Nociceptin stimulates locomotion and exploratory behaviour in mice

Florin, Sébastien; Suaudeau, Charles; Meunier, Jean‐Claude; Costentin, Jean

doi:10.1016/s0014-2999(96)00707-8

Cited by 132 publications

(86 citation statements)

References 11 publications

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“…Such changes in locomotor activity were detected in the ®rst 5 min of testing, and support the use of a 3 min testing period in the present study. However, this subject remains controversial with both decreases (Reinscheid et al, 1995;Devine et al, 1996;Sandin et al, 1997) and increases (Florin et al, 1996) in locomotion being reported. A possible explanation is related to doses, with lower doses of nociceptin inducing increased locomotor activity while higher doses decreased exploratory locomotor behaviour.…”

Section: Discussionmentioning

confidence: 99%

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Redrobe

Calò

Guerrini

et al. 2000

British J Pharmacology

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1 The present study was undertaken to investigate the e ects of the novel nociceptin receptor antagonist, [Nphe 1 ]-Nociceptin (1-13)-NH 2 (bilateral intrahippocampal injection, 50 nmole rat 71 ) on purported nociceptin-induced (bilateral intrahippocampal injection, 5 nmole rat 71 ) de®cits in spatial learning in the rat Morris water maze task. In addition, experiments were performed in an`open ®eld' to investigate possible peptide-induced changes in exploratory behaviour. 2 Nociceptin signi®cantly impaired the ability of the animal to locate the hidden platform throughout training (P50.001 versus control group). 3 Pretreatment with [Nphe 1 ]-Nociceptin (1-13)-NH 2 signi®cantly blocked nociceptin-induced impairment of spatial learning (P50.001 versus nociceptin group). 4 A probe trial revealed that vehicle-treated animals spent more time in the quadrant that had previously contained the hidden platform, whereas nociceptin-treated animals did not spend more time in any one quadrant. 5 Learning impairments were not attributable to non-speci®c de®cits in motor performance or change in exploratory behaviour. 6 Taken together, our results reveal that [Nphe 1 ]-Nociceptin (1-13)-NH 2 represents an e ective and useful in vivo antagonist at the nociceptin receptors involved in learning and memory.

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Section: Discussionmentioning

confidence: 99%

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Redrobe

Calò

Guerrini

et al. 2000

British J Pharmacology

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“…Intracerebroventricular injections of N/OFQ cause various behavioural e ects in rodents, including stimulation of food intake (Pomonis et al, 1996), inhibition or stimulation of spontaneous locomotion (Reinscheid et al, 1995;Florin et al, 1996), antagonism of the reinforcing properties of ethanol or morphine (Ciccocioppo et al, 1999;Murphy et al, 1999) and impairment of spatial learning (Sandin et al, 1997), among other actions. The peptide also a ects nociceptive transmission/perception, inducing either hyperalgesia (Meunier et al, 1995;Reinscheid et al, 1995) or reversal of analgesia mediated or induced by opioids Grisel et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Central injections of nocistatin or its C‐terminal hexapeptide exert anxiogenic‐like effect on behaviour of mice in the plus‐maze test

Gavioli

Rae

Calò

et al. 2002

British J Pharmacology

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1 Nocistatin (NST) antagonizes several actions of nociceptin/orphanin FQ (N/OFQ), but acts on distinct receptors. As N/OFQ exerts anxiolytic-like actions in various tests, its behavioural actions in the elevated plus-maze (EPM) test were compared with those of bovine NST. 2 Five minutes after i.c.v. treatment, mice were placed on the EPM for 5 min and entries into and time spent on open and closed arms were recorded alongside other parameters. 3 NST (0.1 ± 3 pmol) reduced percentages of entries into (control 39.6+3.1%, peak e ect at 1 pmol NST 8.5+2.9%) and time spent on open arms (control 30.8+2.3%, NST 2.7+1.5%). The C-terminal hexapeptide of NST (NST-C6; 0.01 ± 10 pmol) closely mimicked these actions of NST, with peak e ects at 0.1 pmol. 4 N/OFQ (1 ± 100 pmol) increased percentages of entries into (control 38.5+3.4%; peak e ect at 10 pmol N/OFQ 67.9+4.9%) and time spent on open arms (control 32.0+3.8%; N/OFQ 74.9+5.8%). Closed arm entries, an index of locomotor activity, were unchanged by all peptides. 5 E ects of NST or NST-C6, but not N/OFQ, were still detectable 15 min after injection. Behaviour of animals co-injected with NST (1 pmol) or NST-C6 (0.1 pmol) plus N/OFQ (10 pmol) was indistinguishable from that of controls. 6 These results reveal potent anxiogenic-like actions of NST and NST-C6, and con®rm the anxiolytic-like properties of N/OFQ. As NST and N/OFQ both derive from preproN/OF, anxiety may be modulated in opposing directions depending on how this precursor is processed.

