allograft function remained stable throughout. She remains on oral TMP‐SMX therapy. We postulated that she could have acquired nocardia either from the contaminated air particles in the hospital from the construction activities or reactivation of nocardia from prior colonization. Nocardia infection should be suspected in immunocompromised patients with unexplained fever and abdominal pain.

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Nocardia asteroides peritoneal dialysis-related peritonitis: First case in pediatrics, treated with protracted linezolid

Cited by 5 publications

References 18 publications

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects

Intra-Abdominal Nocardiosis—Case Report and Review of the Literature

Isolated abdominal nocardiosis in a pediatric renal transplant recipient

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