Nocardiosis in a teaching hospital in the Central Anatolia region of Turkey: treatment and outcome

Yıldız, Orhan; Alp, Emine; Tokgöz, Bülent; Tucer, Bülent; Aygen, Bilgehan; Sümerkan, Bülent; Couble, A.; Boiron, P.; Doğanay, Mehmet

doi:10.1111/j.1469-0691.2005.01145.x

Cited by 46 publications

(54 citation statements)

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“…Recent reviews of collections of Nocardia clinical isolates by genotypic methods have found that a significant proportion, originally identified by routine phenotypic and chemotaxonomic methods, belong to a new species, Nocardia cyriacigeorgica (18,27,29,35). This species was first described in 2001 (38), and strains of N. cyriacigeorgica have since been recovered as the etiologic agent of human infection in Western Europe, Greece, Turkey, Japan, Thailand, and Canada (1,3,6,7,11,17,18,22,27,35,39). Most cases of infection have occurred in the context of human immunodeficiency virus-related or iatrogenic immune suppression.…”

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confidence: 99%

Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Salais¹,

2008

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Nocardia cyriacigeorgica is recognized as an emerging pathogen in many parts of the world. We present the first case description of invasive N. cyriacigeorgica pulmonary infection in the United States identified to the species level by 16S rRNA and hsp65 sequence analysis. A subsequent retrospective molecular screening of recent Nocardia clinical isolates at our New York City medical center yielded an additional six N. cyriacigeorgica isolates. Because routine laboratory algorithms for the phenotypic identification of Nocardia species are limited in practice, the true prevalence of N. cyriacigeorgica infections may be greater than currently appreciated. Indeed, we present evidence confirming that N. cyriacigeorgica is coincident with the unofficial species designation Nocardia asteroides complex antimicrobial susceptibility pattern type VI and distinct from the N. asteroides sensu stricto strain ATCC 19247 T . As nocardial species identity can predict antimicrobial susceptibility and guide clinical management, we offer simplified phenotypic and molecular protocols to assist the identification of N. cyriacigeorgica.

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confidence: 99%

Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Salais¹,

2008

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“…The incidence of human Nocardiosis is not well established in Turkey and comprises mostly case reports and small case series (Yildiz et al, 2005;Mentes et al, 2006;Elmaci et al, 2007;Arslan et al, 2007;Karakan et al, 2007). Pulmonary Nocardiosis is the most common presentation, with dissemination to other parts of the body, especially the brain.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary Nocardiosis is the most common presentation, with dissemination to other parts of the body, especially the brain. Nine pulmonary and/ or cerebral Nocardiosis cases in humans (Yildiz et al, 2005) were defined on the basis of a positive culture and consistent clinical presentation in a retrospective study which performed at Erciyes University Teaching Hospital. Long term treatment of cases was started with ceftriaxone plus amikacin.…”

Section: Discussionmentioning

confidence: 99%

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Submandibular and parotid abscess due to Nocardia sp. and therapy with danofloxacin in sheep

Kırkan

Ural

Parın

et al. 2018

J Hellenic Vet Med Soc

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The aim of the present study was to report detection of Nocardia sp. from cutaneous lesions of sheep. Abscess material was collected from submandibular and parotid lesions in sheep for identification of Nocardia sp., which is well known as a causative agent for cutaneous or subcutaneous abscesses, disseminated disease, mastitis, and pneumonia. Nocardia sp. are Gram-positive, delicate, non-motile, branching filamentous bacteria that found in soil, dust, organic materials, water and aquatic environmental. Nocardia species generally yield a large variety of diseases in both normal and immunocompromised humans and animals. In the present study, bacterial staining methods and biochemical identification methods were applied for identification of Nocardia sp. in four sheep in Aydin. All cases had superficial abscesses in the submandibular and parotid region, mostly invading the head and neck regions. Neutrophilic leukocytosis was evident in three out of four sheep, and there was evidence of moderate anemia in two of the sheep. Samples were stained with Gram and modified Ziehl-Neelsen staining and streaked onto sheep blood agar, incubated at 37°C for 48-72 hours under aerobic condition, Sabouraud Dextrose Agar, incubated for one week under aerobic condition. Nocardia sp. was isolated from based on bacteriological investigation confirming numerous thin, Gram-positive, filamentous and nonacid fast organisms, and biochemical tests. Nocardia sp. strains were confirmed with 16s Rrna PCR method. Based on clinical appearance, hematological findings, and molecular analysis a definitive diagnosis cutaneousNocardiosis was made in the sheep. Initial therapy involving danofloxacin, with regard to antibiogram, for 10 days and local iodine solutions, resulted in clinical recovery on 35-45 days post-treatment. This is the first reported case of cutaneous Nocardiosis and its effective danofloxacin therapy in sheep in Turkey.

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“…The pathogens can be found in environment, such as soil, decomposing vegetation, and other organic matter as well as in fresh and salt water. People with cancer or people taking steroid treatments are at risk for nocardiosis, and the infection often happens via several ways, such as inhalation (pulmonary nocardiosis), traumatic inoculation (cutaneous nocardiosis), and hospital-acquired (extra pulmonary nocardiosis) (204)(205)(206). In Turkey, a solitary case with granulomatous nocardial pleurisy was documented in a dog in Ankara (207).…”

Section: Dermatophilosis Is a Zoonotic Bacterial Infection Caused Bymentioning

confidence: 99%

Overview of Zoonotic Diseases in Turkey: The One Health Concept and Future Threats

İncı¹,

Doğanay²,

Özdarendeli³

et al. 2018

TurkiyeParazitolDerg

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Zoonotic infections are globally important diseases and lead to huge economic losses in both low-and middle-income and high-income countries. Global warming, environmental and ecological changes, illegal movement of animals and humans, regional civil wars, and poverty are predisposing factors for the emergence of zoonotic infections and their distribution worldwide; they are also a big threat for the future. In addition, environmental pollution and antimicrobial resistance are immense serious threats and dangers to prevent and control zoonotic infections. The natural location of Turkey allows many emerged or re-emerged infections with zoonotic characteristics by animal movements, such as bird immigrations, and by human movements due to civil wars as seen with regional refugees. Numerous zoonotic diseases, including 37 bacterial, 13 fungal, 29 viral, 28 parasitic (3 trematodes, 7 cestodes, 10 nematodes, and 8 protozoan), and totally 107 infections, have been reported from Turkey to date. Additionally, many ectoparasitic zoonoses within 15 different arthropod groups and one leech infestation have been reported from Turkey to date. The "One Health" initiative is particularly relevant for developing strategies to combat zoonotic diseases. In this article, we review the occurrence of zoonotic diseases in man and animals in Turkey in the light of the "One Health" perspective.

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Nocardiosis in a teaching hospital in the Central Anatolia region of Turkey: treatment and outcome

Cited by 46 publications

References 20 publications

Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Nocardia cyriacigeorgica , an Emerging Pathogen in the United States

Submandibular and parotid abscess due to Nocardia sp. and therapy with danofloxacin in sheep

Overview of Zoonotic Diseases in Turkey: The One Health Concept and Future Threats

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