Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma

Davis, Jennifer; Kreppel, Andrew; Brady, Rebecca C.; Jones, Blaise; Stevenson, Charles B.; Fouladi, Maryam; Hummel, Trent R.

doi:10.1097/mph.0000000000000360

Cited by 6 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Central nervous system nocardiosis masquerading brain metastasis is not uncommon and has been reported. 47,82 For example, in a case report by Voide et al, 83 a patient initially diagnosed with non-small cell lung cancer presented delirium during chemotherapy treatment, and subsequently underwent CT and MRI. The brain lesions were initially interpreted as CNS metastasis, but later stereotactic biopsy and Ziehl-Neelsen staining of lesion showed N. farcinica infection.…”

Section: Discussionmentioning

confidence: 99%

Central nervous system nocardiosis diagnosed by metagenomic next-generation sequencing: A case series and literature review

Yuan,

Shen,

Qin

et al. 2023

Adv Clin Exp Med

View full text Add to dashboard Cite

Background. Central nervous system (CNS) nocardiosis is a rare suppurative disease caused by the genus Nocardia. It is found most frequently in immunocompromised individuals.Objectives. In this study, we retrospectively reviewed the clinical presentations, laboratory examination, therapy and outcomes of 9 patients with CNS nocardiosis diagnosed using metagenomic next-generation sequencing (mNGS) in our hospital. Materials and methods.We reviewed 9 patients with confirmed diagnosis of CNS Nocardia infection from January 2017 to December 2021 in the Department of Neurology at The Third Affiliated Hospital, Sun Yat-sen University (Guangzhou, China). In addition, we searched literature related to CNS Nocardia infection on PubMed and included all case reports with proven CNS nocardiosis since 2016.Results. The metagenomic next-generation sequencing (mNGS) of CSF can be used for the rapid diagnosis of nocardiosis in CNS and N. farcinica are the most commonly isolated species. Underlying autoimmune diseases, immunosuppressive agents including corticosteroids and organ transplantation are predisposing factors of developing CNS nocardiosis. Single or multiple hyper-enhanced ring lesions indicative of cerebral abscesses are commonly presented in brain imaging. Trimethoprim-sulfamethoxazole (TMP-SMX) is used as the primary agent for the antibacterial therapy and in combination with other antibacterial agents. Conclusions.Our study demonstrated that mNGS of CSF can be conducted for definitive and rapid diagnosis for CNS nocardiosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Central nervous system nocardiosis diagnosed by metagenomic next-generation sequencing: A case series and literature review

Yuan,

Shen,

Qin

et al. 2023

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Nocardiosis is an uncommon disease caused by aerobic gram-positive bacteria Nocardia spp. [1]. It is an opportunistic infection, which usually affects immunocompromised patients, however one third of patients with nocardiosis may be immunocompetent.…”

Section: Introductionmentioning

confidence: 99%

Nocardia farcinica as a cause of chronic meningitis – case report

et al. 2020

View full text Add to dashboard Cite

Background: Nocardiosis is an uncommon disease caused by aerobic gram-positive bacteria Nocardia spp. Although it is usually an opportunistic infection affecting immunocompromised patients, even one third of cases occur in immunocompetent persons. The aim of the study was to describe the course of chronic meningitis due to Nocardia infection. Case presentation: A 52-year-old patient, chalk miner, suffered from a chronic meningitis caused by an extremely rare pathogen. The patient's history was complicated and diagnostic process covered multiple examinations and consultations. Initially Kocuria rosea was cultured, yet after molecular examination the result was verified to Nocardia farcinica. Targeted antibiotic treatment was implemented, which resulted in gradual improvement of patients condition. A full recovery was achieved after one year antibiotic therapy. Conclusions:

show abstract

Nocardia and actinomyces

Paulsen¹,

Sue²

2021

Pediatric Transplant and Oncology Infectious Diseases

View full text Add to dashboard Cite

Nocardia farcinica Meningitis Masquerading as Central Nervous System Metastasis in a Child With Cerebellar Pilocytic Astrocytoma

Cited by 6 publications

References 19 publications

Central nervous system nocardiosis diagnosed by metagenomic next-generation sequencing: A case series and literature review

Central nervous system nocardiosis diagnosed by metagenomic next-generation sequencing: A case series and literature review

Nocardia farcinica as a cause of chronic meningitis – case report

Nocardia and actinomyces

Contact Info

Product

Resources

About