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“…In previous studies, i.c.v. injection of 0.01-0.5 nmol N/OFQ (Florin et al, 1996;Jenck et al, 1997;Kuzmin et al, 2004;Sakoori and Murphy, 2004) or systemic administration of intermediate doses of Ro 64-6198 (3-6 mg/Kg, Higgins et al, 2001) facilitated spontaneous locomotion in rodents. This facilitation was previously related to the wellknown anxiolytic effect of NOP receptor agonists (Jenck et al, 1997).…”

Section: N/ofq Modulates Behavior and Motor Cortex Output M Marti Et Almentioning

confidence: 99%

“…In particular, i.c.v. injections of N/OFQ or systemic administration of Ro 64-6198 (a synthetic NOP receptor agonist) facilitated spontaneous locomotion at low doses (Florin et al, 1996;Jenck et al, 1997;Higgins et al, 2001;Kuzmin et al, 2004) and inhibited it at higher ones (Reinscheid et al, 1995;Devine et al, 1996;Rizzi et al, 2001;Higgins et al, 2001;Kuzmin et al, 2004). NOP receptor agonists also inhibited exercise-induced locomotion (as in the rotarod test) although in a monophasic way (Jenck et al, 2000;Higgins et al, 2001;Marti et al, 2004a).…”

Section: Introductionmentioning

confidence: 99%

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Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata

Marti

Viaro

Guerrini

et al. 2008

Neuropsychopharmacol

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This study was set to investigate whether motor effects of nociceptin/orphanin FQ (N/OFQ) can be related to changes in primary motor cortex output. N/OFQ injected i.c.v. biphasically modulated motor performance, low doses being facilitating and higher ones inhibitory. These effects were counteracted by the N/OFQ receptor antagonist [Nphe 1 Arg 14 ,Lys 15 ]N/OFQ-NH 2 (UFP-101) confirming the specificity of N/OFQ action. However, UFP-101 alone facilitated motor performance, suggesting that endogenous N/OFQ inhibits motor function. N/OFQ and UFP-101 injected into the substantia nigra reticulata but not motor cortex replicated these effects, suggesting motor responses were mediated by subcortical circuits involving the basal ganglia. Intracortical microstimulation technique showed that i.c.v. N/OFQ also biphasically modulated motor cortex excitability and movement representation. Low N/OFQ doses caused a leftward shift of threshold distribution curve in the forelimb area without affecting the number of effective sites. Conversely, high N/OFQ doses increased unresponsive and reduced excitable (movement) sites in vibrissa but not forelimb area. However, increased threshold currents and rightward shift of threshold distribution curve were observed in both areas, suggesting an overall inhibitory effect on cortical motor output. UFP-101 alone evoked effects similar to low N/OFQ doses, suggesting tonic inhibitory control over forelimb movement by endogenous N/OFQ. As shown in behavioral experiments, these effects were replicated by intranigral, but not intracortical, N/OFQ or UFP-101 injections. We conclude that N/OFQ receptors located in the substantia nigra reticulata mediate N/OFQ biphasic control over motor behavior, possibly through changes of primary motor cortex output.

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Nociceptin stimulates locomotion and exploratory behaviour in mice

Cited by 132 publications

References 11 publications

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Central injections of nocistatin or its C‐terminal hexapeptide exert anxiogenic‐like effect on behaviour of mice in the plus‐maze test

Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata

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Nociceptin stimulates locomotion and exploratory behaviour in mice

Cited by 132 publications

References 11 publications

[Nphe1]‐Nociceptin (1‐13)‐NH2, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe1]‐Nociceptin (1‐13)‐NH2, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

Central injections of nocistatin or its C‐terminal hexapeptide exert anxiogenic‐like effect on behaviour of mice in the plus‐maze test

Nociceptin/Orphanin FQ Modulates Motor Behavior and Primary Motor Cortex Output Through Receptors Located in Substantia Nigra Reticulata

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[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats

[Nphe¹]‐Nociceptin (1‐13)‐NH₂, a nociceptin receptor antagonist, reverses nociceptin‐induced spatial memory impairments in the Morris water maze task in rats