Nociceptive Nerve Fibers in the Sacroiliac Joint in Humans

Abstract

We conclude that the presence of CGRP and substance P immunoreactive fibers in the normal anterior capsular ligament and interosseous ligament provides a morphological and physiological base for pain signals originating from these ligaments. Therefore, diagnostic infiltration techniques for sacroiliac joint pain should consider extra- as well as intra-articular approaches.

Possible nociceptive structures in the sacroiliac joint cartilage: An immunohistochemical study

“…Searching for an explanation of SI joint pain, we performed an immunohistochemical study in human cadavers in which we found substance P and CGRP positive nerve fibers in the SI joint anterior capsular ligament and interosseous ligament (Szadek et al, 2008). In this study, we also found immunoreactive structures in sacral cartilage of a single specimen.…”

“…Although we did not find sensory nerves in subchondral bone in the present study, we observed occasional positive fibers in the bone marrow, but this does not explain pain originating from the SI joint. We did not use a neural specific stain against nonphosphorylated neurofilament antibodies in the present study because it does not reveal thin nerve fibers (Szadek et al, 2008).…”

Cadaveric Study of Sacroiliac Joint Innervation

“…1 The joint capsule, surrounding ligaments, and the intra-articular portion of the joint have been reported to be potential pain generators. [2][3][4][5][6] Sacroiliac joint pain has been treated with radiofrequency ablation (RFA) of the lateral branches of the posterior rami innervating the SIJ complex. A variety of RFA needle types/lesioning techniques/lesioning locations have been used, including single-conventional and cooled probe and multipolar strip lesions.…”

Síndrome de disfunción de la articulación sacroiliaca. Análisis clínico de los resultados a corto y mediano plazo de una serie de 115 pacientes tratados con bloqueo selectivo percutáneo

“…La articulación sacroiliaca puede ser la causa del dolor en un 15 %-30 % de los pacientes con patología lumbosacrococcígea y es la causante de dolor glúteo en el 50 % de los pacientes deportistas [6,[8][9][10][11]28,29,[51][52][53][54][55][56][57][58][59][60][61][62][63][64] [ 19,35,28,72,77,78,79,80,81,82]. Durante el parto, la articulación sacroiliaca, por contener una gran cantidad de ligamentos, logra arcos de movimiento mínimos; pero suficientes para permitir el aumento del diámetro de la cintura pélvica [1,5,47,72,74,83,84].…”