Nocardia brasiliensis-associated femorotibial osteomyelitis

Vanegas, Samuel; Franco-Cendejas, Rafael; Cicero, A.; López-Jácome, Esaú; Colin, Claudia; Hernández, Melissa

doi:10.1016/j.ijid.2013.11.002

Cited by 16 publications

(9 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nocardia infection is characterized by a variety of clinical manifestations with the involvement of the lungs, central nervous system, skin, and other organs. More seriously, Nocardia can cause severe, life-threatening disseminated infections, such as osteomyelitis and nocardial sepsis [5,6]. Early recognition and effective therapy are imperative to achieve successful outcomes.…”

Section: Introductionmentioning

confidence: 99%

Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China

Qian

Mou

et al. 2020

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

Nocardia is a pathogen responsible for a variety of clinical infections. Here, we aimed to investigate the species distribution, clinical manifestations, and antimicrobial susceptibility of Nocardia species in two tertiary general hospitals over 3 years in China. In this retrospective study, a total of 27 Nocardia species were isolated from 27 individuals between January 2017 and December 2019. Nocardia isolates were identified to species level by mass spectrometry and 16S rRNA PCR sequencing. Clinical data were collected from medical records. Antimicrobial susceptibility was determined by standard Broth microdilution method. The 27 patients with Nocardia infection included 12 males and 15 females with a mean age of 60.11 years. Among 27 Nocardia isolates, 7 species were identified, with the most common species being N. otitidiscaviarum (40.7%). The antimicrobial susceptibility profiles varied between different Nocardia species. Notably, all Nocardia isolates were linezolid susceptible. Majority of Nocardia isolates were collected from a department of respiratory medicine (55.56%) and sputum specimen (44.44%). Pulmonary region was the most involved body site (70.37%), followed by skin (7.4%) and pleural cavity (7.4%). Most patients with Nocardia infection needed combination antibiotic therapy. Two deaths were reported during the treatment period and 24 patients achieved improvement after antibiotic therapy. The clinical manifestations of Nocardia infection and antimicrobial susceptibility profiles varied with diverse Nocardia species. Thus, the accurate identification of these species is crucial for the diagnosis and the selection of antibiotic treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China

Qian

Mou

et al. 2020

Bosn J of Basic Med Sci

View full text Add to dashboard Cite

show abstract

“…He was later found to have vertebral osteomyelitis and an epidural abscess with N. brasiliensis [ 6 ]. In another case report, a healthy 21-year-old woman with trauma to the knee complained of gradually worsening pain and swelling of the leg and was found to have femorotibial osteomyelitis due to N. brasiliensis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

First Report of Clivus Osteomyelitis Caused by Nocardia veterana in a Lung Transplant Recipient

Villanueva¹,

Helou²

2023

Cureus

View full text Add to dashboard Cite

Nocardia species have been implicated as a cause of pulmonary, cutaneous, ocular, and disseminated central nervous system disease. Dissemination to the bones, commonly the spine, has also been described in the literature. However, isolated osteomyelitis of the skull base is rare. Additionally, advances in the use of molecular techniques have identified many new Nocardia species, including Nocardia veterana that was thought to be clinically insignificant when it was first identified. Here, we report the clinical features and treatment approach for a lung transplant patient who developed N. veterana clivus osteomyelitis secondary to sphenoid sinusitis. It is the first case of skull base osteomyelitis caused by this rare species of Nocardia.

show abstract

“…[ 16 ] Long-term treatment is a routine choice, but the duration of medication is uncertain. [ 17 ] To treat a particular type of infection, a more extended period of medication is often chosen, accompanied by an increase in the incidence of drug-resistant bacteria and adverse drug reactions. Tissue-specific necrosis usually occurs in particular types of infections such as tuberculosis, which limits the spread of antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Metacarpal tuberculosis with Nocardia infection

et al. 2020

View full text Add to dashboard Cite

Introduction: Isolated metacarpal tuberculosis is rare in orthopedic surgery. In the case of poor efficacy of traditional treatment methods, such as debridement surgery and anti-tuberculosis treatment, it is necessary to consider whether there is a special type of infection. We describe a case of metacarpal tuberculosis with Nocardia infection in a patient. Patient concerns: A 65-year-old male patient who suffered from pain and dysfunction lasted for 6 years. Diagnoses: Confirmation of the diagnosis was finally achieved by isolation of M tuberculosis and Nocardia actinomycetes from bone specimens. Interventions: The patient underwent debridement surgery, Masquelet technique was used during the operation, and oral antibiotics were combined after surgery. Outcomes: Bone graft surgery was performed 6 weeks after the first surgery. We followed up on bone healing at 1 and 3 months postoperatively. Conclusion: Tissue-specific necrosis usually occurs in particular types of infections such as tuberculosis, which limits the spread of antibiotics. Masquelet technique seems to bring new options to solve this problem. The performance of Nocardia infection is similar to that of tuberculosis infection, so it is difficult to identify clinically. Therefore, for cases where tuberculosis is suspected, and anti-tuberculosis treatment is ineffective, the possibility of Nocardia infection needs to be considered.

show abstract

Nocardia brasiliensis-associated femorotibial osteomyelitis

Cited by 16 publications

References 15 publications

Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China

Clinical Nocardia species: Identification, clinical characteristics, and antimicrobial susceptibility in Shandong, China

First Report of Clivus Osteomyelitis Caused by Nocardia veterana in a Lung Transplant Recipient

Metacarpal tuberculosis with Nocardia infection

Contact Info

Product

Resources

About