Nocturnal and morning asthma. Relationship to plasma corticosteroids and response to cortisol infusion.

Soutar, C. A.; Costello, J; Ijaduola, O.; Turner-Warwick, M

doi:10.1136/thx.30.4.436

Cited by 126 publications

(30 citation statements)

References 11 publications

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“…Asthma, now recognized as an inflammatory disease (15), is characterized by nocturnal exacerbations (16). It has been suggested that this phenomenon is related at least in part to the fall in cortisol levels seen at night (17,18), although efforts to demonstrate this conclusively have not been successful (19). Circadian variation in rhinitis and immediate cutaneous responses to antigen, 48/80, and histamine have also been described, but none have been linked directly to changes in endogenous cortisol (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Herrscher

Kasper²,

Sullivan³

1992

J. Clin. Invest.

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To investigate the impact that physiological variation in serum cortisol has on IgE-mediated events, 10 atopic subjects underwent cutaneous antigen challenge with measurement of the early phase wheal (EPW) at 20 min and the late phase reaction (LPR) at 6 h. All subjects were challenged during control conditions between 8:00 and 9:00 a.m. Repeat challenges were performed in five subjects at 6:00 p.m. and in eight subjects after ingestion of metyrapone, a specific inhibitor of cortisol synthesis. Compared with control values, mean serum cortisol was suppressed in the evening and after metyrapone (P < 0.05 all time points). No effect was seen on the EPW, but mean LPR diameters at three antigen dilutions were significantly increased by cortisol suppression (P < 0.05). Replacement doses of hydrocortisone given in the evening and with metyrapone abrogated these increases. Blinded analysis of LPR biopsies from cortisol-suppressed subjects revealed increases in leukocytoclasis (P < 0.0001), interstitial leukocytes (P . 0.01), and eosinophils (P s 0.04). These results indicate that physiological levels of serum cortisol can regulate IgE-dependent cutaneous inflammation by affecting the expression of cellular events at late phase sites. (J. Clin. Invest. 1992. 90:596-603.)

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Section: Introductionmentioning

confidence: 99%

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Herrscher

Kasper²,

Sullivan³

1992

J. Clin. Invest.

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“…It has been suggested that the rhythm in plasma cortisol may be the pulmonary clock, since nadir of the cortisol rhythm occurs a few hours before that of PEFR rhythm which would be compatible with the delayed effects of corticosteroids on the airways. (11) In the study done by M. Goyal et al (12) 42 healthy, nonsmoking male adults of age group between 18-26 years among university population from north India. The PEFR (L/min.)…”

Section: Review Of Literaturementioning

confidence: 99%

Comparative Study of Circadian Rhythm of Peak Expiratory Flow Rate in South Indian Healthy Females and Asthmatic Females

Koganti¹,

Thangaswamy²,

Anisha³

et al. 2016

jemds

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AIM AND OBJECTIVESCross-sectional study to compare the peak expiratory flow rate with the help of "Mini-Wright" peak flow meter among females, normal healthy subjects and subjects who are asthmatics of age group 20-40 years. METHOD60 adult females of age group 20-40 years (30-Healthy and 30-Asthmatics) for whom baseline pulmonary function testing was done to differentiate normal and asthmatic. All cases were clinically examined to rule-out any obvious cardiopulmonary diseases. Subjects were provided one mini Wright's peak expiratory flow meter, were individually trained for measuring their own PEFR in L/min and were instructed to record the readings with Wright's portable peak

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“…Many other factors are associated with the nocturnal exacerbation of asthma (Figure 3). The robust circadian rhythms of cortisol dip during the night and the vagal tone increase during sleep are believed to contribute significantly to the diurnal variation in airway inflammation and reactivity (65,66). Cortisol binding and steroid responsiveness appear impaired in nocturnal asthma, resulting in impaired endogenous antiinflammatory processes (67).…”

Section: Obstructive Lung Disease Circadian Rhythm In Asthmamentioning

confidence: 99%

Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer

et al. 2016

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Physiological and cellular functions operate in a 24-hour cyclical pattern orchestrated by an endogenous process known as the circadian rhythm. Circadian rhythms represent intrinsic oscillations of biological functions that allow for adaptation to cyclic environmental changes. Key clock genes that affect the persistence and periodicity of circadian rhythms include BMAL1/CLOCK, Period 1, Period 2, and Cryptochrome. Remarkable progress has been made in our understanding of circadian rhythms and their role in common medical conditions. A critical review of the literature supports the association between circadian misalignment and adverse health consequences in sepsis, obstructive lung disease, obstructive sleep apnea, and malignancy. Circadian misalignment plays an important role in these disease processes and can affect disease severity, treatment response, and survivorship. Normal inflammatory response to acute infections, airway resistance, upper airway collapsibility, and mitosis regulation follows a robust circadian pattern. Disruption of normal circadian rhythm at the molecular level affects severity of inflammation in sepsis, contributes to inflammatory responses in obstructive lung diseases, affects apnea length in obstructive sleep apnea, and increases risk for cancer. Chronotherapy is an underused practice of delivering therapy at optimal times to maximize efficacy and minimize toxicity. This approach has been shown to be advantageous in asthma and cancer management. In asthma, appropriate timing of medication administration improves treatment effectiveness. Properly timed chemotherapy may reduce treatment toxicities and maximize efficacy. Future research should focus on circadian rhythm disorders, role of circadian rhythm in other diseases, and modalities to restore and prevent circadian disruption.

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Nocturnal and morning asthma. Relationship to plasma corticosteroids and response to cortisol infusion.

Cited by 126 publications

References 11 publications

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Endogenous cortisol regulates immunoglobulin E-dependent late phase reactions.

Comparative Study of Circadian Rhythm of Peak Expiratory Flow Rate in South Indian Healthy Females and Asthmatic Females

Timing Matters: Circadian Rhythm in Sepsis, Obstructive Lung Disease, Obstructive Sleep Apnea, and Cancer

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