Nocturnal Blood Pressure and Silent Cerebrovascular Lesions in Elderly Japanese

Watanabe, Noriko; Imai, Yutaka; Nagai, Kenichi; Tsuji, Ichiro; Satoh, Hiroshi; Sakuma, Masayoshi; Sakuma, Hiromichi; Kato, Jun; Onodera-Kikuchi, Noriko; Yamada, Masaaki; Abe, Fumiaki; Hisamichi, Shigeru; Abe, Keishi

doi:10.1161/01.str.27.8.1319

Cited by 109 publications

(71 citation statements)

References 50 publications

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“…Таким образом, при вечернем приеме препарата су-точный ритм становится более «выраженным», умень-шается «случайная», не связанная с суточным ритмом вариабельность АД. Вечернее назначение антигипертензивных препа-ратов вызывает некоторые опасения ввиду того, что значительное снижение ночного АД у больных с сер-дечно-сосудистыми заболеваниями может оказать негативное влияние на перфузию головного мозга и миокарда [17,18]. Однако веским аргументом в пользу безопасности ночного назначения рамиприла является снижение риска развития инсульта на 32%, продемонстрированное в исследовании HOPE, причем именно у пациентов, принимавших препарат в вечер-нее время [6].…”

Section: Discussionunclassified

Effect of Morning and Evening Ramipril Taking on Ambulatory Blood Pressure Profile in Patients With Arterial Hypertension

Горбунов

Fedorova

Деев

et al. 2009

Racionalʹnaâ farmakoterapiâ v kardiologii

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Section: Discussionunclassified

Effect of Morning and Evening Ramipril Taking on Ambulatory Blood Pressure Profile in Patients With Arterial Hypertension

Горбунов

Fedorova

Деев

et al. 2009

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…According to a recent meta-analysis of 17 randomised controlled trials, blood pressure (BP) lowering by 13/6 mm Hg for 4.9 years resulted in a 38% reduction of the risk of stroke and a 16% reduction of the risk of myocardial infarction (MI). 1 Larger circadian variation of BP 2,3 and excessive BP fall during night time 4,5 were associated with higher risk of cardiovascular events. A steep BP Correspondence: H Muratani, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan.…”

Section: Introductionmentioning

confidence: 99%

Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

et al. 2002

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Larger variability of office blood pressure (BP) was reportedly associated with a higher risk of stroke or mortality from all causes. In the present study, we focused on the relationship of variability of office BP and occurrence of acute myocardial infarction (MI). We registered 139 patients receiving antihypertensive therapy for more than 1 year who experienced first-ever episode of MI at the age of 60 years or over. At least two sex-and age-matched (؎5 years) control patients were registered for every MI patient. Average systolic and diastolic BP during the 12-month period prior to the occurrence of MI, or the time of registration in the case of control patients, was similar in both patient groups. The office BP variability was evaluated by calculating

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“…An excessive reduction in nocturnal BP induced by antihypertensive drugs can potentially lead to ischaemic cerebrovascular and cardiovascular complications at night. 30,31 This minimal effect of barnidipine on the nocturnal BP may therefore be beneficial, especially in patients with high cardiovascular risks.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Tolerability of Barnidipine Hydrochloride in Thai Patients with Hypertension

et al. 2004

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This open-label, blinded study was performed to evaluate the efficacy and tolerability of barnidipine at a titrated dose of 10 -15 mg once daily for 8 weeks in the treatment of essential hypertension in 40 Thai patients. 'Office' blood pressure (BP) and 24-h ambulatory BP measurements were recorded. A systolic BP/ diastolic BP (SBP/DBP) reduction of 18.0 ± 13.6/9.1 ± 6.6 mmHg was obtained. The full response rate among patients with systolic and diastolic hypertension was 63% using either SBP or DBP criteria, and 54% using both SBP and DBP criteria. One of the two patients with isolated systolic hypertension had a full response, and the BP in two of the three patients with isolated diastolic hypertension was normalized. The trough-to-peak ratio and smoothness index for SBP/DBP were acceptable (0.76 ± 0.63/0.55 ± 0.26 and 1.2 ± 0.4/1.2 ± 0.3, respectively). In conclusion, once-daily barnidipine monotherapy provides effective 24-h BP control and is generally well tolerated in ambulatory patients.

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Nocturnal Blood Pressure and Silent Cerebrovascular Lesions in Elderly Japanese

Cited by 109 publications

References 50 publications

Effect of Morning and Evening Ramipril Taking on Ambulatory Blood Pressure Profile in Patients With Arterial Hypertension

Effect of Morning and Evening Ramipril Taking on Ambulatory Blood Pressure Profile in Patients With Arterial Hypertension

Office blood pressure variability as a predictor of acute myocardial infarction in elderly patients receiving antihypertensive therapy

The Efficacy and Tolerability of Barnidipine Hydrochloride in Thai Patients with Hypertension

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