Nocturia is Associated with Poor Sleep Quality Among Older Women in the Study of Osteoporotic Fractures

Abstract

Objectives 1) To examine relationships between frequency of nocturia and self-reported sleep quality and objective sleep measures in older women and 2) to estimate the amount of variation in sleep measures that is specifically attributable to frequency of nocturia. Design and Setting Secondary, cross sectional analysis of the multicenter prospective cohort Study of Osteoporotic Fractures (SOF) Participants Community-dwelling women aged ≥ 80 years Measurements Frequency of nocturia in the previous 12 months, Pittsburgh Sleep Quality Index sleep quality subscale, and actigraphy-measured wake after sleep onset (WASO) and total sleep time (TST). Results Of 1,520 participants, 25% (N=392) reported their nocturia frequency was 3–4 times/night and an additional 60% (N=917) reported their nocturia frequency was 1–2 times/night. More frequent nocturia was associated with poor sleep quality (3–4/night: 26.8% reported fairly bad or very bad sleep quality; 1–2/night: 14.7%; 0/night: 7.7%; p<.001) and longer WASO (3–4/night: 89.8 minutes; 1–2/night: 70.6; 0/night: 55.5; p<.001). In nested regression models, a nocturia frequency of 3–4/night quadrupled the odds of poor sleep quality (odds ratio: 4.26 [95% CI 1.65, 11.01]; p=.003) and was associated with a 37-minute worsening in WASO (95% CI 26.0, 49.0; p<.001). Frequency of nocturia explained an additional 6% variation in WASO, above and beyond demographic, medical/psychiatric conditions, and medication factors (ΔR2=.06). Conclusions Nocturia is common among octogenarian and nonagenarian women and is independently associated with poor sleep quality and longer wake time at night. Interventions that improve nocturia may be useful in improving sleep quality and wake time at night.

A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study

“…These data were consistent with those from the CFS assessment. Poor sleep quality is widely reported in patients with CFS (31), and nocturia has been associated with poor sleep quality (32,33). In our study, we observed a significantly (P < 0.01) improved frequency of nocturia in the subjects of the product group (data not shown).…”

A botanical product containing cistanche and ginkgo extracts improves chronic fatigue syndrome: a randomized, double-blind, placebo-controlled study

“…These data were consistent with those from the CFS assessment. Poor sleep quality was widely reported in patients with CFS [16], and nocturia was associated with poor sleep quality [17,18]. In our study, we observed a signi cantly (P < 0.01) improved frequency of nocturia in the subjects of the product group (data not shown).…”

Association of multimorbidity with higher levels of urinary incontinence: a cross-sectional study of 23 089 individuals aged ≥15 years residing in Spain

“…First, changes in age-related immune functions, hormonal changes, and increasing incidence of comorbid diseases may facilitate urinary tract infections that can result in UI. 33 Second, poor sleep quality 34 is associated with nocturia (waking from sleep to void). Third, multimorbidity is associated with mild cognitive impairment 35 , 36 and with cognitive decline 37 and, in turn, those with a dementia diagnosis (a condition not available to the present study) have approximately three times the rate of diagnosis of UI.…”