Nociception- and anxiety-like behavior in rats submitted to different periods of restraint stress

Gameiro, Gustavo Hauber; Gameiro, Paula Hauber; Andrade, Annicele da Silva; Pereira, Lígia Ferrinho; Arthuri, Mariana Trevisani; Marcondes, Fernanda Klein; Veiga, Maria Cecı́lia Ferraz de Arruda

doi:10.1016/j.physbeh.2005.12.007

Cited by 145 publications

(103 citation statements)

References 49 publications

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“…Although the unpredictable stress procedures have been suggested as appropriate animal models of anxiety disorders due to their behavioral effects, these behavioral effects have not been measured after the cessation of the stress procedure [14,58]. Previous research with chronic predictable or single stress exposure reported an increase in anxiety measures 1-3 weeks following the last stress exposure [4,7,19,30,32,54,55,59]. Therefore, to systematically investigate the delayed effects of chronic unpredictable stress (CUS), the current study exposed rats to 10 days of unpredictable stress and then assessed anxiety on several behavioral measures 1, 7 or 14 days following the last stress exposure.…”

Section: Introductionmentioning

confidence: 99%

The delayed effects of chronic unpredictable stress on anxiety measures

Matuszewich

Karney

Carter

et al. 2007

Physiology & Behavior

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Previous research has found that exposure to unpredictable stress can augment anxiety in humans and animals. The appearance of anxiety symptoms in humans frequently develop after stress exposure has terminated, but few rodent studies have systematically examined the delayed anxiogenic effects of unpredictable stress. Therefore, the current study investigated whether anxiety-like behaviors in rats would increase at several time intervals following exposure to chronic unpredictable stress (CUS). Unconditioned and conditioned response tasks were used to assess anxiety in male rats 1, 7 or 14 days following exposure to 10 days of a variety of stressors. Rats exposed to CUS showed increased burying behaviors and immobility during the defensive burying test, a conditioned anxiety test. The effects on burying behavior were apparent 7 and 14 days after the termination of the unpredictable stress procedure, but not when tested 1 day after CUS. Total time immobile in the defensive burying test also increased 14 days after termination of the last stressor. In contrast, there were no significant effects of CUS on behavioral measures in the unconditioned response tasks, the elevated plus-maze or light-dark box, at any time point following exposure to CUS. The current findings suggest that CUS may be a useful model of human conditioned anxiety that develops subsequent to chronic stress exposure.

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Section: Introductionmentioning

confidence: 99%

The delayed effects of chronic unpredictable stress on anxiety measures

Matuszewich

Karney

Carter

et al. 2007

Physiology & Behavior

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“…Therefore, this is not a very satisfactory method of animal classifi cation, as it is based on a short lasting reaction and not on an enduring feature. The infl uence of trait anxiety on pain processing could be explained by: 1) possible differences on opioidergic and serotonergic activities between animals with high and low anxiety levels (Quintero et al, 2000;Torres et al, 2003;Gameiro et al, 2006); 2) possible differences in the levels of prostaglandins released during the infl ammatory response between animals with high and low anxiety levels (Morimoto et al, 1991); 3) possible glucocorticoid-resistence in animals with high anxiety levels (Miller et al, 2002); 4) possible differences on NK1 receptor expression between animals with high and low levels of anxiety (Ramos et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between anxiety and pain is a common experience in both preclinical (Quintero et al, 2000;Torres et al, 2001;Gameiro et al, 2006;Wilson et al, 2007) and clinical studies (Brown, 1990;Grachev et al, 2001;Dersh et al, 2002;McWilliams et al, 2003;Bonjardim et al, 2005). Preclinical investigations have confirmed the enhancing effect of anxiety on nociception for different components and measures, including nociception intensity (Al Absi and Rokke, 1991), nociception threshold (Rhudy and Meagher, 2000), and nociception discrimination (Schumacher and Velden, 1984).…”

Section: Introductionmentioning

confidence: 99%

“…So far, the general approach of preclinical studies to assess the relationship between anxiety and nociception has been to expose an animal to a stressor and examine the impact of this stressor on a nociception measure, or to evaluate alterations in anxiety processing following exposure to nociceptive stimuli (Takahashi and Kaneto 1999;Quintero et al, 2000;Torres et al, 2001;Gameiro et al, 2006;Boccalon et al, 2006). To the best of our knowledge, until now, only two studies have been aimed at evaluating the infl uence of baseline levels of anxiety (high and low) on pain processing (Ramos et al, 2002;Wilson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Trait anxiety affects the orofacial nociceptive response in rats

et al. 2011

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The aims of the present study were to assess the infl uence of: a) trait anxiety on orofacial pain; and b) orofacial pain on state anxiety. Fortyfour rats were initially exposed to the free-exploratory paradigm for the evaluation of their anxiety profi les. In accordance to the parameter "Percentage of time in the novel side", the animals were considered as presenting high or low levels of trait anxiety when presenting values below the 1st quartile, or above the 3rd quartile, respectively. A week later, formalin-1.5% was injected into the upper lip of each animal. The behavioural nociceptive response, characterized by increased orofacial rubbing (OR), was quantifi ed for 30 minutes, as follows: Total time OR (0-30 minutes: total pain), 1st phase OR (0-6 minutes: neurogenic pain), and 2nd phase OR (12-30 minutes: infl ammatory pain). Immediately after this test, but still under the effect of formalin, the rats were submitted to the Elevated Plus-maze test (EPM). The results showed that the high trait anxiety individuals presented higher frequency of OR than the low trait anxiety ones, except during the neurogenic pain period. However, no correlation was found between OR frequency and levels of state anxiety presented on the EPM. In conclusion, the animals presenting higher anxiety profi les were the most susceptible to orofacial pain, nevertheless, orofacial pain did not infl uence state anxiety.

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“…29 for review) or stress-induced hyperalgesia (SIH) (see ref. 30 for review), and although some evidence suggests that genetics, stress severity, context and chronicity may be relevant to the direction in which pain is modulated [31][32][33][34][35] , this topic remains greatly understudied. Also unappreciated is the fact that stress associated with pain testing can be surprisingly high (and hugely variable) in human participants as well.…”

Section: Jeffrey S Mogilmentioning

confidence: 99%

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

Mogil

2017

Lab Anim

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Nociception- and anxiety-like behavior in rats submitted to different periods of restraint stress

Cited by 145 publications

References 49 publications

The delayed effects of chronic unpredictable stress on anxiety measures

The delayed effects of chronic unpredictable stress on anxiety measures

Trait anxiety affects the orofacial nociceptive response in rats

Laboratory environmental factors and pain behavior: the relevance of unknown unknowns to reproducibility and translation

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